IP Library Granted Patent US 12,312,620
Granted Patent B2
US 12,312,620 · App. 18/070,903 · Granted May 27, 2025

Method of precipitating phytase

Inventors: Katja Palmunen (Rajamäki, FI); Mirkka Perkkalainen (Rajamäki, FI); Leena Lehtikari (Rajamäki, FI); Imke Kühn (Darmstadt, DE)
Assignee: AB Enzymes Oy
C12N9/96C12N9/16C12Y301/03008C12Y301/03026
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,312,620
App. No.
18/070,903
Granted
May 27, 2025
Kind
B2
Abstract

Herein is disclosed a process for effectively precipitating phytase as a complex with a polyanion, as well as compositions comprising phytase and a polyanion, and a method for manufacturing such compositions.

Claims (14)

1. A method of preparing a phytase composition comprising

i) providing an aqueous medium comprising phytase;

ii) preparing a reversible phytase-polyanion complex in an enzymatically active form by adding a polyanion selected from an alginic acid, a pectic acid, a hyaluronic acid, a salt thereof, or any combination thereof, to the aqueous medium; and

iii) directly recovering the reversible phytase-polyanion complex in an enzymatically active form to obtain the phytase composition;

wherein no Ca 2+ is added to the aqueous medium during the method.

2. The method of claim 1 , wherein the phytase composition is dehydrated to obtain a dry product.

3. The method of claim 1 , further comprising dissolving of the phytase composition to obtain a liquid product.

4. The method of claim 3 , further comprising dehydrating the phytase composition to obtain a dry product.

5. The method of claim 4 , further comprising dissolving the dry product to obtain a reconstituted product.

6. The method of claim 1 , further comprising washing the phytase composition.

7. The method of claim 6 , wherein the phytase composition is dehydrated to obtain a dry product.

8. The method of claim 6 , further comprising dissolving of the phytase composition to obtain a liquid product.

9. The method of claim 8 , further comprising dehydrating the phytase composition to obtain a dry product.

10. The method of claim 9 , further comprising dissolving the dry product to obtain a reconstituted product.

Assignments (2)
MERGER Recorded Aug 18, 2025
From: AB ENZYMES OY
To: ROAL OY
Reel/Frame 072042/0183 →
CHANGE OF NAME Recorded Aug 18, 2025
From: ROAL OY
To: AB ENZYMES FINLAND OY
Reel/Frame 072042/0201 →
Priority Claims (1)
EP 18205062 · Nov 8, 2018 · regional
Continuity (2)
Division 17288676
Related Publication 20230159909A1 · May 25, 2023
References Cited (14)
US 20110189344A1 · Bodo · 2011 [cited by examiner]
US 20210395719A1 · Palmunen et al. · 2021 [cited by applicant]
CN 104125778A · 2014 [cited by applicant]
CN 107455477A · 2017 [cited by applicant]
EP 0969089A1 · 2000 [cited by applicant]
WO 2013119468A2 · 2013 [cited by applicant]
Griffiths et al. Protein extraction and 2-DE of water- and lipid-soluble proteins from bovine pericardium, a low-cellularity tissue. Nov. 2008, Electrophoresis.(22):4508-15. (Year: 2008). [cited by examiner]
Tye et al., Molecular cloning and the biochemical characterization of two novel phytases from B. subtilis 168 and B. licheniformis, 2002, Appl Microbiol Biotechnol 59:190-197. (Year: 2002). [cited by examiner]
Demir et al., Phytase from Weissella halotolerans: purification, partialcharacterisation and the effect of some metals, 2017, International Journal of Food Properties, vol. 20, No. S2, S2127-S2137 (Year: 2017). [cited by examiner]
Celem, E. B., “Purification of alpha-Galactosidase by Affivity Precipitation with Alginate”, Prep Biochem. & Biotech., 38:4, 2008, 348-357. [cited by applicant]
Jain, S. et al., “Applications of Alginate in Bioseparation of Proteins”, Artificial Cells, Blood Substitutes, and Biotechnology, 34:2, 2006, 127-144. [cited by applicant]
Mufwez, O. D. et al., “Preparation new immobilized phytase from [cited by applicant]
Pandey, A. et al., “Production, purification and properties of microbial phytases”, Bioresource Technology, 77, 2001, 203-214. [cited by applicant]
Teotia, S. et al., “One-step purification of glucoamylase by affinity precipitation with alginate”, J. Mol. Recognit., 14, 2001, 295-299. [cited by applicant]