Contact lenses with microchannels
A contact lens comprising one or more microchannels for transport of liquid through the lens is provided. The contact lens can be made by contacting a curable composition with a microfiber that is insoluble in the curable composition; curing the curable composition to provide a polymeric lens body with the microfiber embedded therein; and contacting the polymeric lens body with a solvent to dissolve the microfiber.
1. A contact lens comprising:
a) a bulk polymer material defined by a front surface, a back surface, and a circumferential edge; and
b) at least one microchannel embedded within the bulk polymer material having a first opening located within 1.5 mm of the circumferential edge, and a second opening on the front surface or the back surface and located more than 2 mm away from the circumferential edge, wherein
when worn, the at least one microchannel transports liquid from a lower tear meniscus of an eye through the contact lens bulk to a location on the front surface or the back surface of the contact lens that is not in contact with the lower tear meniscus.
2. The contact lens of claim 1 , wherein the first opening is located within 1.0 mm of the circumferential edge.
3. The contact lens of claim 1 , wherein the first opening is located at or within 0.5 mm of the circumferential edge.
4. The contact lens of claim 1 , wherein the second opening is on the front surface.
5. The contact lens of claim 1 , wherein the second opening is on the back surface.
6. The contact lens of claim 1 , wherein the at least one microchannel is cylindrical in shape and has an average diameter of from 500 nm to 50 μm or is rectangular in shape with a height of from 5 μm to 50 μm and a width of from 5 μm to 5 mm.
7. The contact lens of claim 1 , wherein the at least one microchannel is a branched microchannel comprising a main microchannel and a plurality of branches fluidly connected to the main microchannel.
8. The contact lens of claim 7 , wherein the main microchannel has the first opening, one of the plurality branches has the second opening, and a remainder of the plurality of branches has a respective other opening.
9. The contact lens of claim 7 , wherein the plurality of branches each comprise a respective diameter smaller than a diameter of the main microchannel.
10. The contact lens of claim 7 , wherein the branched microchannel follows Murray's Law: r 0 3 =r 1 3 +r 2 3 + . . . +r n 3 , where r 0 is the radius of the main microchannel, and r 1 , . . . , r n are the radii of the plurality of branches depending from the main microchannel.
11. The contact lens of claim 1 , wherein the bulk polymer material comprises a silicone hydrogel.
12. The contact lens of claim 1 , wherein the bulk polymer material comprises a silicone elastomer.
13. The contact lens of claim 1 , wherein the at least one microchannel comprises a plurality of microchannels.
14. The contact lens of claim 1 , wherein the at least one microchannel does not intersect with any other microchannel.
15. The contact lens of claim 1 , wherein the at least one microchannel is not present within an optic zone of the contact lens.
16. The contact lens of claim 1 , further comprising at least one reservoir fluidly connected to the at least one microchannel, wherein the at least one reservoir has a length of 10 μm to 50 mm, a width of 10 μm to 5 mm, and a height of 10 μm to 150 μm.
17. The contact lens of claim 16 , wherein the at least one reservoir is fluidly connected to a second microchannel embedded within the bulk polymer material.
18. The contact lens of claim 16 , wherein the at least one reservoir comprises an array of reservoirs, wherein each of the array of reservoirs is fluidly connected to at least one of the at least one microchannel and another microchannel.
19. The contact lens of claim 16 , wherein the reservoir contains a liquid comprising hydroxyethyl cellulose, polyvinylpyrrolidone, polyvinyl alcohol, hyaluronic acid, or any combination thereof.
20. The contact lens of claim 16 , wherein the reservoir contains hyaluronic acid and a polymer selected from hydroxyethyl cellulose, polyvinylpyrrolidone, and polyvinyl alcohol.