CONTINUOUS PROCESS TO MAKE TRIFLUOROACETYL IODIDE FROM TRIFLUOROACETYL CHLORIDE AND HYDROGEN IODIDE BY REACTIVE DISTILLATION
The present disclosure provides a process for producing trifluoroacetyl iodide (TFAI) from trifluoroacetyl chloride (TFAC) and hydrogen iodide (HI) via reactive distillation. The process may be conducted in the presence or absence of a catalyst. The process may be conducted in the presence or absence of a solvent.
1 . A process for making trifluoroacetyl iodide (TFAI), the process comprising:
combining a stream comprising trifluoroacetyl chloride (TFAC) with a stream comprising hydrogen iodide (HI) to provide a combined reactant stream;
passing the combined reactant stream to a reactive distillation column to provide a crude product stream; and
purifying the crude product stream to provide a purified product stream comprising trifluoroacetyl iodide (TFAI).
2 . The process of claim 1 , wherein the molar ratio of TFAC:HI is about 1:1 to about 2:1.
3 . The process of claim 1 , wherein the reactive distillation column is a packed column further comprising a reboiler.
4 . The process of claim 1 , wherein the reactive distillation column reboiler temperature is about 50° C. to 110° C.
5 . The process of claim 1 , wherein the reactive distillation column is operated at a pressure of about 50 to 100 psig.
6 . The process of claim 1 , wherein purifying the crude product stream comprises passing the crude product stream to one or more distillation columns.
7 . The process of claim 1 , wherein the reactive distillation column further comprises a catalyst.
8 . The process of claim 7 , wherein the catalyst is selected from the group consisting of activated carbon, meso carbon, stainless steel, nickel, nickel-chromium alloy, nickel-chromium-molybdenum alloy, nickel-copper alloy, copper, alumina, platinum, palladium, iron carbide, molybdenum carbide, nickel carbide, silicon carbide, and combinations thereof.
9 . The process of claim 1 , wherein the combined reactant stream further comprises a solvent.
10 . The process of claim 9 , wherein the solvent is selected from the group consisting of benzene, toluene, xylenes, mesitylene (1,3,5-trimethylbenzene), ethyl benzene, dimethylformamide (DMF), dimethyl sulfoxide (DMSO), ionic liquids, and combinations thereof.
11 . The process of claim 9 , further comprising recovering iodine (I 2 ) from the purified product stream.