Method for treating anxiety disorders, headache disorders, and eating disorders with psilocybin
The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.
1. A method of treating anorexia in a patient in need thereof, the method comprising orally administering a therapeutically effective amount of an oral dosage form, wherein the oral dosage form comprises:
crystalline psilocybin characterized by XRPD peaks at 11.5±0.1, 12.0±0.1, 14.5±0.1, 17.5±0.1 and 19.7±0.1° 2θ, wherein crystalline psilocybin has a chemical purity of greater than 97% as determined by HPLC analysis; and
a pharmaceutically acceptable excipient.
2. The method of claim 1 , wherein about 1 mg to about 40 mg of crystalline psilocybin is administered.
3. The method of claim 1 , wherein about 10 mg to about 30 mg of crystalline psilocybin is administered.
4. The method of claim 1 , wherein about 1 mg of crystalline psilocybin is administered.
5. The method of claim 1 , wherein about 5 mg of crystalline psilocybin is administered.
6. The method of claim 1 , wherein about 10 mg of crystalline psilocybin is administered.
7. The method of claim 1 , wherein about 25 mg of crystalline psilocybin is administered.
8. The method of claim 1 , wherein the oral dosage form is a capsule.
9. The method of claim 1 , wherein the oral dosage form is a tablet.
10. The method of claim 1 , wherein the crystalline psilocybin is further characterized by at least one peak selected from the group consisting of 20.4±0.1, 22.2±0.1, 24.3±0.1, and 25.7±0.1° 2θ.
11. The method of claim 1 , wherein the crystalline psilocybin has no single impurity of greater than 1% as determined by HPLC analysis.
12. The method of claim 1 , wherein the patient is less than 18 years of age.
13. A method of treating anorexia, the method comprising administering a therapeutically effective amount of psilocybin to a patient in need thereof,
wherein the psilocybin comprises crystalline psilocybin characterized by X-ray powder diffraction (XRPD) peaks at 11.5±0.1, 12.0±0.1, 14.5±0.1, 17.5±0.1 and 19.7±0.1° 2θ, and wherein the crystalline psilocybin has a chemical purity of greater than 97% as determined by HPLC analysis.
14. The method of claim 13 , wherein about 1 mg to about 40 mg of psilocybin is administered.
15. The method of claim 13 , wherein about 10 mg to about 30 mg of psilocybin is administered.
16. The method of claim 13 , wherein about 1 mg of psilocybin is administered.
17. The method of claim 13 , wherein about 5 mg of psilocybin is administered.
18. The method of claim 13 , wherein about 10 mg of psilocybin is administered.
19. The method of claim 13 , wherein about 25 mg of psilocybin is administered.
20. The method of claim 13 , wherein the psilocybin is orally administered.
21. The method of claim 13 , wherein the psilocybin is administered in a capsule.
22. The method of claim 13 , wherein the psilocybin is administered in a tablet.
23. The method of claim 13 , wherein the crystalline psilocybin is further characterized by at least one peak selected from the group consisting of 20.4±0.1, 22.2±0.1, 24.3±0.1, and 25.7±0.1° 2θ.
24. The method of claim 13 , wherein the crystalline psilocybin has no single impurity of greater than 1% as determined by HPLC analysis.
25. The method of claim 13 , wherein the patient is less than 18 years of age.
26. The method of claim 1 , wherein the patient is at least 18 years of age.
27. The method of claim 13 , wherein the patient is at least 18 years of age.
28. The method of claim 1 , wherein the patient is 18 to 40 years of age.
29. The method of claim 13 , wherein the patient is 18 to 40 years of age.