PACKAGED COMPOSITIONS COMPRISING HYPOCHLOROUS ACID AND MENTHOL AND METHODS OF MAKING THEREOF
The present disclosure relates to packaged eyelid scrubs as well as methods for making the packaged eyelid scrubs. The packaged eyelid scrubs include a pharmaceutical composition that includes hypochlorous acid and menthol, and a package that includes an opaque airless spray container filled with the pharmaceutical composition. Methods of cleansing an eyelid using the pharmaceutical compositions are also described herein.
1 . A packaged eyelid or eyelash scrub composition, the packaged composition comprising:
a pharmaceutical composition comprising hypochlorous acid and menthol; and
a package comprising an opaque airless spray container filled with the pharmaceutical composition,
such that the pharmaceutical composition is stable for greater than 30 days after the airless spray container is actuated for the first time.
2 . The packaged composition of claim 1 , wherein the pharmaceutical composition has a viscosity from about 1 cP to about 10 cP.
3 . The packaged eyelid scrub composition of claim 1 , wherein the menthol is L-menthol.
4 . The packaged eyelid scrub composition of claim 3 , wherein the L-menthol has a concentration in the pharmaceutical composition from about 0.01% (w/w) to about 0.03% (w/w).
5 . The packaged eyelid scrub composition of claim 1 , wherein the hypochlorous acid has a concentration in the pharmaceutical composition from about 0.01% (w/w) to about 0.05% (w/w).
6 . The packaged eyelid scrub composition of claim 1 , wherein the pharmaceutical composition further comprises at least one surfactant.
7 . The packaged eyelid scrub composition of claim 7 , wherein the at least one surfactant is a non-ionic surfactant, an anionic surfactant, or combinations thereof.
8 . The packaged eyelid scrub composition of claim 8 , wherein the anionic surfactant is sodium lauryl sarcosinate.
9 . The packaged eyelid scrub composition of claim 8 , wherein the non-ionic surfactant is sorbitan monolaurate.
10 . The packaged eyelid scrub composition of claim 7 , wherein the at least one surfactant forms micelles.
11 . The packaged eyelid scrub composition of claim 7 , wherein the at least one surfactant has a concentration in the pharmaceutical composition of between about 0.1% (w/w) to about 2% (w/w).
12 . The packaged eyelid scrub composition of claim 1 , wherein the pharmaceutical composition further comprises a pH modifier.
13 . The packaged eyelid scrub composition of claim 12 , wherein the pH modifier is selected from the group consisting of hydrochloric acid and sodium hydroxide.
14 . The packaged eyelid scrub composition of claim 1 , wherein the pharmaceutical composition has a pH from about 4 and about 7.
15 . The packaged eyelid scrub composition of claim 1 , wherein the opaque airless container comprises glass, polyethylene terephthalate, low density polyethylene, polypropylene, or combinations thereof.
16 . The packaged eyelid scrub composition of claim 1 , wherein the opaque airless container meets USP acceptance criteria for light-resistant packaging components.
17 . The packaged eyelid scrub composition of claim 1 , wherein the percentage of spectral transmission of the opaque airless spray container the opaque airless spray container at any wavelength of light between 290 nm and 450 nm is 25% or less.
18 . The packaged eyelid scrub composition of claim 17 , wherein the percentage of spectral transmission of the opaque airless spray container at any wavelength of light between 290 nm and 450 nm is 10% or less.
19 . The packaged eyelid scrub composition of claim 1 , wherein the hypochlorous acid has a concentration in the pharmaceutical composition of at least about 200 ppm for at least 30 days after the opaque airless spray container is actuated for the first time.
20 . The packaged eyelid scrub composition of claim 1 , wherein the pharmaceutical composition further comprises an active ingredient.