Devices and methods for delivery of electrical current for pain relief
Device/system that provides pain relief by delivering stimulation that neither generates action potentials nor completely blocks neural transmission (in the peripheral nerve). The present teachings provide relief by modulating release of neurotransmitters in peripheral nerves to cause neuromodulation at the level of the peripheral nerve (modulation of neural signals in the peripheral nerve). The present teachings provide relief by modulating release of neurotransmitters in peripheral nerves to cause neuromodulation at the level of the peripheral nerve (modulation of neural signals in the peripheral nerve) to alter the frequency of physiologically generated neural transmission.
1. A method of treating pain comprising:
deploying an electrode outside of a central nervous system;
delivering electric current having stimulation parameters via an electrical stimulator through the electrode to peripheral nerve tissue and without directly stimulating an action potential in the peripheral nerve tissue, wherein the stimulation parameters alter transmission and production of action potentials in the peripheral nerve tissue, wherein one of the stimulation parameters comprises an intensity of 1-2 mA;
changing probability of action potentials occurring as a result of the stimulation parameters utilized in the delivery of the electric current;
changing excitability of at least one nerve as a result of the stimulation parameters utilized in the electric current; and
changing conduction velocity, shape, or interpulse interval of action potentials as a result of the stimulation parameters utilized in the electric current and wherein the electrical current does not block or interrupt efferent signals and motor nerve signals.
2. The method of claim 1 , wherein the electrical current does not cause paresthesias.
3. The method of claim 1 wherein the electrical current alters action potentials in neural targets via activation, inactivation, excitation, or suppression of non-neural tissue.
4. The method of claim 3 wherein the non-neural tissue is a glial cell.
5. The method of claim 1 wherein the electrical current is delivered through the electrode located 1.0 mm or more away from the peripheral nerve tissue.
6. The method of claim 1 , wherein the electric current causes changes to a frequency of action potentials.
7. The method of claim 1 , wherein the electric current causes changes to form, features, period, rate, coefficient of variation, or duration of action potentials.
8. The method of claim 7 , wherein the electric current causes changes to timing, spacing, or pattern of action potentials or trains of action potentials.
9. The method of claim 1 , wherein the electric current causes changes to a frequency of action potentials and changes to form, features, period, rate, coefficient of variation, or duration of action potentials.
10. A method of treating pain comprising:
deploying an electrode outside of a central nervous system;
applying electrical stimulation having stimulation parameters in peripheral nerve tissue via the electrode and an electrical stimulation device, wherein the electrical stimulation parameters of the electrical stimulation:
alters transmission of action potentials in the peripheral nerve tissue;
changes a probability of action potentials occurring;
changes excitability of at least one nerve of said peripheral nerve tissue; and
changes conduction velocity, shape, or interpulse interval of action potentials, wherein the electrical current does not block or interrupt efferent signals and motor nerve signals, wherein one of the electrical stimulation parameters comprises an intensity of 1-2 mA.
11. The method of claim 10 , wherein the electrical stimulation does not cause paresthesias.
12. The method of claim 10 wherein the electrical stimulation alters action potentials in neural targets via activation, inactivation, excitation, or suppression of non-neural tissue.
13. The method of claim 10 wherein the electrical stimulation is delivered through the electrode located 1.0 mm or more away from the peripheral nerve tissue.
14. A method of treating pain comprising:
deploying an electrode into tissue outside of a central nervous system;
delivering electric current having stimulation parameters to a peripheral nerve tissue via an electrical stimulator and the electrode, wherein one of the stimulation parameters comprises an intensity of 1-2 mA;
altering transmission and production of action potentials in the peripheral nerve tissue without directly stimulating an action potential in the peripheral nerve tissue via the electric current and the stimulation parameters;
changing probability of action potentials occurring via the delivery of the electric current;
changing excitability of at least one nerve via delivery of the electric current; and
changing conduction velocity, shape, interpulse interval of action potentials via delivery of the electric current and wherein the electrical current does not block or interrupt efferent signals and motor nerve signals.
15. The method of claim 14 , wherein the electrical current does not cause paresthesias.
16. The method of claim 14 wherein the electrical current alters action potentials in neural targets via activation, inactivation, excitation, or suppression of non-neural tissue.
17. The method of claim 14 , wherein the electrical current is delivered through the electrode located 1.0 mm or more away from the peripheral nerve tissue.
18. The method of claim 14 , wherein the electric current causes changes to a frequency of action potentials.
19. The method of claim 14 , wherein the electric current causes changes to form, features, period, rate, coefficient of variation, or duration of action potentials.
20. The method of claim 19 , wherein the electric current causes changes to timing, spacing, or pattern of action potentials or trains of action potentials.