Hybrid optical parametrically-oscillating emitter
An optical-resolution photoacoustic microscopy (OR-PAM) system for visualizing water content deep in biological tissue uses an all-fiber 1930-nm hybrid optical parametrically-oscillating emitter. The emitter includes a tunable laser source whose output is amplified by a first erbium-doped fiber amplifier (EDFA). The output of the first amplifier is modulated with a Mach-Zehnder amplitude modulator that receives an RF signal with a nanosecond pulse width and a multiple kilohertz repetition rate. A second EDFA further amplifies the signal and passes it to a fiber circulator that in turn delivers it to a 1950/1550 mm fiber wavelength-division-multiplexing coupler WDM. The coupler introduces the signal to a cavity that includes a spool of highly nonlinear fiber and a Thulium-doped fiber amplifier TDFA. From the TDFA the signal reaches a 50/50 fiber coupler that sends part to a second output TDFA and guides part back to the cavity through a port of the WDM.
1 . An optical-resolution photoacoustic microscopy (OR-PAM) system for visualizing water content in the deep tissue of biological organisms, comprising as an input an all-fiber hybrid optical parametrically-oscillating emitter operating in a range from 1877 nm to 1980 nm, wherein the hybrid structure uses nonlinear fibers with stable phase matching and rare-earth fibers.
2 . The system of claim 1 wherein the all-fiber hybrid optical parametrically-oscillating emitter comprises:
a tunable laser source (TLD) generating a laser beam;
a first erbium-doped fiber amplifier (EDFA1) that receives the laser beam and amplifies it;
a Mach-Zehnder amplitude modulator (AM) that receives the amplified laser beam and generates a rectangular pulse train therefrom, said modulator being driven by a radio frequency signal with a certain nanosecond pulse width and a particular kilohertz repetition rate, wherein tuning a polarization state of the laser with a polarization controller causes a four-wave mixing process that converts the pump energy to a narrowband idler at a wavelength from 1800 nm to 2000 nm with the pump wavelength tuned from 1541 nm to 1563 nm;
a second erbium-doped fiber amplifier (EDFA2) that receives the rectangular pulse train and boosts the average power thereof;
a fiber circulator (CIR1) that receives the boosted pulse train and passes it to a nm fiber wavelength-division-multiplexing coupler (WDM);
a cavity that receives the boosted pulse train from the coupler, said cavity including a spool of multiple meters of highly nonlinear fiber with stable phase-matching so as to improve nonlinear efficiency (HNLF-SPINE, OFS), which acts as the parametric gain medium in the cavity, and a 1-m Thulium-doped fiber that amplifies (first TDFA) the idler and in which the residual pump in the 1550-nm band is further depleted for boosting the idler power to enhance the cavity ga
in;
a 50/50 fiber coupler connected to the first TDFA so that one stream of the laser signal is output from the cavity and another stream containing the idler is guided back to the input of the cavity through a multiple meter spool of single-mode fiber (SMF) to increase the cavity length, the idler being input to the cavity via an port of the WDM; and
a second TDFA 2 that receives the output for the cavity and provides an extra power pumping at 1650 nm and the output of the emitter.
3 . The system of claim 2 further including a tunable bandpass filter with a 1-nm spectral bandwidth located between the modulator and the second EDFA2 so as to filter out undesired amplified spontaneous emission (ASE).
4 . The system of claim 2 wherein the radio frequency pulse width is 15 ns and the repetition rate is 50 kHz, the cavity spool of HNLF-SPINE is about 50 meters and the spool of SMF is about 200 meters, the first EDFA1 amplifies the laser beam to about 10 mW and the second EDFA2 boosts the average power to 2-W with a peak of 2.67 kW.
5 . The system of claim 1 wherein the OR-PAM) system further comprises:
a collimator for receiving the output light beam of the emitter and expanding it;
an objective lens for receiving the expanded light beam and focusing it;
a sample in a water tank upon which the focused light is directed to excite photoacoustic signals;
an ultrasonic transducer collects photoacoustic waves from the sample at the same location where the focused light beam engages it and converts it to electrical signals;
an RF amplifier for increasing the magnitude of the electrical signals;
a digital converter that converts the electrical signals into digital signals and displaying them so as to show the water content in the deep tissue of biological organisms.
6 . The system of claim 5 further including an X-Y-Z translational stage holding the sample water tank so as to be able to move the sample in the focused beam and conduct raster-scanning of the sample.
7 . The system of claim 5 wherein the focused beam is directed to the sample through an optical window.
8 . The system of claim 5 wherein the RF amplifier is two cascaded RF low-noise amplifiers.
9 . The system of claim 5 further including a low-pass filter between the an RF amplifier and the digital converter.
10 . The system of claim 5 wherein the digital converter is an oscilloscope.
11 . The system of claim 10 wherein the PA signal has its center frequency at 10 MHz, the sampling rate of the oscilloscope is set to 100 MHz and the sampling length is selected to be 500 for a 5-μs time window.
12 . The system of claim 5 wherein the digital converter is a data acquisition card and a personal computer.
13 . An all-fiber hybrid optical parametrically-oscillating emitter comprising:
a tunable laser source (TLD) generating a laser beam;
a first erbium-doped fiber amplifier (EDFA1) that receives the laser beam and amplifies it;
a Mach-Zehnder amplitude modulator (AM) that receives the amplified laser beam and generates a rectangular pulse train therefrom, said modulator being driven by a radio frequency signal with a certain nanosecond pulse width and a particular kilohertz repetition rate, wherein tuning a polarization state of the laser with a polarization controller causes a four-wave mixing process that converts the pump energy to a narrowband idler at a wavelength from 1800 nm to 2000 nm with the pump wavelength tuned from 1541 nm to 1563 nm;
a second erbium-doped fiber amplifier (EDFA2) that receives the rectangular pulse train and boosts the average power thereof to about 2 W with a peak of about 2.67 kW;
a fiber circulator (CIR1) receives the boosted pulse train and passes it to a fiber wavelength-division-multiplexing coupler (WDM);
a cavity that receives the boosted pulse train from the coupler, wherein the cavity includes a spool of multiple meters of highly nonlinear fiber with stable phase-matching so as to improve nonlinear efficiency (HNLF-SPINE, OFS), which acts as the parametric gain medium in the cavity, and a 1-m Thulium-doped fiber that amplifies (first TDFA) the idler and in which the residual pump in the 1550-nm band is further depleted for boosting the idler power to enhance the cavity gain;
a 50/50 fiber coupler connected to the first TDFA so that one stream of the laser signal is output from the cavity and another stream containing the idler is guided back to the input of the cavity through a spool of further multiple meters of single-mode fiber (SMF) to increase the cavity length, the idler being input to the cavity via an input port of WDM; and
a second TDFA 2 that receives the output from the cavity and provides an extra power pumping at 1650 nm as the output of the emitter.
14 . The all-fiber hybrid optical parametrically-oscillating emitter of claim 13 wherein the radio frequency pulse width is 15 ns and the repetition rate is 50 kHz, the cavity spool of HNLF-SPINE is about 50 meters and the spool of SMF is about 200 meters, the first EDFA1 amplifies the laser beam to about 10 mW and the second EDFA2 boosts the average power to 2-W with a peak of 2.67 kW.
15 . The all-fiber hybrid optical parametrically-oscillating emitter of claim 13 further including a tunable bandpass filter with a 1-nm spectral bandwidth located between the modulator and the second EDFA2 so as to filter out undesired amplified spontaneous emission (ASE).
16 . The all-fiber hybrid optical parametrically-oscillating emitter of claim 13 operating in a range from 1900 nm to 2000 nm.
17 . The all-fiber hybrid optical parametrically-oscillating emitter according to claim 16 wherein fiber wavelength-division-multiplexing coupler (WDM) is a 1950/1550 multiplexing coupler and the input to cavity is a 1950 nm input and the emitter operates at 1930 nm.