IP Library Granted Patent US 12,168,121
Granted Patent B2
US 12,168,121 · App. 18/084,394 · Granted Dec 17, 2024

Devices and methods for treating or preventing development disorders

Inventors: Bruce J. Simon (Santa Fe, NM); Joseph P. Errico (Palm Beach Gardens, FL); John T. Raffle (Austin, TX)
Assignee: ELECTROCORE, INC.
A61N1/0456A61N1/0408A61N1/36025A61N1/36034A61N1/40A61N2/006A61N2/02
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Quick Facts
Patent No.
US 12,168,121
App. No.
18/084,394
Granted
Dec 17, 2024
Kind
B2
Abstract

Devices, systems and methods are disclosed for treating or preventing a developmental disorder, such as attention-deficit hyperactivity disorder (ADHD), an autism spectrum disorder, Asperger syndrome, childhood disintegrative disorder, overactive disorder, pervasive developmental disorder. A device comprises an electrode having a contact surface for contacting an outer skin surface of a patient and a power source coupled the electrode. The power source generates and transmits an electrical impulse having a frequency of about 1 kHz to about 20 kHz through the contact surface and the outer skin surface to a nerve within the patient. The electrical impulse is sufficient to modify the behavioral disorder in the patient.

Claims (14)

1. A method for treating a developmental condition or disorder, comprising:

positioning an electrode in contact with an outer skin surface of a pregnant woman to treat the developmental condition or disorder in a fetus within the pregnant woman;

generating an electrical impulse with an energy source

transmitting the electrical impulse through the electrode and the outer skin surface to a nerve within the pregnant woman, wherein the electrical impulse is sufficient to modify the developmental condition or disorder in the fetus, wherein the electrical impulse comprises a frequency of about 1 kHz to about 20 kHz.

2. The method of claim 1 , wherein the frequency is about 2.5 kHz to about 7.5 kHz.

3. The method of claim 1 , further comprising a housing, wherein the electrode is housed within, or on, the housing.

4. The method of claim 3 , wherein the power source is housed within the housing, wherein the power source comprises a signal generator coupled to the electrode within the housing.

5. The method of claim 1 , wherein the electrical impulse comprises bursts of about 2 to about 20 pulses with a silent intra-burst interval between each burst and wherein each pulses have a frequency of about 1 kHz to about 20 kHz.

6. The method of claim 5 , wherein each burst has a frequency of about 1 to about 100 bursts per second and each pulse is about 50 to 1000 microseconds in duration.

7. The method of claim 1 , wherein the nerve is a vagus nerve.

8. The method of claim 1 , further comprising positioning the electrode in contact with an outer skin surface of a neck of the pregnant woman.

9. The method of claim 1 , wherein the developmental condition or disorder comprises attention-deficit hyperactivity disorder (ADHD), an autism spectrum disorder, Asperger syndrome, childhood disintegrative disorder, overactive disorder, or a pervasive developmental disorder.

10. The method of claim 1 , further comprising applying the electrical impulse according to a treatment regimen that comprises transmitting the electrical impulse for a time period of less than 30 minutes several times a week.

11. The method of claim 1 , further comprising applying the electrical impulse during a first trimester of the pregnant woman's pregnancy.

Assignments (2)
SECURITY INTEREST Recorded Aug 12, 2025
From: ELECTROCORE, INC.
To: AVENUE VENTURE OPPORTUNITIES FUND II, L.P.
Reel/Frame 072452/0559 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 19, 2022
From: ELECTROCORE, LLC
To: ELECTROCORE, INC
Reel/Frame 062147/0934 →
Continuity (17)
Continuation 16662140 · Oct 24, 2019
Division 13783319 · Mar 3, 2013
Continuation In Part 13731035 · Dec 30, 2012
Continuation In Part 13603781 · Sep 5, 2012
Continuation In Part 13222087 · Aug 31, 2011
Continuation In Part 13183765 · Jul 15, 2011
Continuation In Part 13183721 · Jul 15, 2011
Continuation In Part 13109250 · May 17, 2011
Continuation In Part 13075746 · Mar 30, 2011
Continuation In Part 13005005 · Jan 12, 2011
Continuation In Part 12964050 · Dec 9, 2010
Provisional Application 61488208 · May 20, 2011
Provisional Application 61487439 · May 18, 2011
Provisional Application 61471405 · Apr 4, 2011
Provisional Application 61451259 · Mar 10, 2011
Provisional Application 61415469 · Nov 19, 2010
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