DRUG VEHICLE COMPOSITIONS AND METHODS OF USE THEREOF
The invention is directed to topical drug vehicle platform compositions for ophthalmological and dermatological use. These compositions are capable of solubilizing active ingredients having a logP value of more than about 3.0 and/or having a solubility in deionized water of about 33,000 parts per million or less at 25° C.
1 . A drug vehicle composition comprising:
an active ingredient wherein the active ingredient has a logP value of about 3.0 or more; and
one or more nonionic surfactants at a total concentration from about 1.5% to about 5.9% w/v,
wherein w/v denotes weight by total volume of the composition.
2 . The composition of claim 1 , wherein the active ingredient has a logP value of about 3.5 or more.
3 . The composition of claim 1 , wherein the active ingredient has a logP value of about 4.0 or more.
4 . The composition of claim 1 , wherein the active ingredient is selected from the group consisting of cyclosporine, tacrolimus, ketoprofen, naproxen, ibuprofen and flurbiprofen.
5 . The composition of claim 1 , wherein the one or more nonionic surfactants are selected from the group consisting of polyoxyls, polyoxyl castor oils, polyoxyl stearates, poloxamers polyoxyethyleneglycol alkyl ethers, tyloxapols and cyclodextrins.
6 . The composition of claim 1 , wherein the one or more nonionic surfactants are:
from about 1.0% to about 5.0% w/v polysorbate 80;
from about 0.1% to about 2.0% w/v poloxamer 407;
from about 0.1% to about 5.0% w/v poloxamer 188; and
from about 0.001% to about 1.0% w/v polyoxyl castor oil.
7 . The composition of claim 1 , further comprising hydroxypropylmethyl cellulose, mannitol, magnesium chloride and sodium chloride.
8 . The composition of claim 7 , comprising:
from about 0.1% to about 2.0% w/v hydroxypropylmethyl cellulose;
from about 0.5% to about 4.0% w/v mannitol;
from about 0.01% to about 0.5% w/v magnesium chloride; and
from about 0.1% to about 0.9% w/v sodium chloride.
9 . The drug vehicle composition of claim 8 , wherein:
polysorbate 80 is at a concentration from about 1.0% to about 2.0% w/v;
poloxamer 407 is at a concentration from about 0.1% to about 1.0%w/v;
poloxamer 188 is at a concentration from about 0.5% to about 1.5% w/v;
polyoxyl castor oil is at a concentration from about 0.005% to about 0.015% w/v;
hydroxypropylmethyl cellulose is at a concentration from about 0.85% to about 1.85% w/v;
mannitol is at a concentration from about 1.0% to about 2.0% w/v;
magnesium chloride is at a concentration from about 0.05% to about 0.5% w/v; and
sodium chloride is at a concentration from about 0.1% to about 0.5% w/v.
10 . A drug vehicle composition comprising:
an active ingredient wherein the active ingredient has a solubility in deionized water of about 33,000 parts per million or less at 25° C.; and
one or more nonionic surfactants at a total concentration from about 1.5% to about 5.9% w/v,
wherein w/v denotes weight by total volume of the composition.
11 . The drug vehicle of claim 10 , wherein the active ingredient has a solubility in deionized water of about 1,000 parts per million or less at 25° C.
12 . The drug vehicle of claim 10 , wherein the active ingredient has a solubility in deionized water of about 500 parts per million or less at 25° C.
13 . The drug vehicle of claim 10 , wherein the active ingredient has a solubility in deionized water of about 100 parts per million or less at 25° C.
14 . The composition of claim 10 , wherein the active ingredient is selected from the group consisting of cyclosporine, tacrolimus, ketoprofen, naproxen, ibuprofen, flurbiprofen, alcaftadine, azelastine hydrochloride, azithromycin, besifloxacin, betaxolol hydrochloride, bimatoprost, bepotastine besilate, brinzolamide, bromfenac, diclofenac, difluprednate, dorzolamide, emedastine difumarate, epinastine hydrochloride, erythromycin, fluorometholone acetate, gentamycin, gramicidin, ketorolac tromethamine, ketotifen fumarate, latanoprost, levobunolol hydrochloride, lodoxamide tromethamine, loteprednol etabonate, moxifloxacin, ofloxacin, olopatadine hydrochloride, polymyxin B, prednisolone acetate, rimexolone, tafluprost, timolol maleate, tobramycin, travoprost, trimethoprim, and combinations thereof.
15 . The composition of claim 10 , wherein the one or more nonionic surfactants are:
from about 1.0% to about 5.0% w/v polysorbate 80;
from about 0.1% to about 2.0% w/v poloxamer 407;
from about 0.1% to about 5.0% w/v poloxamer 188; and
from about 0.001% to about 1.0% w/v polyoxyl castor oil.
16 . The composition of claim 10 , further comprising hydroxypropylmethyl cellulose, mannitol, magnesium chloride and sodium chloride.
17 . The composition of claim 16 , comprising:
from about 0.1% to about 2.0% w/v hydroxypropylmethyl cellulose;
from about 0.5% to about 4.0% w/v mannitol;
from about 0.01% to about 0.5% w/v magnesium chloride; and
from about 0.1% to about 0.9% w/v sodium chloride.
18 . The drug vehicle composition of claim 17 , wherein:
polysorbate 80 is at a concentration from about 1.0% to about 2.0% w/v;
poloxamer 407 is at a concentration from about 0.1% to about 1.0%w/v;
poloxamer 188 is at a concentration from about 0.5% to about 1.5% w/v;
polyoxyl castor oil is at a concentration from about 0.005% to about 0.015% w/v;
hydroxypropylmethyl cellulose is at a concentration from about 0.85% to about 1.85% w/v mannitol is at a concentration from about 1.0% to about 2.0% w/v;
magnesium chloride is at a concentration from about 0.05% to about 0.5% w/v; and
sodium chloride is at a concentration from about 0.1% to about 0.5% w/v.
19 . A drug vehicle composition comprising:
from about 0.05% to about 0.09% w/v cyclosporine-A;
about 1.5% w/v polysorbate 80;
from about 0.5% to about 0.7% w/v poloxamer 407;
about 1.0% w/v poloxamer 188;
about 0.01% w/v polyoxyl castor oil;
about 1.35% w/v hydroxypropylmethyl cellulose;
from about 1.25% to about 1.75% w/v mannitol;
from about 0.05% to about 0.212% w/v magnesium chloride;
from about 0.25% to about 0.35% w/v sodium chloride;
about 0.1% w/v sorbate;
about 4 millimolar citrate buffer; and
water,
wherein the composition has a pH of about 7.0 and wherein w/v denotes weight by total volume of the composition.
20 . The drug vehicle composition of claim 19 comprising,
about 0.09% w/v cyclosporine-A;
about 0.7% w/v poloxamer 407;
about 1.75% w/v mannitol;
about 0.212% w/v magnesium chloride;
about 0.25% w/v sodium chloride; and
about 0.1% w/v potassium sorbate.
21 . The drug vehicle composition of claim 19 comprising,
about 0.5% w/v poloxamer 407;
about 1.25% w/v mannitol;
about 0.05% w/v magnesium chloride; and
about 0.35% w/v sodium chloride.
22 . The drug vehicle composition of claim 21 , wherein the cyclosporine-A is at a concentration of about 0.05% w/v.
23 . The drug vehicle composition of claim 21 , wherein the cyclosporine-A is at a concentration of about 0.075% w/v.
24 . The drug vehicle composition of claim 21 , wherein the cyclosporine-A is at a concentration of about 0.09% w/v.