Granted Patent
B2
US 12,415,074 · App. 18/107,498 · Granted Sep 16, 2025
Sensory threshold and/or adaptation for neurological therapy screening and/or parameter selection, and associated systems and methods
Assignee:
Nevro, Inc.
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Abstract
Systems and methods for using sensory threshold and/or adaptation for neurological therapy screening and/or parameter selection. A representative method for establishing a treatment regimen for a patient includes: in response to a first indication of a characteristic of the patient's sensory response to an electrical stimulus, providing a second indication indicating suitability of an electrical signal for delivery to the patient to address a patient condition, wherein the electrical signal has a frequency in a frequency range from 1.2 kHz to 100 kHz.
Claims (35)
1. A method of treating a patient, the method comprising:
determining a level of adaptation of a patient's sensory response to a suprathreshold electrical stimulus for each of a plurality of different electrodes and/or electrode combinations;
based on the determined levels of adaptation, selecting a specific electrode and/or electrode combination of the plurality of different electrodes and/or electrode combinations for delivery of an electrical signal to the patient to address a patient condition; and
programming a signal generator to generate and deliver the electrical signal to the patient via the selected specific electrode and/or electrode combination.
2. The method of claim 1 , further comprising delivering the electrical signal to the patient via the selected specific electrode and/or electrode combination to address the patient condition.
3. The method of claim 1 wherein the different electrodes and/or electrode combinations have different locations within the patient.
4. The method of claim 1 wherein determining the level of adaptation at each of the plurality of different electrodes and/or electrode combinations includes determining a level of adaptation for two or more different biopole pairs of electrodes.
5. The method of claim 1 wherein selecting the specific electrode and/or electrode combination based on the determined levels of adaptation includes:
comparing the levels of adaptation determined for each of the different electrodes and/or electrode combinations; and
selecting the specific electrode and/or electrode combination based on the comparison.
6. The method of claim 5 wherein selecting the specific electrode and/or electrode combination based on the comparison includes selecting the specific electrode and/or electrode combination associated with the largest level of adaptation.
7. The method of claim 1 wherein the electrical signal is a paresthesia-free electrical signal.
8. The method of claim 1 wherein the electrical signal has a frequency within a frequency range of from about 1.2 kHz to about 100 kHz.
9. A method of treating a patient, the method comprising:
receiving a first indication of a level of adaptation of a patient's sensory response to a suprathreshold electrical stimulus for each of a plurality of different electrodes and/or electrode combinations;
based on the first indication, providing a second indication identifying a specific electrode and/or electrode combination for delivery of an electrical signal to address a patient condition; and
based on the second indication, programming a signal generator to generate and deliver the electrical signal to the patient via the identified specific electrode and/or electrode combination.
10. The method of claim 9 , further comprising delivering the electrical signal to the patient via the identified electrode and/or electrode combination.
11. The method of claim 9 wherein the identified electrode and/or electrode combination includes a bipole electrode pair.
12. The method of claim 9 wherein providing the second indication based on the first indication includes analyzing the first indication to determine which electrode and/or electrode combination is associated with the largest level of adaptation to the suprathreshold electrical stimulus.
13. The method of claim 9 wherein the electrical signal does not induce paresthesia in the patient.
14. The method of claim 9 wherein the electrical signal has a frequency in a frequency range of from about 1.2 kHz to about 100 kHz.
15. The method of claim 9 wherein the patient condition includes pain.
16. The method of claim 9 wherein the different electrodes and/or electrode combinations are implanted at different locations within the patient.
17. A system for treating a patient, the system comprising:
a machine-readable medium having first instructions and second instructions,
wherein the first instructions, when executed:
receive a first indication of a level of adaptation of a patient's sensory response to a suprathreshold electrical stimulus for each of a plurality of different electrodes and/or electrode combinations, and
based on the first indication, provide a second indication identifying a specific electrode and/or electrode combination for delivery of an electrical signal to address a patient condition, and
wherein the second instructions, when executed, cause the electrical signal to be delivered to the patient via the identified specific electrode and/or electrode combination.
18. The system of claim 17 wherein the operation of providing the second indication based on the first indication includes:
comparing the levels of adaptation for each of the different electrodes and/or electrode combinations; and
identifying the specific electrode and/or electrode combination based on the comparison.
19. The system of claim 18 wherein identifying the specific electrode and/or electrode combination based on the comparison includes identifying the specific electrode and/or electrode combination associated with the largest level of adaptation.
20. The system of claim 17 wherein the electrical signal is a paresthesia-free electrical signal and has a frequency within a frequency range of from about 1.2 kHz to about 100 kHz.
Assignments (3)
RELEASE OF SECURITY INTEREST
Recorded Apr 4, 2025
From: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT
To: NEVRO CORP.
Reel/Frame 070743/0001 →
PATENT SECURITY AGREEMENT
Recorded Dec 1, 2023
From: NEVRO CORP.
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT
Reel/Frame 065744/0302 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Feb 24, 2023
From: LEE, DONGCHUL
To: NEVRO CORP.
Reel/Frame 062801/0930 →
Continuity (3)
Provisional Application
62793738
· Jan 17, 2019
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