MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
1 - 40 . (canceled)
41 . A process of preparing a compound:
comprising the steps of:
a) converting
into
b) converting
into
c) converting
into
d) converting
into
e) converting
into
f) converting
into
and
g) converting
into
42 . A process of preparing a compound:
comprising the steps of:
a) converting
into
b) converting
into
c) converting
into
d) converting
into
e) converting
into
f) converting
into
and
g) converting
into
43 . A process of preparing a compound:
comprising the steps of:
a) converting
into
b) converting
into
c) converting
into
and
d) converting
into
44 . A process of preparing a compound:
comprising the steps of:
a) converting
into
b) converting
into
c) converting
into
d) converting
into
e) converting
into
and
f) converting
into
45 . A process of preparing a compound:
comprising the steps of:
a) converting
into
b) converting
into
and
c) converting
into
46 . A process of preparing a compound:
comprising the steps of:
a) converting
into
b) converting
into
and
c) converting
into
47 . A compound having the following formula:
48 . A pharmaceutical composition comprising a compound of claim 47 and a pharmaceutically acceptable carrier.
49 . A method of treating cystic fibrosis comprising a compound of claim 47 .