Method of treating cancer
This invention is directed to the treatment of cancer, particularly castration-resistant prostate cancer and osteoblastic bone metastases, with a dual inhibitor of MET and VEGF.
1. A method for treating castration resistant prostate cancer (CRPC) or osteoblastic bone metastases associated with CRPC, comprising administering to a patient in need of such treatment a therapeutically effective amount of Compound 1:
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein Compound 1 is in the form of the malate salt.
3. The method of claim 2 , wherein Compound 1 is in the form of the (L)- or (D)-malate salt.
4. The method of claim 1 , for treating CRPC.
5. The method of claim 1 , for treating osteoblastic bone metastases associated with CRPC.
6. The method of claim 1 , wherein Compound 1, or a pharmaceutically acceptable salt thereof, is administered as a pharmaceutical composition additionally comprising a pharmaceutically acceptable carrier, excipient, or diluent.