Dry powder drug delivery system and methods
A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, with or without a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, hormones such as insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, diseases and disorders, including endocrine disease such as diabetes and/or obesity.
1. A dry powder inhalation system, comprising: a dry powder for oral inhalation and a dry powder inhaler, wherein the dry powder inhaler comprises: a) a first element comprising a mouthpiece; b) a second element comprising a cartridge, including, a powder container and a lid; and c) at least two rigid air conduits;
wherein one of the at least two rigid air conduits in a dosing configuration includes a deflector or stem protruding from an undersurface of the lid facing an internal volume of the powder container configured to direct airflow entering the internal volume of the powder container along a pathway that is substantially U-shaped from a direction parallel to the mouthpiece to a substantially downward direction to a direction substantially parallel to the mouthpiece through the dry powder to a direction substantially perpendicular to the mouthpiece to exit the powder container;
wherein in a containment configuration the dry powder is sealed from the at least two rigid air conduits and from the deflector or stem;
wherein the powder container comprising a first vertical wall and a second vertical wall parallel and opposed; and
wherein in the dosing configuration the deflector or stem is disposed between the first vertical wall and the second vertical wall.
2. The dry powder inhalation system of claim 1 , where the dry powder inhaler has a resistance value to airflow ranging from about 0.065 (√kPa)/liter per minute to about 0.200 (√kPa)/liter per minute.
3. The dry powder inhalation system of claim 1 , wherein the powder container is integrated into a container housing.
4. The dry powder inhalation system of claim 3 , wherein the powder container includes the dry powder.
5. The dry powder inhalation system of claim 1 , wherein the powder container is provided separate from the inhaler and is filled with a dry powder.
6. The dry powder inhalation system of claim 1 , wherein the dry powder is a pharmaceutical formulation and comprises an amount from about 1 mg to about 50 mg of the dry powder.
7. The dry powder inhalation system of claim 1 , wherein the dry powder comprises a drug or an active agent.
8. The dry powder inhalation system of claim 7 , wherein the active agent is an endocrine hormone, vaccines, small molecules, including anti-asthmatics, vasodilators, vasoconstrictors, muscle relaxants, or neurotransmitter agonist or antagonists.
9. The dry powder inhalation system of claim 1 , wherein the dry powder comprises a peptide, a polypeptide, or fragments thereof, a small organic molecule or a nucleic acid molecule.
10. The dry powder inhalation system of claim 9 , wherein said peptide is insulin, glucagon, glucagon-like peptide-1, parathyroid hormone, deoxyribonuclease, oxytocin, oxyntomodulin, peptide YY, an exendin, or fragments thereof.
11. The dry powder inhalation system of claim 9 , wherein the small organic molecule is a vasodialator, a vasoconstrictor, a neurotransmitter agonist or a neurotransmitter antagonist.
12. The dry powder inhalation system of claim 11 , wherein the small organic molecule is a triptan or an opiate.
13. The dry powder inhalation system of claim 12 , wherein the triptan is sumatriptan or rizatriptan.
14. The dry powder inhalation system of claim 1 , wherein the dry powder is an amorphous powder.
15. The dry powder inhalation system of claim 1 , wherein the dry powder comprises a diketopiperazine or a pharmaceutically acceptable salt thereof.
16. The dry powder inhalation system of claim 15 , wherein the diketopiperazine is of the formula 2,5-diketo-3,6-bis(N—X-4-aminobutyl) piperazine, wherein X is selected from the group consisting of fumaryl, succinyl, maleyl, malonyl, oxalyl and glutaryl.
17. The dry powder inhalation system of claim 16 , wherein the diketopiperazine is 3,6-bis-(N-fumaryl-4-aminobutyl)-2,5-diketopiperazine.
18. A dry powder inhalation system comprising: a dose of a dry powder medication and a high resistance dry powder inhaler, wherein the high resistance dry powder inhaler comprises: a) a first element comprising a mouthpiece; and b) at least two rigid air conduits; wherein one of the at least two rigid air conduits in a dosing configuration includes a deflector or stem protruding from an undersurface of a lid facing an internal volume of a powder container configured to direct airflow entering the internal volume of the powder container along a pathway that is substantially U-shaped from a direction parallel to the mouthpiece to a substantially downward direction to a direction substantially parallel to the mouthpiece through the dry powder to a direction substantially perpendicular to the mouthpiece to exit the powder container; and wherein in a containment configuration the dry powder is sealed from the at least two rigid air conduits and from the deflector or stem; wherein the powder container comprises a first vertical wall and a second vertical wall parallel and opposed; wherein in the dosing configuration the deflector or stem is disposed between the first vertical wall and the second vertical wall.
19. The dry powder inhalation system of claim 18 , wherein the dry powder comprises insulin, glucagon, glucagon-like peptide-1, parathyroid hormone, deoxyribonuclease, oxytocin, oxyntomodulin, peptide YY, an exendin, or fragments thereof.
20. A dry powder inhalation system, comprising:
a dry powder and a dry powder inhaler, wherein the dry powder inhaler comprises: a) a first element comprising a mouthpiece; b) a second element comprising a cartridge, including, a powder container and a lid; and c) at least two rigid air conduits;
wherein one of the at least two rigid air conduits in a dosing configuration includes a deflector or stem protruding from an undersurface of the lid configured to direct airflow entering the internal volume of the powder container along a pathway that is substantially U-shaped; and
wherein in a containment configuration the dry powder is sealed from the at least two rigid air conduits and from the deflector or stem.
21. The dry powder inhalation system of claim 20 , wherein the dry powder comprises insulin, glucagon, glucagon-like peptide-1, parathyroid hormone, deoxyribonuclease, oxytocin, oxyntomodulin, peptide YY, an exendin, or fragments thereof.