THROMBORESISTANT COATINGS, COATED DEVICES, AND METHODS
Embodiments herein relate to thromboresistant coatings, coated devices, and related methods. In an embodiment, a thromboresistant implantable, partially implantable, or wearable medical device is included having a substrate, a non-fouling basecoat layer, and a lubricious topcoat layer. The non-fouling basecoat layer can include a hydrophilic component and a hydrophobic component. The non-fouling basecoat layer is disposed over the substrate. The lubricious topcoat layer can include a photo-reactive polyvinylpyrrolidone compound and a cross-linking agent. The lubricious topcoat layer can be disposed over the non-fouling basecoat layer. Other embodiments are also included herein.
1 . A thromboresistant implantable, partially implantable, or wearable medical device comprising:
a substrate; and
a non-fouling basecoat layer, the non-fouling basecoat layer comprising
a hydrophilic component; and
a hydrophobic component;
wherein the non-fouling basecoat layer is disposed over the substrate;
a lubricious topcoat layer, the lubricious topcoat layer comprising
a photo-reactive polyvinylpyrrolidone compound; and
a cross-linking agent; and
wherein the lubricious topcoat layer is disposed over the non-fouling basecoat layer.
2 . (canceled)
3 . The medical device of claim 1 , the hydrophobic component comprising a poly(n-butyl methacrylate).
4 . The medical device of claim 1 , the hydrophilic component comprising a polyvinylpyrrolidone polymer.
5 . The medical device of claim 4 , the polyvinylpyrrolidone polymer comprising a cross-linked polyvinylpyrrolidone.
6 . The medical device of claim 4 , the hydrophilic component further comprising an acrylamide polymer, wherein the polyvinylpyrrolidone polymer and the acrylamide polymer are cross-linked.
7 . (canceled)
8 . The medical device of claim 1 , wherein a ratio of the hydrophobic component to the hydrophilic component in the non-fouling basecoat layer is from about 2.5:1 to 3.5:1 by weight.
9 . The medical device of claim 1 , the non-fouling basecoat layer further comprising a heparin compound.
10 . The medical device of claim 9 , the heparin compound comprising a photoreactive group.
11 - 16 . (canceled)
17 . The medical device of claim 1 , the lubricious topcoat layer further comprising a heparin compound.
18 . The medical device of claim 17 , the heparin compound comprising a photoreactive group.
19 . The medical device of claim 17 , wherein the heparin compound is cross-linked with the photo-reactive polyvinylpyrrolidone compound.
20 . The medical device of claim 17 , the heparin compound comprising an elutable heparin compound, wherein the elutable heparin compound is ionically complexed with a polycationic polymer.
21 . The medical device of claim 20 , the polycationic polymer comprising at least one selected from the group consisting of PEI, PHEMA-co-DMAEMA, and PEG-DMAEMA.
22 . The medical device of claim 1 , the lubricious topcoat layer further comprising a non-photoreactive polyvinylpyrrolidone.
23 - 27 . (canceled)
28 . The medical device of claim 8 , the lubricious topcoat layer further comprising a polyacrylamide polymer.
29 - 31 . (canceled)
32 . The medical device of claim 8 , the lubricious topcoat layer further comprising a polyzwitterion.
33 - 35 . (canceled)
36 . The medical device of claim 8 , the lubricious topcoat layer further comprising an anionic polymer.
37 . (canceled)
38 . The medical device of claim 1 , the lubricious topcoat layer further comprising:
a first layer; and
a second layer, wherein the second layer is disposed on the first layer and is different than the first layer.
39 . (canceled)
40 . The medical device of claim 1 , the lubricious topcoat layer further comprising an elutable antiplatelet macromer.
41 . (canceled)
42 . The medical device of claim 1 , the lubricious topcoat layer further comprising a non-prodrug anti-platelet agent.
43 - 81 . (canceled)