Granted Patent
B2
US 12,458,530 · App. 18/124,989 · Granted Nov 4, 2025
Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis
Inventors:
Jwala Karnik (Santa Barbara, CA); Jason Reynolds (Santa Rosa, CA); John Allison (Los Altos, CA); Clint Carnell (Park City, UT)
Assignee:
Pacira CryoTech, Inc.
A61F7/12A61B18/02A61B2018/00041A61B2018/00434A61B2018/00565A61B2018/0212A61B2018/0262A61B2018/0293A61B2018/1425A61F2007/0063A61F2007/0093A61F2007/0096A61F2007/0285
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Abstract
Embodiments include a cryogenic device for alleviating pain by cryogenically treating a nerve, the cryogenic device including a handpiece; a needle coupled to a distal end of the handpiece, the needle including a needle lumen, the needle being configured for insertion into a skin of a patient along an insertion axis at a site laterally displaced from a treatment zone proximate to the nerve. The needle is configured to resiliently bend after insertion away from the insertion axis, such that at least a portion of the needle is adapted to traverse a skin layer laterally toward the treatment zone. The device includes a cooling fluid supply tube extending distally into the needle lumen; and a cooling fluid source, wherein the cooling fluid source is coupled to the cooling fluid supply tube to direct cooling fluid into the needle lumen.
Claims (24)
1 . A system for reducing knee pain experienced by a patient, the system comprising:
a guide for identifying a treatment zone with reference to a skin surface of a patient, wherein the guide is configured to be placed on the skin surface of the patient relative to body landmarks; and
a treatment probe configured for directing a treatment under the skin surface with reference to the treatment zone identified by the guide, the treatment configured to modulate a nerve associated with pain of a knee of a leg.
2 . The system of claim 1 , wherein the treatment probe is configured to modulate the nerve with focused cold therapy.
3 . The system of claim 2 , wherein the guide identifies a zone for treating an infrapatellar branch of a saphenous nerve.
4 . The system of claim 3 , wherein the guide identifies a zone with a superior boundary defined by a midline of a patella of the leg.
5 . The system of claim 3 , wherein the guide identifies a zone with an inferior boundary defined by a tibial tubercle of the leg.
6 . The system of claim 3 , wherein the guide identifies a zone with a medial boundary defined by a distance lateral to a medial aspect of the patellar tendon of the leg.
7 . The system of claim 3 , wherein the guide identifies a zone with a lateral boundary defined by a distance lateral to a lower pole of a patella of the leg.
8 . The system of claim 2 , wherein the pain is associated with osteoarthritis of the knee, and wherein the nerve is an infrapatellar branch of a saphenous nerve, a lateral femoral cutaneous nerve, or an anterior femoral cutaneous nerve.
9 . The system of claim 1 , wherein the guide comprises a window that defines a treatment zone.
10 . The system of claim 1 , wherein the guide comprises an adhesive backing configured to adhere the guide to the skin surface of the patient.
11 . The system of claim 1 , wherein the guide comprises indicia configured to be aligned relative to a landmark of the body landmarks.
12 . The system of claim 1 , wherein the guide further comprises transdermal medication.
13 . The system of claim 1 , wherein the treatment probe is configured to modulate the nerve with thermal energy.
14 . The system of claim 13 , wherein radio frequency is used to create the thermal energy.
15 . A method for alleviating knee pain experience by a patient, the method comprising:
positioning a distal end of a cryogenic cooling needle having a needle lumen proximal a target tissue comprising a nerve associated with pain of a knee of a leg;
delivering a treatment cycle to the target tissue with the cryogenic cooling needle, the treatment cycle comprising a cooling phase where cooling fluid flows into the needle lumen so that liquid from the cooling flow vaporizes within the needle lumen to provide cooling to the nerve such that knee pain is mitigated or reduced.
16 . The method of claim 15 , further comprising placing a guide on a skin surface relative to body landmarks so as to identify a skin region overlying the target tissue.
17 . The method of claim 16 , wherein the guide identifies the skin region overlying an infrapatellar branch of a saphenous nerve of the patient, wherein the guide identifies the skin region with a superior boundary defined by a midline of a patella of the leg; an inferior boundary defined by a tibial tubercle of the leg; a medial boundary defined by a distance lateral to a medial aspect of the patellar tendon of the leg ranging between 40-48 mm; or a lateral boundary defined by a distance lateral to a lower pole of a patella of the leg ranging between 50-60 mm.
18 . The method of claim 15 , further comprising identifying the target tissue using a percutaneous electrical nerve stimulation device.
19 . The method of claim 15 , further comprising identifying the target tissue using ultrasound imaging.
20 . The method of claim 15 , wherein the pain is associated with osteoarthritis of the knee, and wherein the nerve is an infrapatellar branch of a saphenous nerve, a lateral femoral cutaneous nerve, or an anterior femoral cutaneous nerve.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 25, 2023
From: KARNIK, JWALA; REYNOLDS, JASON; ALLISON, JOHN; CARNELL, CLINT
To: MYOSCIENCE, INC.
Reel/Frame 063437/0300 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 25, 2023
From: MYOSCIENCE, INC.
To: PACIRA CRYOTECH, INC.
Reel/Frame 063444/0912 →
Continuity (7)
Provisional Application
61801268
· Mar 15, 2013
Provisional Application
61800478
· Mar 15, 2013
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