Granted Patent B2

US 12,318,573 · App. 18/128,559 · Granted Jun 3, 2025

Inventor: Shaun D. Gittard (Winston-Salem, NC)

Assignee: COOK MEDICAL TECHNOLOGIES LLC

A61M5/155A61M11/02A61M13/00A61M37/00A61M2205/8225Y10T428/2982

Abstract

Claims (39)

1. A system suitable for delivering a therapeutic agent to a target site, the system comprising:

a therapeutic agent, the therapeutic agent having one or more particles having a diameter and mass;

a container for holding the therapeutic agent;

pressurized fluid in selective fluid communication with at least a portion of the container;

a catheter in fluid communication with the container and having a lumen sized for delivery of the therapeutic agent to a target site,

wherein a diameter of the one or more particles of the therapeutic agent is in a range of between 45 micron to 925 microns, and

wherein the mass of the one or more particles of the therapeutic agent is in a range of between about 0.0001 mg to about 0.5 mg.

2. The system of claim 1 , further comprising a pressure source holding the pressurized fluid, the pressure source being in selective fluid communication with at least a portion of the container.

3. The system of claim 1 , wherein a regulated pressure of the pressurized fluid is between about 0.5 psi to about 75 psi.

4. The system of claim 1 , wherein the pressurized fluid is directed through a first region of the container in a direction towards a second region of the container, and wherein the fluid is at least partially redirected to urge the therapeutic agent in a direction from the second region of the container towards the first region of the container and subsequently towards the target site.

5. The system of claim 4 , wherein, during use, the first region of the container is disposed vertically above the second region of the container.

6. The system of claim 1 , wherein the therapeutic agent comprises a powder.

7. The system of claim 1 , wherein the pressurized fluid comprises carbon dioxide.

8. The system of claim 1 , wherein a ratio of an inner diameter of the catheter to the diameter of the one or more particles when delivered is at least 4:1 and less than or equal to 51:1.

9. The system of claim 8 , wherein the ratio of the inner diameter of the catheter to the diameter of the one or more particles when delivered is at least 4:1 and less than or equal to 18:1.

10. A system suitable for delivering a therapeutic agent to a target site, the system comprising:

a therapeutic agent, the therapeutic agent having one or more particles having a diameter and mass;

a container for holding the therapeutic agent;

pressurized fluid in selective fluid communication with at least a portion of the container;

a catheter in fluid communication with the container and having a lumen sized for delivery of the therapeutic agent to a target site,

wherein a diameter of the one or more particles of the therapeutic agent is in a range of between about 1 micron to about 925 microns,

wherein the mass of the one or more particles of the therapeutic agent is in a range of between about 0.0001 mg to about 0.5 mg, and

wherein the one or more particles of the therapeutic agent are sieved to produce a desired diameter in the range of between about 1 micron to about 925.

11. The system of claim 10 , further comprising a pressure source holding the pressurized fluid, the pressure source being in selective fluid communication with at least a portion of the container.

12. The system of claim 10 , wherein a regulated pressure of the pressurized fluid is between about 0.5 psi to about 75 psi.

13. The system of claim 10 , wherein the pressurized fluid is directed through a first region of the container in a direction towards a second region of the container, and wherein the fluid is at least partially redirected to urge the therapeutic agent in a direction from the second region of the container towards the first region of the container and subsequently towards the target site.

14. The system of claim 13 , wherein, during use, the first region of the container is disposed vertically above the second region of the container.

15. The system of claim 10 , wherein the therapeutic agent comprises a powder.

16. A system suitable for delivering a therapeutic agent to a target site, the system comprising:

a therapeutic agent, the therapeutic agent having one or more particles having a diameter and mass;

a container for holding the therapeutic agent;

pressurized fluid in selective fluid communication with at least a portion of the container;

a catheter in fluid communication with the container and having a lumen sized for delivery of the therapeutic agent to a target site,

wherein the diameter of the one or more particles of the therapeutic agent is in a range of between about 1 micron to about 925 microns,

wherein a ratio of an inner diameter of the catheter to the diameter of the one or more particles when delivered is at least 4:1 and less than or equal to 18:1.

17. The system of claim 16 , wherein the mass of the one or more particles of the therapeutic agent is in a range of between about 0.0001 mg to about 0.5 mg.

18. The system of claim 16 , wherein a regulated pressure of the pressurized fluid is between about 0.01 psi to about 100 psi.

19. The system of claim 16 , wherein the pressurized fluid is directed through a first region of the container in a direction towards a second region of the container, and wherein the fluid is at least partially redirected to urge the therapeutic agent in a direction from the second region of the container towards the first region of the container and subsequently towards the target site.

20. The system of claim 19 , wherein, during use, the first region of the container is disposed vertically above the second region of the container.

Assignments (1)

Continuity (4)

References Cited (400)