ANTIMICROBIAL COMPOSITION
The present invention provides an antimicrobial composition comprising at least one garlic extract and one or more of a bioflavonoid and/or an organic acid as well as the use of the same for treating or preventing bacterial, fungal or parasitic infections.
1 - 31 . (canceled)
32 . A method of inhibiting growth of Staphylococcus aureus , the method comprising contacting Staphylococcus aureus bacteria with a composition comprising a garlic extract and at least one bioflavonoid, wherein the garlic extract is at least one of ajoene or allicin, and the at least one bioflavonoid is at least one of: galangin, kaempferol, luteolin, myricetin, quercetin or sillibinin.
33 . The method according to claim 32 , wherein a concentration ratio of the garlic extract to the at least one bioflavonoid is about 1-4:4-1.
34 . The method according to claim 33 , wherein the composition includes the garlic extract at a level of 1.5625-25 μg/ml.
35 . The method according to claim 33 , wherein a concentration of the at least one bioflavonoid is inverse a concentration of the garlic extract within the concentration ratio.
36 . The method according to claim 35 , wherein the composition includes the garlic extract at a level of 1.5625-25 μg/ml.
37 . The method according to claim 36 , wherein the composition includes the at least one bioflavonoid at a level of 1.5625-25 μg/ml.
38 . The method according to claim 32 , wherein the composition further comprises an organic acid.
39 . The method according to claim 38 , wherein a concentration ratio of the garlic extract to the organic acid is about 1-16:16-1.
40 . The method according to claim 38 , wherein a concentration ratio of the garlic extract to the organic acid is about 1-4:4-1.
41 . The method according to claim 38 , wherein a concentration ratio of the garlic extract to the at least one bioflavonoid and to the organic acid is about 1-4:1-4:1-4.
42 . The method according to claim 38 , wherein a concentration ratio of the garlic extract to the at least one bioflavonoid and to the organic acid is about 1:4:2.
43 . The method according to claim 38 , wherein the organic acid comprises malic acid or citric acid.
44 . The method according to claim 32 , wherein the composition further comprises a pharmaceutically acceptable carrier and/or excipient.
45 . The method according to claim 32 , wherein the allicin is produced by an enzymatic reaction of alliin.
46 . The method according to claim 32 , wherein the composition provides a synergistic effect and has more inhibiting activity than an additive activity of each of the garlic extract and the at least one bioflavonoid alone at a same level.
47 . The method according to claim 32 , further comprising administering the composition to a subject in need thereof.
48 . The method according to claim 47 , further comprising administering the composition as or in a food for the subject.
49 . The method according to claim 47 , further comprising administering the composition as a feed pellet for the subject.
50 . The method according to claim 49 , wherein the subject is an animal selected from cattle, oxen, deer, goats, sheep, or pigs.
51 . The method according to claim 32 , further comprising administering the composition as a pellet mixed with or a liquid applied to a food for an animal.