METHODS FOR TREATING OR PREVENTING OPHTHALMOLOGICAL CONDITIONS
The present invention relates to methods for treating and preventing ophthalmological disease and disorders, comprising administering Antagonist A or another pharmaceutically acceptable salt thereof, optionally in combination with another treatment, to a subject in need thereof. The present invention also relates to methods for treating and preventing ophthalmological disease and disorders, comprising administering an anti-05 agent (e.g., ARC1905), optionally in combination with another treatment, to a subject in need thereof.
1 . (canceled)
2 . A method of treating geographic atrophy secondary to age-related macular degeneration in a human subject, the method comprising administering by intravitreal injection, to said subject, 2 mg/eye of a pegylated aptamer;
wherein the aptamer comprises the sequence fCmGfCfCGfCmGmGfUfCfUfCmAmGmGfCGfCfUmGmAmGfUfCfU mGmAmGfUfUfUAfCfCfUmGfCmG-3T (SEQ ID NO: 26),
wherein fC and fU=2′-fluoro nucleotides, mG and mA=2′-OMe nucleotides, all other nucleotides are 2′-OH, and 3T indicates an inverted deoxythymidine, or a salt thereof;
wherein the pegylated moiety has the following structure:
and
wherein the pegylated aptamer is administered to the subject monthly.
3 . The method of claim 2 , wherein the pegylated aptamer is administered in an aqueous solution further comprising one or more pH buffering agents and at least one tonicity adjuster.
4 . The method of claim 3 , where the one or more pH buffering agents comprise dibasic sodium phosphate heptahydrate and monobasic sodium phosphate monohydrate, and the at least one tonicity adjuster comprises sodium chloride.