Systems and methods for compensating for agent elution
A method for compensating for a life-lengthening agent for a glucose sensor includes accessing first and second electrochemical impedance spectroscopy (EIS) values of at least one parameter based on first and second EIS procedures performed on EIS signals from a working electrode of the glucose sensor, calculating a change in the at least one parameter between the first and second EIS values, estimating a concentration of the agent based on the change in the at least one parameter, and calculating a model effect in response to the concentration. In a case where the model effect is not greater than the threshold, the method further includes adjusting a sensor glucose value based on the concentration and sensor signals from the working electrode, and displaying the adjusted sensor glucose value.
1 . A method for compensating for an agent which lengthens a life of a glucose sensor monitoring a level of glucose in a body of a user, the glucose sensor including a first flex having a working electrode and a second flex being coated with the agent, the method comprising:
accessing a first electrochemical impedance spectroscopy (EIS) value of at least one parameter based on first EIS signals from the working electrode at an initiation time when the first flex and the second flex enter into the body of the user and the glucose sensor initiates sensing a level of glucose;
accessing a second EIS value of the at least one parameter based on second EIS signals from the working electrode at a second time after the initiation time;
calculating a change in the at least one parameter between the first EIS value and the second EIS value;
estimating a concentration of the agent based on the change in the at least one parameter;
calculating a model effect in response to the concentration;
determining whether the model effect is greater than a threshold; and
in a case where the model effect is determined to be greater than the threshold:
adjusting a sensor glucose value based on the concentration and sensor signals from the working electrode; and
displaying the adjusted sensor glucose value.
2 . The method of claim 1 , wherein the agent is selected from dexamethasone, dexamethasone phosphate, dexamethasone acetate, corticosteroids, NSAIDs, antifibrotic agents, or siRNA.
3 . The method of claim 1 , wherein the first and second EIS values are real impedance values at a specific frequency.
4 . The method of claim 3 , wherein the specific frequency is greater than or equal to 4 Hz.
5 . The method of claim 1 , further comprising:
removing an auto mode, which causes an insulin delivery device to automatically deliver insulin to the user based on the sensor glucose value, in a case where the model effect is determined to be greater than the threshold.
6 . The method of claim 1 , wherein determining whether the model effect in response to the concentration is greater than the threshold is performed by mapping the model effect to a confidence value, and
wherein the confidence value is within a confidence range.
7 . The method of claim 6 , wherein determining whether the model effect in response to the concentration is greater than the threshold is further performed by determining whether the confidence value falls within a predetermined range.
8 . The method of claim 7 , wherein the predetermined range is a subset of the confidence range.
9 . The method of claim 7 , further comprising:
in a case where it is determined that the confidence value does not fall within the predetermined range, blanking out the sensor glucose value.
10 . A glucose monitoring system comprising:
a glucose sensor including a first flex having a working electrode and a second flex being covered with an agent, which lengthens a lifetime of the glucose sensor, and monitoring a level of glucose in a body of a user; and
a controller configured to:
access a first electrochemical impedance spectroscopy (EIS) value of at least one parameter, the first EIS value based on first EIS signals from the working electrode at an initiation time when the first flex and the second flex enter into the body of the user and the glucose sensor initiates sensing a level of glucose;
access a second EIS value of the at least one parameter, the second EIS value based on second EIS signals from the working electrode at a second time after the initiation time;
calculate a change in the at least one parameter between the first EIS value and the second EIS value;
estimate a concentration of the agent based on the change in the at least one parameter;
determine whether a model effect in response to the concentration is greater than a threshold; and
in a case where the model effect is determined to be greater than the threshold:
adjust a sensor glucose value based on the concentration and sensor signals from the working electrode; and
display the adjusted sensor glucose value.
11 . The glucose monitoring system of claim 10 , wherein the agent is selected from dexamethasone, dexamethasone phosphate, dexamethasone acetate, corticosteroids, NSAIDs, antifibrotic agents, or siRNA.
12 . The glucose monitoring system of claim 10 , wherein the first and second EIS values are real impedance values at a specific frequency.
13 . The glucose monitoring system of claim 12 , wherein the specific frequency is greater than or equal to 4 Hz.
14 . The glucose monitoring system of claim 10 , wherein the controller is further configured to remove an auto mode, which causes an insulin delivery device to automatically deliver insulin to the user based on the sensor glucose value, in a case where the model effect is determined to be greater than the threshold.
15 . The glucose monitoring system of claim 10 , further comprising a display,
wherein the sensor glucose value is displayed on a screen of the display.
16 . The glucose monitoring system of claim 10 , wherein the controller determines whether the model effect in response to the concentration is greater than a threshold by:
mapping the model effect to a confidence value, and
wherein the confidence value is within a confidence range.
17 . The glucose monitoring system of claim 16 , wherein the controller determines whether the model effect in response to the concentration is greater than a threshold by further determining whether the confidence value falls within a predetermined range.
18 . The glucose monitoring system of claim 17 , wherein the predetermined range is a subset of the confidence range.
19 . The glucose monitoring system of claim 17 , wherein in a case where it is determined that the confidence value does not fall within the predetermined range, the controller is further configured to:
blank out the sensor glucose value.
20 . A non-transitory processor readable medium including instructions stored thereon which, when executed by a processor, causes performance of a method for compensating for an agent, which lengthens a lifetime of a glucose sensor monitoring a level of glucose in a body of a user, the glucose sensor including a first flex having a working electrode and a second flex being coated with the agent, the method comprising:
accessing a first electrochemical impedance spectroscopy (EIS) value of at least one parameter, the first EIS value based on first EIS signals from the working electrode at an initiation time when the first flex and the second flex enter into the body of the user and the glucose sensor initiates sensing a level of glucose;
accessing a second EIS value of the at least one parameter, the second EIS value based on second EIS signals from the working electrode at a second time after the initiation time;
calculating a change in the at least one parameter between the first EIS value and the second EIS value;
estimating a concentration of the agent based on the change in the at least one parameter;
calculating a model effect in response to the concentration;
determining whether the model effect is greater than a threshold; and
in a case where the model effect is determined not to be greater than the threshold:
adjusting a sensor glucose value based on the concentration and sensor signals from the working electrode; and
displaying the adjusted sensor glucose value.
21 . A glucose monitoring system comprising:
a glucose sensor including a flex having a working electrode and monitoring a level of glucose in a body of a user, wherein a portion of the flex is covered with an agent, which lengthens a lifetime of the glucose sensor; and
a controller configured to:
access a first electrochemical impedance spectroscopy (EIS) value of at least one parameter, the first EIS value based on first EIS signals from the working electrode at an initiation time when the flex enters into the body of the user and the glucose sensor initiates sensing a level of glucose;
access a second EIS value of the at least one parameter, the second EIS value based on second EIS signals from the working electrode at a second time after the initiation time;
calculate a change in the at least one parameter between the first EIS value and the second EIS value;
estimate a concentration of the agent based on the change in the at least one parameter;
determine whether a model effect in response to the concentration is greater than a threshold; and
in a case where the model effect is determined not to be greater than the threshold:
adjust a sensor glucose value based on the concentration; and
display the adjusted sensor glucose value.