Pharmaceutical suspensions for bismuth subsalicylates
The invention is directed to pharmaceutical compositions for suspending bismuth subsalicylate and methods of use thereof. Formulations of the present invention include at least three-gum systems to prevent the settling out of heavy particles in solution and do not include magnesium aluminum silicate. The pharmaceutical compositions may be used to treat gastrointestinal disorders.
1 . A pharmaceutical composition, wherein the composition is a three-gum system, consisting essentially of:
a) 17.5 mg/mL bismuth subsalicylate;
b) 2.9 mg/mL xanthan gum;
c) 1.5 mg/mL hydroxyethyl cellulose; and
d) 17.5 mg/mL a mixture of microcrystalline cellulose and carboxymethyl cellulose.
2 . A method of treating a gastrointestinal disorder in a patient in need thereof, comprising administering to the patient a composition according to claim 1 .
3 . The composition of claim 1 , wherein said composition has a sedimentation rate of from 0.001 mm/day to 0.015 mm/day at 23° C. as determined by x-ray measurement.
4 . The composition of claim 1 , wherein said composition has a viscosity of from 800 cps to 2400 cps, and the pH of the composition is from 4.0 to 5.5.