IP Library › Granted Patent US 12,303,716
Granted Patent B2
US 12,303,716 · App. 18/146,321 · Granted May 20, 2025

Methods for radiation delivery quality assurance

Inventors: Amir Ramezanzadeh Moghadam (San Jose, CA); George Andrew Zdasiuk (Portola Valley, CA)
Assignee: RefleXion Medical, Inc.
A61N5/1042A61N5/1045
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,303,716
App. No.
18/146,321
Granted
May 20, 2025
Kind
B2
Abstract

Described herein are methods and systems for generating a MV detector image for evaluating the quality of radiation delivery according to a radiotherapy treatment plan. The MV detector image is generated from MV detector measurements of a small number of multi-leaf collimator (MLC) leaf openings.

Claims (59)

1. A method for generating a radiation detector image that corresponds to a treatment plan fluence map multi-leaf opening pattern, the method comprising:

acquiring imaging data of a single leaf opening using a radiation source and a radiation detector for each leaf of a multi-leaf collimator (MLC);

acquiring imaging data of a double leaf opening using the radiation source and the radiation detector for each leaf of the MLC;

segmenting a treatment plan fluence map into a pattern of MLC openings; and

generating a radiation detector image that corresponds to the treatment plan fluence map by combining the acquired imaging data of single leaf and double leaf openings according to the pattern of MLC openings.

2. The method of claim 1 , further comprising generating a graphical representation that comprises the generated radiation detector image and outputting the graphical representation to a display device.

3. The method of claim 1 , further comprising calculating a radiation dose to a phantom based on the generated radiation detector image.

4. The method of claim 1 , wherein the radiation detector is a MV detector.

5. The method of claim 1 , wherein the radiation source and radiation detector are mounted on a gantry rotatable to multiple firing positions, and wherein acquiring imaging data of a single leaf opening and a double leaf opening comprises rotating the gantry to a first firing position and acquiring imaging data of a single leaf opening and a double leaf opening at the first firing position, and rotating the gantry to a second firing position and acquiring imaging data of a single leaf opening and a double leaf opening at the second firing position.

6. The method of claim 5 , further comprising acquiring imaging data of single leaf openings and double leaf openings for each leaf of the MLC at the first firing position.

7. The method of claim 6 , further comprising acquiring imaging data of single leaf openings and double leaf openings for each leaf of the MLC at the second firing position.

8. The method of claim 1 , wherein the pattern of MLC openings comprises a plurality of MLC leaf instructions designating leaf positions for each MLC leaf.

9. The method of claim 1 , wherein the pattern of MLC openings comprises a plurality of single leaf openings and a plurality of double leaf openings.

10. The method of claim 1 , wherein combining the acquired imaging data comprises summing the acquired imaging data of single leaf openings and the acquired imaging data of double leaf openings, and subtracting the imaging data of single leaf openings from areas of overlap in summed imaging data of double leaf openings.

11. The method of claim 1 , further comprising placing a phantom within a field of view of the radiation detector before acquiring radiation detector imaging data of single MLC leaf openings and double MLC leaf openings.

12. The method of claim 1 , further comprising placing a radiation fluence measurement device within a field of view of the radiation detector before acquiring radiation detector imaging data of single MLC leaf openings and double MLC leaf openings.

13. The method of claim 1 , wherein the acquired imaging data of single leaf openings, the acquired imaging data of double leaf openings, the pattern of MLC openings, and the generated radiation detector images are stored in a processor memory of a radiation delivery system.

14. The method of claim 1 , further comprising calculating a fill-in profile for each pair of adjacent MLC leaves by subtracting the imaging data of the two single MLC leaf openings from the imaging data of the corresponding double MLC leaf opening and wherein generating a radiation detector image that corresponds to the treatment plan fluence map comprises combining the acquired imaging data of single leaf openings and fill-in profiles according to the pattern of MLC openings.

15. The method of claim 14 , wherein combining the acquired imaging data of single leaf openings and the fill-in profiles comprises summing the acquired imaging data of single leaf openings and the fill-in profiles for adjacent single leaf openings.

16. The method of claim 14 , wherein generating the radiation detector image further comprises combining acquired imaging data of double leaf openings with the imaging data of single leaf openings and fill-in profiles.

17. The method of claim 14 , further comprising generating a graphical representation of the generated radiation detector image and outputting the graphical representation to a display device.

18. The method of claim 14 , further comprising calculating a radiation dose to a phantom based on the generated radiation detector image.

19. The method of claim 14 , wherein the radiation detector is an MV detector.

20. The method of claim 19 , wherein the radiation source and radiation detector are mounted on a gantry rotatable to multiple firing positions, and wherein acquiring imaging data of a single leaf opening and a double leaf opening comprises rotating the gantry to a first firing position and acquiring imaging data of a single leaf opening and a double leaf opening at the first firing position, and rotating the gantry to a second firing position and acquiring imaging data of a single leaf opening and a double leaf opening at the second firing position.

21. The method of claim 20 , further comprising acquiring imaging data of single leaf openings and double leaf openings for each leaf of the MLC at the first firing position.

22. The method of claim 21 , further comprising acquiring imaging data of single leaf openings and double leaf openings for each leaf of the MLC at the second firing position.

23. The method of claim 14 , wherein the pattern of MLC openings comprises a plurality of MLC leaf instructions designating leaf positions for each leaf of the MLC.

24. The method of claim 14 , wherein the pattern of MLC openings comprises a plurality of single leaf openings and a plurality of double leaf openings.

25. The method of claim 14 , further comprising placing a phantom within a field of view of the radiation detector before acquiring radiation detector imaging data of single MLC leaf openings and double MLC leaf openings.

26. The method of claim 14 , further comprising placing a radiation fluence measurement device within a field of view of the radiation detector before acquiring radiation detector imaging data of single MLC leaf openings and double MLC leaf openings.

27. The method of claim 14 , wherein the acquired imaging data of single leaf openings, the acquired imaging data of double leaf openings, the pattern of MLC openings, and the generated radiation detector images are stored in a processor memory of a radiation delivery system.

28. A radiotherapy system comprising a radiation source, a multi-leaf collimator (MLC), a radiation detector and one or more controllers, at least one of which is in communication with each of the radiation source, MLC and imaging system, wherein the controller is, or the controllers are between them, configured to perform the steps of:

acquiring imaging data of a single leaf opening using the radiation source and the radiation detector for each leaf of a multi-leaf collimator (MLC);

acquiring imaging data of a double leaf opening using the radiation source and the radiation detector for each leaf of the MLC;

segmenting a treatment plan fluence map into a pattern of MLC openings; and

generating a radiation detector image that corresponds to the treatment plan fluence map by combining the acquired imaging data of single leaf and double leaf openings according to the pattern of MLC openings.

29. The system of claim 28 , wherein the system further comprises a display device and the controller is further configured to generate a graphical representation that comprises the generated radiation detector image and output the graphical representation to the display device.

30. The system of claim 28 , wherein the one or more controllers is further configured to calculate a radiation dose to a phantom based on the generated radiation detector image.

31. The system of claim 28 , wherein the radiation detector is a MV detector.

32. The system of claim 28 , wherein the radiation source and radiation detector are mounted on a gantry rotatable to multiple firing positions, a first of the one or more controllers being configured to acquire imaging data of a single leaf opening and a double leaf opening by rotating the gantry to a first firing position and using the radiation source and the radiation detector to acquire imaging data of a single leaf opening and a double leaf opening at the first firing position, rotating the gantry to a second firing position and using the radiation source and the radiation detector to acquire imaging data of a single leaf opening and a double leaf opening at the second firing position.

33. The system of claim 32 , wherein the first controller is further configured to acquire imaging data of single leaf openings and double leaf openings for each leaf of the MLC at the first firing position.

34. The system of claim 33 , wherein the first controller is further configured to acquire imaging data of single leaf openings and double leaf openings for each leaf of the MLC at the second firing position.

35. The system of claim 28 , wherein the pattern of MLC openings comprises a plurality of MLC leaf instructions designating leaf positions for each MLC leaf.

36. The system of claim 28 , wherein the pattern of MLC openings comprises a plurality of single leaf openings and a plurality of double leaf openings.

37. The system of claim 28 , wherein combining the acquired imaging data comprises summing the acquired imaging data of single leaf openings and the acquired imaging data of double leaf openings, and subtracting the imaging data of single leaf openings from areas of overlap in summed imaging data of double leaf openings.

38. The system of claim 28 , wherein the system further comprises a processor memory and the acquired imaging data of single leaf openings, the acquired imaging data of double leaf openings, the pattern of MLC openings, and the generated radiation detector images are stored in the processor memory.

39. The system of claim 28 , wherein the one or more controllers is further configured to calculate a fill-in profile for each pair of adjacent MLC leaves by subtracting the imaging data of the two single MLC leaf openings from the imaging data of the corresponding double MLC leaf opening and wherein generating the radiation detector image that corresponds to the treatment plan fluence map comprises combining the acquired imaging data of single leaf openings and fill-in profiles according to the pattern of MLC openings.

40. The system of claim 39 , wherein combining the acquired imaging data of single leaf openings and the fill-in profiles comprises summing the acquired imaging data of single leaf openings and the fill-in profiles for adjacent single leaf openings.

41. The system of claim 39 , wherein generating the radiation detector image further comprises combining acquired imaging data of double leaf openings with the imaging data of single leaf openings and fill-in profiles.

42. The system of claim 39 , wherein the system further comprises a display device and the controller is further configured to generate a graphical representation of the generated radiation detector image and output the graphical representation to the display device.

43. The system of claim 39 , wherein a second of the one or more controllers is further configured to calculate a radiation dose to a phantom based on the generated radiation detector image.

44. The system of claim 39 , wherein the radiation detector is an MV detector.

45. The system of claim 28 , wherein the radiation source and radiation detector are mounted on a gantry rotatable to multiple firing positions, the one or more controllers being configured to acquire imaging data of a single leaf opening and a double leaf opening by rotating the gantry to a first firing position and acquiring imaging data of a single leaf opening and a double leaf opening at the first firing position, and rotating the gantry to a second firing position and acquiring imaging data of a single leaf opening and a double leaf opening at the second firing position.

46. The system of claim 45 , wherein the one or more controllers is further configured to acquire imaging data of single leaf openings and double leaf openings for each leaf of the MLC at the first firing position.

47. The system of claim 46 , wherein the one or more controllers is further configured to acquire imaging data of single leaf openings and double leaf openings for each leaf of the MLC at the second firing position.

48. The system of claim 39 , wherein the pattern of MLC openings comprises a plurality of MLC leaf instructions designating leaf positions for each leaf of the MLC.

49. The system of claim 39 , wherein the pattern of MLC openings comprises a plurality of single leaf openings and a plurality of double leaf openings.

50. The system of claim 39 , wherein the one or more controllers comprises a processor memory and the acquired imaging data of single leaf openings, the acquired imaging data of double leaf openings, the pattern of MLC openings, and the generated radiation detector images are stored in the processor memory.

51. The system of claim 28 , wherein the one or more controllers comprise a first controller that is in communication with each of the radiation source, MLC and imaging system and a second controller, and a second controller, wherein the first controller is configured to perform the steps of acquiring imaging data of a single leaf opening using the radiation source and the radiation detector for each leaf of the MLC and acquiring imaging data of a double leaf opening using the radiation source and the radiation detector for each leaf of the MLC, and wherein the second controller is configured to perform the steps of segmenting a treatment plan fluence map into a pattern of MLC openings and generating a radiation detector image that corresponds to the treatment plan fluence map by combining the acquired imaging data of single leaf and double leaf openings according to the pattern of MLC openings.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 20, 2023
From: RAMEZANZADEH MOGHADAM, AMIR; ZDASIUK, GEORGE ANDREW
To: REFLEXION MEDICAL, INC.
Reel/Frame 063393/0972 →
Continuity (2)
Provisional Application 63294047 · Dec 27, 2021
Related Publication 20230201629A1 · Jun 29, 2023
References Cited (197)
US 3418475A · Hudgens · 1968 [cited by applicant]
US 3668399A · Cahill et al. · 1972 [cited by applicant]
US 3721826A · Thomas, Jr. · 1973 [cited by applicant]
US 3779135A · Sugimura · 1973 [cited by applicant]
US 3936647A · Fekete · 1976 [cited by applicant]
US 4086494A · Malak · 1978 [cited by applicant]
US 4241644A · Schertler · 1980 [cited by applicant]
US 4246488A · Hura · 1981 [cited by applicant]
US 4361902A · Brandt et al. · 1982 [cited by applicant]
US 4527769A · Stogner et al. · 1985 [cited by applicant]
US 4628499A · Hammett · 1986 [cited by applicant]
US 4760589A · Siczek · 1988 [cited by applicant]
US 4794629A · Pastyr et al. · 1988 [cited by applicant]
US 5010312A · Motykiewicz · 1991 [cited by applicant]
US 5317616A · Swerdloff et al. · 1994 [cited by applicant]
US 5351280A · Swerdloff et al. · 1994 [cited by applicant]
US 5394452A · Swerdloff et al. · 1995 [cited by applicant]
US 5408591A · Shih et al. · 1995 [cited by applicant]
US 5495376A · Wasson et al. · 1996 [cited by applicant]
US 5596619A · Carol · 1997 [cited by applicant]
US 5757881A · Hughes · 1998 [cited by applicant]
US 6052436A · Huttner et al. · 2000 [cited by applicant]
US 6137114A · Rohe et al. · 2000 [cited by applicant]
US 6449340B1 · Tybinkowski et al. · 2002 [cited by applicant]
US 6895751B1 · Greentree · 2005 [cited by applicant]
US 7519162B2 · Hoffmann · 2009 [cited by applicant]
US 7783007B2 · Echner · 2010 [cited by applicant]
US 8017915B2 · Mazin · 2011 [cited by applicant]
US 8107589B2 · Sakurai et al. · 2012 [cited by applicant]
US 8605857B1 · Renner · 2013 [cited by applicant]
US 9019307B1 · Grimm · 2015 [cited by applicant]
US 9443633B2 · Orton et al. · 2016 [cited by applicant]
US 10456600B2 · Owens et al. · 2019 [cited by applicant]
US 10500416B2 · Larkin et al. · 2019 [cited by applicant]
US 10695586B2 · Harper et al. · 2020 [cited by applicant]
US 10702715B2 · Pearce et al. · 2020 [cited by applicant]
US 11285340B2 · Larkin et al. · 2022 [cited by applicant]
US 20040030246A1 · Townsend et al. · 2004 [cited by applicant]
US 20040079899A1 · Ma · 2004 [cited by applicant]
US 20040122308A1 · Ding · 2004 [cited by applicant]
US 20050063516A1 · Kato et al. · 2005 [cited by applicant]
US 20050197564A1 · Dempsey · 2005 [cited by applicant]
US 20060113482A1 · Pelizzari et al. · 2006 [cited by applicant]
US 20060173294A1 · Ein-Gal · 2006 [cited by applicant]
US 20060193441A1 · Cadman · 2006 [cited by applicant]
US 20060272494A1 · Cetinkunt et al. · 2006 [cited by applicant]
US 20070164239A1 · Terwilliger et al. · 2007 [cited by applicant]
US 20070251379A1 · Lund · 2007 [cited by applicant]
US 20080035870A1 · Wygnanski et al. · 2008 [cited by applicant]
US 20080165930A1 · Perkins · 2008 [cited by applicant]
US 20090200476A1 · Brusasco et al. · 2009 [cited by applicant]
US 20090256078A1 · Mazin · 2009 [cited by applicant]
US 20100040197A1 · Maniawski et al. · 2010 [cited by applicant]
US 20100054408A1 · Echner · 2010 [cited by applicant]
US 20110049377A1 · Morf et al. · 2011 [cited by applicant]
US 20110200170A1 · Nord et al. · 2011 [cited by applicant]
US 20110210261A1 · Maurer, Jr. · 2011 [cited by applicant]
US 20120035470A1 · Kuduvalli et al. · 2012 [cited by applicant]
US 20120203490A1 · Sayeh et al. · 2012 [cited by applicant]
US 20120213334A1 · Dirauf et al. · 2012 [cited by applicant]
US 20120234023A1 · Mizuno · 2012 [cited by applicant]
US 20120250971A1 · Holmes et al. · 2012 [cited by applicant]
US 20120317994A1 · Matsubara · 2012 [cited by applicant]
US 20130251109A1 · Becca et al. · 2013 [cited by applicant]
US 20140079179A1 · Takagaki et al. · 2014 [cited by applicant]
US 20140239204A1 · Orton et al. · 2014 [cited by applicant]
US 20140270053A1 · Larson · 2014 [cited by applicant]
US 20150126801A1 · Matteo et al. · 2015 [cited by applicant]
US 20150150740A1 · Lewald et al. · 2015 [cited by applicant]
US 20150170778A1 · Echner et al. · 2015 [cited by applicant]
US 20150190658A1 · Yu · 2015 [cited by applicant]
US 20150224342A1 · Baltes et al. · 2015 [cited by applicant]
US 20150283403A1 · Kapatoes et al. · 2015 [cited by applicant]
US 20150360056A1 · Xing et al. · 2015 [cited by applicant]
US 20160140300A1 · Purdie et al. · 2016 [cited by applicant]
US 20160193480A1 · Ribbing et al. · 2016 [cited by applicant]
US 20160361566A1 · Larkin et al. · 2016 [cited by applicant]
US 20160361568A1 · Chappelow et al. · 2016 [cited by applicant]
US 20170095678A1 · Oster et al. · 2017 [cited by applicant]
US 20180185672A1 · Ramezanzadeh Moghadam · 2018 [cited by applicant]
US 20180345042A1 · Voronenko et al. · 2018 [cited by applicant]
US 20180369611A1 · Owens et al. · 2018 [cited by applicant]
US 20190054320A1 · Owens et al. · 2019 [cited by applicant]
US 20200197729A1 · Owens et al. · 2020 [cited by applicant]
US 20200368557A1 · Harper et al. · 2020 [cited by applicant]
US 20210011178A1 · Kapatoes · 2021 [cited by applicant]
US 20220001209A1 · Owens et al. · 2022 [cited by applicant]
US 20220193451A1 · Duval et al. · 2022 [cited by applicant]
CN 2529663Y · 2003 [cited by applicant]
CN 1799509A · 2006 [cited by applicant]
CN 101267767A · 2008 [cited by applicant]
CN 101297759A · 2008 [cited by applicant]
CN 101378805A · 2009 [cited by applicant]
CN 101908348A · 2010 [cited by applicant]
CN 102467985A · 2012 [cited by applicant]
CN 102755696A · 2012 [cited by applicant]
CN 102760505A · 2012 [cited by applicant]
CN 202620505U · 2012 [cited by applicant]
CN 103071241A · 2013 [cited by applicant]
CN 103209736A · 2013 [cited by applicant]
CN 103650095A · 2014 [cited by applicant]
CN 104519958A · 2015 [cited by applicant]
DE 102013205606A1 · 2014 [cited by applicant]
EP 0437434A1 · 1995 [cited by applicant]
EP 0817978A1 · 2001 [cited by applicant]
EP 1762177A2 · 2007 [cited by applicant]
EP 2072081A1 · 2009 [cited by applicant]
EP 2708919A2 · 2014 [cited by applicant]
EP 2904974A1 · 2015 [cited by applicant]
EP 2872913B1 · 2016 [cited by applicant]
EP 2990078A1 · 2016 [cited by applicant]
FR 2839894A1 · 2003 [cited by applicant]
GB 2341301A · 2000 [cited by applicant]
GB 69634119T2 · 2006 [cited by applicant]
GB 2513596A · 2014 [cited by applicant]
JP H01156830A · 1989 [cited by applicant]
JP H08511451A · 1996 [cited by applicant]
JP H09122110A · 1997 [cited by applicant]
JP 2002263090A · 2002 [cited by applicant]
JP 03277350A · 2003 [cited by applicant]
JP 2008173184A · 2008 [cited by applicant]
JP 2009160308A · 2009 [cited by applicant]
JP 2009538195A · 2009 [cited by applicant]
JP 2010500910A · 2010 [cited by applicant]
JP 2013059576A · 2013 [cited by applicant]
JP 2013545560A · 2013 [cited by applicant]
JP 2014503315A · 2014 [cited by applicant]
JP 2014521370A · 2014 [cited by applicant]
JP 2016055161A · 2016 [cited by applicant]
NL 9520013A · 1997 [cited by applicant]
WO WO0059576A1 · 2000 [cited by applicant]
WO WO2010109585A1 · 2010 [cited by applicant]
WO WO2012135771A1 · 2012 [cited by applicant]
WO WO2013024380A1 · 2013 [cited by applicant]
WO WO2015038832A1 · 2015 [cited by applicant]
WO WO2015103564A1 · 2015 [cited by applicant]
WO WO2015134953A1 · 2015 [cited by applicant]
WO WO2015161036A1 · 2015 [cited by applicant]
WO WO2016172352A1 · 2016 [cited by applicant]
WO WO2017081768A1 · 2017 [cited by applicant]
WO WO2018183748A1 · 2018 [cited by applicant]
WO WO2020144134A1 · 2020 [cited by applicant]
WO WO2021011207A1 · 2021 [cited by applicant]
WO WO2022036707A1 · 2022 [cited by applicant]
WO WO2022144538A1 · 2022 [cited by applicant]
WO WO2022182681 · 2022 [cited by applicant]
Extended European Search Report mailed on Mar. 18, 2019, for European Patent Application No. 16 808 458.0, filed on Jun. 10, 2016, 8 pages. [cited by applicant]
Extended European Search Report mailed on Jun. 9, 2020, for EP Application No. 17 871 349.1, filed on Nov. 15, 2017, 6 pages. [cited by applicant]
Extended European Search Report mailed on Mar. 15, 2021, for EP Application No. 18 837 615.6, filed on Jul. 26, 2018, 8 pages. [cited by applicant]
Extended European Search Report mailed on Mar. 30, 2022, for EP Application No. 21 195 331.0, filed on Nov. 15, 2017, 11 pages. [cited by applicant]
Fan, Q. et al. (2012). “Emission Guided Radiation Therapy for Lung and Prostrate Cancers: A Feasibility Study on a Digital Patient,” [cited by applicant]
Fan, Q. et al. (2013). “Toward a Planning Scheme for Emission Guided Radiation Therapy (EGRT): FDG Based Tumor Tracking in a Metastatic Breast Cancer Patient,” [cited by applicant]
Final Office Action mailed on Nov. 1, 2018, for U.S. Appl. No. 15/179,823, filed Jun. 10, 2016, 12 pages. [cited by applicant]
Final Office Action mailed on Jul. 14, 2021, for U.S. Appl. No. 16/582,308, filed Sep. 25, 2019, 8 pages. [cited by applicant]
Final Office Action mailed on Sep. 15, 2022, for U.S. Appl. No. 16/582,308, filed Sep. 25, 2019, 10 pages. [cited by applicant]
Internal Atomic Energy Agency (Oct. 2008). “The Role of PET/CT in Radiation Treatment Planning for Cancer Patient Treatment,” located at https://www-pub.iaea.org/MTCD/Publications/PDF/te_1603_web.pdf, 40 total pages. [cited by applicant]
International Search Report mailed on Sep. 16, 2016, for PCT Application No. PCT/US2016/037051, filed on Jun. 10, 2016, 3 pages. [cited by applicant]
International Search Report mailed on Mar. 7, 2018, for PCT Application No. PCT/US2017/061848, filed on Nov. 15, 2017, 4 pages. [cited by applicant]
International Search Report mailed on Oct. 3, 2018, for PCT Application No. PCT/US2018/043954, filed on Jul. 26, 2018, 3 pages. [cited by applicant]
International Search Report mailed on Aug. 24, 2022, for PCT Application No. PCT/US2022/017375, filed on Feb. 22, 2022, 7 pages. [cited by applicant]
International Search Report mailed on Feb. 23, 2023, for PCT Application No. PCT/US2022/079175, filed on Nov. 2, 2022, 6 pages. [cited by applicant]
Islam, M.K. (2009). “An integral quality monitoring system for real-time verification of intensity modulated radiation therapy,” Med. Phys. 36:5420-5428. [cited by applicant]
Merriam-Webster Dictionary (2018). “Couple,” located at https://web.archive.org/web/20150403230112/https://www.merriam-webster.com/dictionary/couple. [cited by applicant]
Muller, L. (May 2018). “Maritimes an der waterkant,” Neus von Dolphin & Compass, Presentation, 53 total pages. [cited by applicant]
Non-Final Office Action mailed on Aug. 30, 2018, for U.S. Appl. No. 15/179,823, filed Jun. 10, 2016, 11 pages. [cited by applicant]
Non-Final Office Action mailed on Mar. 8, 2019, for U.S. Appl. No. 15/179,823, filed Jun. 10, 2016, 11 pages. [cited by applicant]
Non-Final Office Action mailed on Jan. 7, 2020, for U.S. Appl. No. 15/814,222, filed Nov. 15, 2017, 13 pages. [cited by applicant]
Non-Final Office Action mailed on Feb. 11, 2021, for U.S. Appl. No. 16/582,308, filed Sep. 25, 2019, 9 pages. [cited by applicant]
Non-Final Office Action mailed on May 5, 2021, for U.S. Appl. No. 16/677,200, filed Nov. 7, 2019, 15 pages. [cited by applicant]
Non-Final Office Action mailed on Jun. 8, 2022, for U.S. Appl. No. 16/582,308, filed Sep. 25, 2019, 9 pages. [cited by applicant]
Non-Final Office Action mailed on Dec. 14, 2022, for U.S. Appl. No. 16/887,852, filed May 29, 2020, 12 pages. [cited by applicant]
Notice of Allowance mailed on Jul. 25, 2019, for U.S. Appl. No. 16/046,746, filed Jul. 26, 2018, 8 pages. [cited by applicant]
Notice of Allowance mailed on Aug. 15, 2019, for U.S. Appl. No. 16/046,746, filed Jul. 26, 2018, 7 pages. [cited by applicant]
Notice of Allowance mailed on Sep. 23, 2019, for U.S. Appl. No. 15/179,823, filed Jun. 10, 2016, 10 pages. [cited by applicant]
Notice of Allowance mailed on Apr. 30, 2020, for U.S. Appl. No. 15/814,222, filed Nov. 15, 2017, 10 pages. [cited by applicant]
Notice of Allowance mailed on Oct. 28, 2021, for U.S. Appl. No. 16/677,200, filed Nov. 7, 2019, 11 pages. [cited by applicant]
Shirvani, S.M. et al. (Jan. 2021). “Biology-guided radiotherapy: redefining the role of radiotherapy in metastatic cancer,” Br. J. Radiol. 94:20200873, 10 total pages. [cited by applicant]
Thorwarth, D. et al. (2010). “Physical radiotherapy treatment planning based on functional PET/CT data,” Radiotherapy Oncology, pp. 317-324. [cited by applicant]
Written Opinion of the International Searching Authority mailed on Sep. 16, 2016, for PCT Application No. PCT/US2016/037051, filed on Jun. 10, 2016, 5 pages. [cited by applicant]
Written Opinion of the International Searching Authority mailed on Mar. 7, 2018, for PCT Application No. PCT/US2017/061848, filed on Nov. 15, 2017, 5 pages. [cited by applicant]
Written Opinion of the International Searching Authority mailed on Oct. 3, 2018, for PCT Application No. PCT/US2018/043954, filed on Jul. 26, 2018, 5 pages. [cited by applicant]
Written Opinion of the International Searching Authority mailed on Aug. 24, 2022, for PCT Application No. PCT/US2022/017375, filed on Feb. 22, 2022, 11 pages. [cited by applicant]
Written Opinion of the International Searching Authority mailed on Feb. 23, 2023, for PCT Application No. PCT/US2022/079175, filed on Nov. 2, 2022, 9 pages. [cited by applicant]
Corrected Notice of Allowability mailed on Jan. 30, 2024, for U.S. Appl. No. 16/887,852, filed May 29, 2020, 2 pages. [cited by applicant]
Final Office Action mailed on Oct. 4, 2023, for U.S. Appl. No. 17/479,873, filed Sep. 20, 2021, 10 pages. [cited by applicant]
Final Office Action mailed on Jul. 8, 2024, for U.S. Appl. No. 17/479,873, filed Sep. 20, 2021, 11 pages. [cited by applicant]
International Search Report mailed on May 9, 2023, for PCT Application No. PCT/US2022/082375, filed on Dec. 23, 2022, 4 pages. [cited by applicant]
International Search Report mailed on Jun. 6, 2024, for PCT Application No. PCT/US2023/085347, filed on Dec. 21, 2023, 6 pages. [cited by applicant]
Non-Final Office Action mailed on Jun. 29, 2023, for U.S. Appl. No. 17/479,873, filed Sep. 20, 2021, 10 pages. [cited by applicant]
Non-Final Office Action mailed on Mar. 5, 2024, for U.S. Appl. No. 17/479,873, filed Sep. 20, 2021, 11 pages. [cited by applicant]
Notice of Allowance mailed on Oct. 16, 2023, for U.S. Appl. No. 17/566,212, filed Dec. 30, 2021, 12 pages. [cited by applicant]
Notice of Allowance mailed on Dec. 28, 2023, for U.S. Appl. No. 16/887,852, filed May 29, 2020, 9 pages. [cited by applicant]
Notice of Allowance mailed on Jan. 15, 2025, for U.S. Appl. No. 17/479,873, filed Sep. 20, 2021, 9 pages. [cited by applicant]
Notice of Allowance mailed on Feb. 19, 2025, for U.S. Appl. No. 17/479,873, filed Sep. 20, 2021, 5 pages. [cited by applicant]
Samant, S.S. et al. (Dec. 2002). “Verification of multileaf collimator leaf positions using an electronic portal imaging device,” Med. Phys. 29(12):2900-2912. [cited by applicant]
Written Opinion of the International Searching Authority mailed on May 9, 2023, for PCT Application No. PCT/US2022/082375, filed on Dec. 23, 2022, 5 pages. [cited by applicant]
Written Opinion of the International Searching Authority mailed on Jun. 6, 2024, for PCT Application No. PCT/US2023/085347, filed on Dec. 21, 2023, 10 pages. [cited by applicant]