Inhibiting viral infection using alternating electric fields
Viral infections in a target region can be inhibited by imposing an alternating electric field in the target region for a duration of time. The alternating electric field has a frequency and a field strength such that when the alternating electric field is imposed in the target region for the duration of time, the alternating electric field inhibits infection of the cells in the target region by the virus. Optionally, the inhibition of viral infections using the alternating electric field approach can be combined with delivering an antiviral agent to the target region so that a therapeutically effective dose of the antiviral agent is present in the target region while the alternating electric fields are imposed.
1. A method of treating a subject having a viral infection, comprising the steps of:
applying an alternating electric field to a target region of the subject for a duration of time, the alternating electric field having a frequency and a field strength, wherein the alternating electric field inhibits viral infection of cells in the target region wherein the target region is tumor-free.
2. The method of claim 1 , further comprising the step of delivering an antiviral agent to the subject.
3. The method of claim 1 , wherein the alternating electric field has a frequency between 50 and 500 kHz.
4. The method of claim 1 , wherein the alternating electric field has a frequency between 25 kHz and 1 MHz.
5. The method of claim 1 , wherein the alternating electric field has a frequency of about 200 kHz.
6. The method of claim 1 , wherein the alternating electric field has a field strength between 1 and 5 V/cm RMS.
7. The method of claim 1 , wherein the alternating electric field has a field strength of about 1.2 V/cm RMS.
8. The method of claim 1 , wherein the duration of time is between 1 and 48 hours.
9. The method of claim 1 , wherein the duration of time is between 2 and 14 days.
10. The method of claim 1 , wherein the duration of time is about 48 hours.
11. The method of claim 1 , wherein the alternating electric field has an orientation that is repeatedly switched between at least two directions during the duration of time.
12. The method of claim 11 , wherein the orientation of the alternating electric field is switched about once a second.
13. The method of claim 1 , wherein the alternating electric field has an orientation that is repeatedly switched between a first direction and a second direction during the duration of time, wherein the first direction is roughly perpendicular to the second direction.
14. The method of claim 1 , wherein the alternating electric field is applied to the target region via capacitively coupled electrodes.
15. The method of claim 2 , wherein a therapeutically effective dose of the antiviral agent is present in the target region while the imposing is performed.