Granted Patent B2

US 12,691,222 · App. 18/164,669 · Granted Jul 28, 2026

Inventors: Joon Bok Lee (Acton, MA); James Graham (Tyngsboro, MA); Jason O'Connor (Acton, MA); Yibin Zheng (Hartland, WI)

Assignee: INSULET CORPORATION

A61M5/1723G16H20/17A61M2202/0486A61M2205/52

Abstract

Claims (336)

1 . A controller for operating an insulin delivery device, comprising:

a processor; and

a memory storing instructions that, when executed by the processor, operate the controller to:

determine an insulin action (I action ) for a patient over a duration, the insulin action representing a total insulin metabolized;

determine glucose information for the patient over the duration, the glucose information representing glucose activity, wherein the glucose activity is calculated based on the meal ingestion during the duration versus the residual meal that is unabsorbed; and

determine an estimated correction factor (CF est ) based on (glucose information)/(insulin action) for the duration, wherein the estimated correction factor is used by the insulin delivery device to deliver an amount of insulin.

2 . The controller of claim 1 , the I action determined based on an insulin decay curve for the duration.

3 . The controller of claim 2 , the I action determined using the following:

I

action

(

i

)

=

(

∑

k

=

1

n

⁢

I

(

i

-

k

)

)

-

IOB

⁡

(

i

)

,

where n is determined based on (duration)/(duration increments).

4 . The controller of claim 1 , the glucose information comprising a glucose action (G action ) value.

5 . The controller of claim 4 , the G action determined using the following:

G

action

(

i

)

=

1

4

⁢

8

⁢

∑

k

=

1

4

⁢

8

⁢

(

G

⁡

(

i

-

k

)

-

x

)

,

where x is a target glucose value.

6 . The controller of claim 4 , the glucose information comprising a glucose meal excursion value (G meal ).

7 . The controller of claim 6 , the Great value determined using the following:

G

m

⁢

e

⁢

a

⁢

l

(

i

)

=

(

∑

k

=

1

4

⁢

8

⁢

CHO

⁡

(

i

-

k

)

-

C

⁢

O

⁢

B

⁡

(

i

)

)

·

M

f

,

where CHO is all carbohydrates ingested, COB is carbohydrates-on-board, and M f is a meal factor.

8 . The controller of claim 1 , the instructions, when executed by the processor, to operate the controller to determine a final correction factor (CF final ) based on CF est using the following:

C

⁢

F

f

⁢

i

⁢

n

⁢

a

⁢

l

(

i

)

=

0.8

·

1

⁢

8

⁢

0

⁢

0

∑

k

=

1

2

⁢

4

⁢

4

⁢

I

⁡

(

i

-

k

)

+

0.2

·

CF

est

(

i

)

.

9 . The controller of claim 1 , the duration comprising about 4 hours.

10 . A method for operating a drug delivery device, comprising, via a processor of a controller:

determining an insulin action (I action ) for a patient over a duration, the insulin action representing a total insulin metabolized;

determining glucose information for the patient over the duration, the glucose information representing glucose activity, wherein the glucose activity is calculated based on the meal ingestion during the duration versus the residual meal that is unabsorbed; and

determining an estimated correction factor (CF est ) based on (glucose information)/(insulin action) for the duration, wherein the estimated correction factor is used by the insulin delivery device to deliver an amount of insulin.

11 . The method of claim 10 , the I action determined based on an insulin decay curve for the duration.

12 . The method of claim 11 , the I action determined using the following:

I

action

(

i

)

=

(

∑

k

=

1

n

⁢

I

(

i

-

k

)

)

-

IOB

⁡

(

i

)

,

where n is determined based on (duration)/(duration increments).

13 . The method of claim 12 , the glucose information comprising a glucose action (G action ) value.

14 . The method of claim 13 , the G action determined using the following:

G

action

(

i

)

=

1

4

⁢

8

⁢

∑

k

=

1

4

⁢

8

⁢

(

G

⁡

(

i

-

k

)

-

x

)

,

where x is a target glucose value.

15 . The method of claim 13 , the glucose information comprising a glucose meal excursion value (G meal ).

16 . The method of claim 15 , the G meal value determined using the following:

G

m

⁢

e

⁢

a

⁢

l

(

i

)

=

(

∑

k

=

1

4

⁢

8

⁢

CHO

⁡

(

i

-

k

)

-

C

⁢

O

⁢

B

⁡

(

i

)

)

·

M

f

,

where CHO is all carbohydrates ingested, COB is carbohydrates-on-board, and M f is a meal factor.

17 . The method of claim 10 , comprising determining a final correction factor (CF final ) based on CF est using the following:

C

⁢

F

f

⁢

i

⁢

n

⁢

a

⁢

l

(

i

)

=

0.8

·

1

⁢

8

⁢

0

⁢

0

∑

k

=

1

2

⁢

4

⁢

4

⁢

I

⁡

(

i

-

k

)

+

0.2

·

CF

est

(

i

)

.

18 . The method of claim 10 , the duration comprising about 4 hours.

Assignments (2)

Continuity (2)

References Cited (400)