COLLAGEN 7 COMPOSITIONS AND METHODS OF USING THE SAME
The present disclosure relates to compositions comprising collagen 7 and methods of using the same to treat DEB.
1 . A composition comprising at least 0.5 mg/ml recombinant collagen 7 (rCol7) in a formulation comprising arginine.
2 . The composition of claim 1 , wherein rCol7 is at a concentration of about 1.0 mg/ml to about 4.0 mg/ml.
3 . The composition of claim 2 , wherein rCol 7 is at a concentration of about 1.0 mg/ml to about 2.0 mg/ml.
4 . The composition of claim 3 , wherein the formulation further comprises 10 mM sodium phosphate, 5 mM sodium citrate, 70 mM sodium chloride, 100 mM arginine, 50 mM sucrose and 0.05% (v/v) polysorbate 20.
5 . The composition of claim 4 for use of medicine administered to a subject in need through infusion wherein the infusion lasts at least 60 minutes.
6 . A method for treating dystrophic epidermolysis bullosa comprising administering to a subject in need thereof an effective amount of a composition of claim 1 .
7 . The method of claim 6 wherein the composition is administrated to the subject in need by intravenous administration.
8 . A method for increasing closure between epidermis and dermis of the wounded skin in a subject comprising administering to the subject a composition comprising a recombinant collagen 7 in an arginine containing formulation.
9 . The method of claim 8 wherein the composition is administrated to the subject in need by intravenous administration.
10 . A method for treating dystrophic epidermolysis bullosa comprising administering to a subject in need thereof an effective amount of a composition of claim 2 .
11 . The method of claim 10 wherein the composition is administrated to the subject in need by intravenous administration.
12 . A method for treating dystrophic epidermolysis bullosa comprising administering to a subject in need thereof an effective amount of a composition of claim 3 .
13 . The method of claim 12 wherein the composition is administrated to the subject in need by intravenous administration.
14 . A method for treating dystrophic epidermolysis bullosa comprising administering to a subject in need thereof an effective amount of a composition of claim 4 .
15 . The method of claim 14 wherein the composition is administrated to the subject in need by intravenous administration.
16 . A method for treating dystrophic epidermolysis bullosa comprising administering to a subject in need thereof an effective amount of a composition of claim 5 .
17 . The method of claim 16 wherein the composition is administrated to the subject in need by intravenous administration.