IP Library › Granted Patent US 12,180,248
Granted Patent B2
US 12,180,248 · App. 18/169,964 · Granted Dec 31, 2024

Compositions and methods for treating CNS disorders

Inventors: Gabriel Martinez Botella (Wayland, MA); Francesco G. Salituro (Marlborough, MA); Albert Jean Robichaud (Boston, MA); Boyd L. Harrison (Princeton Junction, NJ)
Assignee: Sage Therapeutics, Inc.
C07J43/003A61K9/0019A61K9/0053A61K31/58A61P25/00C07D231/14C07D249/04C07D249/18C07D295/033C07J9/00C07J13/007C07J75/00
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,180,248
App. No.
18/169,964
Granted
Dec 31, 2024
Kind
B2
Abstract

Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein, R 1 , R 2a , R 2b , R 3 and A are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

Claims (5)

1. A compound having the structure

or a pharmaceutically acceptable salt thereof.

2. A process for preparing a compound of Formula (A17) or Formula (A18):

comprising treating a compound of Formula (A16)

with HBr and Br 2 , wherein the process is performed in MeOH at room temperature.

Assignments (2)
CHANGE OF NAME Recorded Apr 23, 2026
From: SAGE THERAPEUTICS, INC.
To: SAGE THERAPEUTICS, LLC
Reel/Frame 075472/0569 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 16, 2023
From: MARTINEZ BOTELLA, GABRIEL; SALITURO, FRANCESCO G.; ROBICHAUD, ALBERT JEAN; HARRISON, BOYD L.
To: SAGE THERAPEUTICS, INC.
Reel/Frame 062998/0271 →