Methods for monitoring ablation progress with doppler ultrasound
Systems and methods for treating tissue are disclosed. The target tissue is ablated. A real-time image of the target tissue is generated during the ablation. The real-time blood perfusion level of the target tissue is determined from the real-time image and compared to an initial blood perfusion level of the target tissue. The comparison provides a metric for the progress of the ablation, and ablation is halted when the real-time blood perfusion drops below a threshold level relative to the initial blood perfusion level.
1. A system for treating a target tissue, the system comprising:
a treatment probe comprising a handle, a probe body, an imaging source coupled to the probe body, and an ablation element coupled to the probe body and configured to ablate the target tissue;
a real-time display coupled to the treatment probe; and
a controller coupled to the imaging source of the treatment probe and the real-time display, the controller comprising a computer readable, non-transient storage medium comprising:
(i) instructions for the imaging source to generate a real-time image of the target tissue during ablation of the target tissue,
(ii) instructions for the real-time display to display the real-time image, the real-time image showing the target tissue and a virtual treatment boundary around the target tissue,
(iii) instructions for determining an initial blood perfusion of the target tissue,
(iv) instructions for, prior to initiating ablation of the target tissue, modifying one or more of a size or location of the virtual treatment boundary based on the determined initial blood perfusion of the target tissue, and
(v) instructions for determining a real-time blood perfusion level within the virtual treatment boundary, and determining a completion percentage of the ablation of the target tissue within the virtual treatment boundary based on the determined real-time blood perfusion level within the virtual treatment boundary, thereby indicating to a user a progress of the ablation of the target tissue.
2. A system as in claim 1 , wherein the ablation element comprises a needle structure extendable from the treatment probe into the target tissue.
3. A system as in claim 2 , wherein the ablation element further comprises a plurality of needles extendable from the needle structure into the target tissue.
4. A system as in claim 1 , wherein the computer readable, non-transient storage medium further comprises instructions for the real-time display to display the real-time blood perfusion level on the real-time image.
5. A system as in claim 1 , wherein the computer readable, non-transient storage medium further comprises instructions for determining whether the determined real-time blood perfusion level within the virtual treatment boundary is below a threshold amount, and indicating to the user to halt ablation of the target tissue in response to the real-time blood perfusion level being below the threshold amount.
6. A system as in claim 5 , wherein the threshold amount is a percentage threshold amount, and wherein the computer readable, non-transient storage medium further comprises instructions for determining an initial blood perfusion level within the virtual treatment boundary, determining a percentage decrease of the determined real-time blood perfusion level within the virtual treatment boundary relative to the determined initial blood perfusion level within the virtual treatment boundary, and indicating to the user to halt ablation of the target tissue in response to the determined percentage decrease of the determined real-time blood perfusion level within the virtual treatment boundary being below the percentage threshold amount.
7. A system as in claim 6 , wherein the percentage threshold amount is 50% or less, 45% or less, 40% or less, 35% or less, 30% or less, 25% or less, 20% or less, 15% or less, 10% or less, or 5% or less of the initial blood perfusion amount of the target tissue.
8. A system as in claim 6 1 , wherein determining the initial blood perfusion of the target tissue comprises determining Doppler ultrasound signals in the target tissue, and wherein determining the real-time blood perfusion level within the virtual target boundary comprises determining a level of Doppler ultrasound signals within the virtual target boundary.
9. A system as in claim 1 , wherein a position of the imaging source is configured to be fixed in relation to the target tissue during the ablation of the target tissue.
10. A system as in claim 9 , wherein the real-time image of the target tissue is generated during the ablation with the position of the imaging source fixed in relation to the target tissue.
11. A system as in claim 1 , wherein the imaging source is configured to be in a fixed position in relation to the ablation element.
12. A system as in claim 1 , wherein the imaging source is configured to be movable relative to the ablation element.
13. A system as in claim 1 , wherein the real-time image of the target tissue comprises at least one ultrasound image of the target tissue.
14. A system as in claim 13 , wherein the at least one ultrasound image comprises one or more of a contrast enhanced ultrasound image, a B-mode ultrasound image, or a Doppler ultrasound image.
15. A system as in claim 14 , wherein the at least one ultrasound image comprises a B-mode ultrasound image and a Doppler ultrasound image overlaid over one another.
16. A system as in claim 1 , wherein the target tissue comprises a fibroid, a uterine fibroid, a fibroid tissue, a tumor, a tissue hyperplasia, or an undesired scar tissue.
17. A system as in claim 1 , wherein the computer readable, non- transient storage medium further comprises instructions for the real-time display to superimpose the real-time virtual treatment boundary over the real-time image.
18. A system as in claim 1 , wherein the computer readable, non-transient storage medium further comprises instructions for the real-time display to display the determined completion percentage of the ablation of the target tissue within the virtual treatment boundary to the user.
19. A system as in claim 1 , wherein the computer readable, non-transient storage medium further comprises instructions for determining a real-time virtual ablation boundary based on a real-time blood perfusion in the target tissue, and alerting the user if the real-time virtual ablation boundary is outside of the virtual treatment boundary.
20. A system as in claim 1 , wherein the computer readable, non- transient storage medium further comprises instructions for modifying the one or more of the size or location of the virtual treatment boundary in response to user manipulation of one or more control elements.