Granted Patent
B2
US 12,194,102 · App. 18/175,020 · Granted Jan 14, 2025
Compositions for enhancing bioavailability of pharmaceuticals, supplements and ingested substances
Inventors:
Andrew R. Lefkowitz (Solon, OH); Sean Farmer (Ft. Lauderdale, FL); Ken Alibek (Solon, OH)
Assignee:
LOCUS SOLUTIONS IPCO, LLC
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Abstract
The present invention relates to compositions and methods for enhancing bioavailability of health-promoting substances, such as pharmaceuticals and nutritional supplements. The subject invention utilizes an adjuvant composition comprising one or more microbial-produced biosurfactants and/or isoforms thereof, to enhance bioavailability of health-promoting substances and to reduce the effective dosage that is required.
Claims (6)
1. A method for administering a health-promoting substance to a tissue in a subject, the method comprising administering, to the subject, an effective amount of a composition comprising a purified sophorolipid, a purified mannosylerythritol lipid (MEL), and said health-promoting substance; wherein said health-promoting substance is an antibiotic or an anti-inflammatory substance; and
wherein said composition is administered to the subject via transdermal or cutaneous administration; and
wherein the health-promoting substance is encapsulated in a nanocapsule formed by the sophorolipid and the MEL.
2. The method of claim 1 , wherein the composition further comprises a pharmaceutically-acceptable carrier.
3. The method of claim 1 , wherein the sophorolipid, the MEL, or both the sophorolipid and the MEL, are present in the composition in critical micelle concentration (CMC).
4. The method of claim 1 , wherein at least 60% by weight of said purified sophorolipid is in an acidic form.
Assignments (5)
SECURITY INTEREST
Recorded Nov 11, 2024
From: LOCUS SOLUTIONS IPCO, LLC
To: U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 069333/0911 →
RELEASE OF SECURITY INTEREST
Recorded Oct 30, 2024
From: U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
To: LOCUS SOLUTIONS IPCO, LLC
Reel/Frame 069273/0361 →
SECURITY INTEREST
Recorded Dec 8, 2023
From: LOCUS SOLUTIONS IPCO, LLC
To: U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS THE COLLATERAL AGENT
Reel/Frame 065836/0868 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 6, 2023
From: LEFKOWITZ, ANDREW R; FARMER, SEAN; ALIBEK, KEN
To: LOCUS IP COMPANY, LLC
Reel/Frame 062889/0577 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 6, 2023
From: LOCUS IP COMPANY, LLC
To: LOCUS SOLUTIONS IPCO, LLC
Reel/Frame 062958/0057 →
Continuity (5)
Continuation
16632626
Provisional Application
62690365
· Jun 27, 2018
Provisional Application
62647974
· Mar 26, 2018
Provisional Application
62537502
· Jul 27, 2017
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