METHODS AND COMPOUNDS FOR INCREASING VIRUCIDAL EFFICACY IN HYDROALCOHOLIC SYSTEMS
A topical sanitizing composition for reducing the concentration of non-enveloped viruses on the skin is provided. The topical sanitizing composition includes one or more pH adjusters, at least one carbomer, and at least about 50 wt. % of one or more C 1-8 alcohols. The sanitizing composition with pH adjuster and carbomer is able to achieve at least a 3.0 log reduction in the concentration of the non-enveloped virus and in some cases passes the EN 14476 standard.
1 . A method of skin treatment, the method comprising:
applying a topical sanitizing composition to a skin surface, wherein the topical sanitizing composition comprises:
at least one pH adjuster;
at least one carbomer; and
greater than 75 wt. % of one or more C 1-8 alcohols,
wherein the weight ratio of pH adjuster/carbomer in the topical sanitizing composition is at least 0.6/1, and
wherein the potentiometric pH of the composition is at least 6.1.
2 . The method of claim 1 , wherein the carbomer comprises a cross-linked polyacrylic acid copolymer.
3 . The method of claim 1 , wherein the pH adjuster comprises one or more of an amine group and an amide group.
4 . The method of claim 1 , wherein the pH adjuster is selected from the group consisting of aminomethyl propanol, triethanolamine, tetrahydroxypropyl ethylenediamine, or combinations thereof.
5 . The method of claim 1 , wherein the weight ratio of pH adjuster/carbomer in the topical sanitizing composition is at least 0.7/1.
6 . The method of claim 1 , wherein the one or more C 1-8 alcohols comprise one or more of methanol, ethanol, propanol, butanol, pentanol, hexanol, and isomers and mixtures thereof.
7 . The method of claim 6 , wherein the one or more C 1-8 alcohols comprise a mixture of ethanol and isopropanol.
8 . The method of claim 1 , wherein the one or more C 1-8 alcohols are present in an amount of at least 77.5 wt. %, based on the total weight of the topical sanitizing composition.
9 . The method of claim 1 , wherein the one or more C 1-8 alcohols are present in an amount of at least 80 wt. %, based on the total weight of the topical sanitizing composition.
10 . The method of claim 1 , wherein the topical sanitizing composition further comprises one or more humectants selected from the group consisting of propylene glycol, hexylene glycol, 1,4-dihydroxyhexane, 1,2,6-hexanetriol, sorbitol, butylene glycol, caprylyl glycol, propanediol, dipropylene glycol, triethylene glycol, glycerin, polyethylene glycol, ethoxydiglycol, polyethylene sorbitol, glycerol caprylate/caprate, or combinations thereof.
11 . The method of claim 10 , wherein the humectant is present in an amount up to 20 wt. %, based on the total weight of the topical sanitizing composition.
12 . The method of claim 1 , wherein the topical sanitizing composition further comprises one or more moisturizing esters selected from the group consisting of cetyl myristate, cetyl myristoleate, diisopropyl sebacate, isopropyl myristate, or combinations thereof.
13 . The method of claim 1 , wherein:
the at least one pH adjuster is present in an amount from 0.01 to 2 wt. %, based on the total weight of the composition; and
the weight ratio of pH adjuster/carbomer in the topical sanitizing composition is at least 1/1.
14 . The method of claim 1 , wherein the at least one carbomer is present in an amount up to 0.5 wt. %, based on the total weight of the composition.
15 . The method of claim 1 , wherein the method achieves a log reduction against one or more non-enveloped viruses of at least 3.0.
16 . The method of claim 1 , wherein the method achieves a log reduction against one or more non-enveloped viruses of at least 4.0.
17 . A method of skin treatment, the method comprising:
applying a topical sanitizing composition to a skin surface, wherein the topical sanitizing composition comprises:
at least one pH adjuster;
an amount up to 0.5 wt. % of at least one carbomer; and
at least 77.5 wt. % of one or more C 1-8 alcohols,
wherein the weight ratio of pH adjuster/carbomer in the topical sanitizing composition is between 0.6/1 and 2.0/1.
18 . The method of claim 17 , wherein the potentiometric pH of the composition is at least 6.1.
19 . The method of claim 17 , wherein the composition comprises at least 80 wt. % of one or more C 1-8 alcohols.
20 . The method of claim 17 , wherein the topical sanitizing composition achieves a log reduction against one or more non-enveloped viruses of at least 4.0.