BUPROPION AS A MODULATOR OF DRUG ACTIVITY
Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.
1 . A method of treating generalized anxiety disorder, comprising administering a combination of dextromethorphan and bupropion to a human being in need thereof.
2 . The method of claim 1 , wherein about 45 mg of the dextromethorphan is orally administered once a day or twice a day.
3 . The method of claim 1 , wherein about 100 mg to about 120 mg of the bupropion is orally administered once a day or twice a day.
4 . The method of claim 1 , wherein about 105 mg of the bupropion is orally administered once a day or twice a day.
5 . The method of claim 1 , wherein the dextromethorphan is orally administered in a dosage form that provides immediate release of the dextromethorphan.
6 . The method of claim 1 , wherein the bupropion is orally administered in a dosage form that provides sustained release of the bupropion.
7 . The method of claim 1 , wherein the bupropion and the dextromethorphan are orally administered together in a single dosage form that is orally administered once a day or twice a day.