Granted Patent B2

US 12,485,256 · App. 18/192,948 · Granted Dec 2, 2025

Inventors: Adel M. Malek (Weston, MA); Carl Heilman (Wayland, MA); David A. Rezac (Westborough, MA); Jack B. Sattell (Boston, MA); Anthony Maiorano (Jamaica Plain, MA)

Assignee: Cerevasc, Inc.

A61M27/006A61M25/04A61B2017/00252A61B2017/22077A61B17/3478A61F2/915A61M25/0147A61M25/065A61M25/09A61M2202/0464A61M2205/32

Abstract

Claims (21)

1 . A system for endovascularly accessing a subarachnoid space (SAS) in a patient, the system comprising:

an expandable anchor configured for being deployed in a dural venous sinus of a patient at a location distal to a curved portion of a sinus wall of the patient;

an elongate guide member coupled to, and extending proximally from, the anchor;

an SAS access catheter comprising a first lumen extending between respective proximal and distal openings in the SAS access catheter, a penetrating element coupled to a distal end of the SAS access catheter; and

a guard at least partially disposed over, and movable relative to, the penetrating element, wherein the guard comprises a tubular guard body having a first guard body lumen or recess configured to receive the penetrating element, a second guard body lumen configured to accommodate passage therethrough of the guide member, and a pull wire having a distal portion attached to the guard body, wherein the pull wire is configured to translate the guard body proximally relative to the SAS access catheter so as to at least partially expose the penetrating element.

2 . The endovascular SAS access system of claim 1 , wherein the pull wire is configured to translate the guard body distally relative to the SAS access catheter so as to at least partially cover the penetrating element.

3 . The endovascular SAS access system of claim 1 , wherein the SAS access catheter further comprises a second lumen extending from the proximal opening to the distal portion of the SAS access catheter, wherein the second lumen is configured to receive the pull wire.

4 . The endovascular SAS access system of claim 1 , wherein a distal portion of the guard body is beveled or tapered.

5 . The endovascular SAS access system of claim 1 , further comprising a first radiopaque marker disposed in or on a wall of the guard body, wherein the guard body is movable relative to the penetrating element so that the first radiopaque marker may be positioned so as to at least partially overlie the penetrating element.

6 . The endovascular SAS access system of claim 5 , wherein the pull wire is coupled to the first radiopaque marker.

7 . The endovascular SAS access system of claim 6 , further comprising a second radiopaque marker disposed in or on the distal portion of the SAS access catheter, wherein the guard body is movable relative to the SAS access catheter so that the first radiopaque marker at least partially overlies the second radiopaque marker.

8 . The endovascular SAS access system of claim 1 , wherein the sinus wall comprises an inferior petrosal sinus of the patient.

9 . The endovascular SAS access system of claim 1 , wherein the dural venous sinus comprises an inferior petrosal sinus or cavernous sinus of the patient.

10 . The endovascular SAS access implantation system claim 1 , further comprising an anchor pusher configured for translating the anchor through an anchor delivery catheter for deployment in the dural venous sinus.

11 . The endovascular SAS access system of claim 10 , wherein the anchor pusher comprises a handle having a lumen extending therethrough; and a hypo tube coupled to the handle, the hypo tube having a hypo tube lumen that is contiguous with or otherwise extends through the handle lumen, the respective handle and hypo tube lumens being configured to receive the guide member, wherein the handle is configured to grasp a portion of the guide member extending proximally through the handle lumen for thereby pushing the guide member, and thus the anchor, distally through the anchor delivery catheter.

12 . The endovascular SAS access system of claim 1 , further comprising a shunt disposed in the first lumen of the delivery catheter.

13 . The endovascular SAS access system of claim 12 , further comprising a pusher member configured to deliver the shunt through the respective first lumen and distal opening of the SAS access catheter.

14 . The endovascular SAS access system of claim 12 , wherein a distal portion of the shunt comprises one or more cerebrospinal fluid (CSF) intake openings disposed in a distal portion of the shunt, the shunt further comprising a valve disposed proximally of the one or more CSF intake openings, and a lumen extending between the one or more CSF intake openings and the valve.

15 . The endovascular SAS access system of claim 14 , wherein the valve is configured to regulate CSF flow through the shunt at a rate of approximately 10 milliliters per hour at a normal differential pressure between the SAS and a venous system of the patient.

16 . The endovascular SAS access system of claim 15 , wherein the valve is a one-way valve configured resist blood backflow through the shunt.

17 . The endovascular SAS access system of claim 1 , wherein the expandable anchor is a self-expanding stent.

Assignments (2)

Continuity (9)

References Cited (340)