IP Library › Granted Patent US 12,298,600
Granted Patent B2
US 12,298,600 · App. 18/196,616 · Granted May 13, 2025

Myopia progression treatment

Inventor: Leonard Zheleznyak (Pittsford, NY)
Assignee: Clerio Vision, Inc.
G02C7/027G02C7/022G02C7/044G02C2202/24
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Quick Facts
Patent No.
US 12,298,600
App. No.
18/196,616
Granted
May 13, 2025
Kind
B2
Abstract

A ophthalmic lens for inhibiting progression of myopia includes a central zone and an annular zone. The annular zone includes subsurface optical elements formed via laser-induced changes in refractive index of a material forming the annular zone. The subsurface optical elements are configured to modify distribution of light to the peripheral retina of a user so as to inhibit progression of myopia.

Claims (35)

1. An ophthalmic lens comprising:

a central zone; and

an annular zone comprising subsurface optical elements formed via laser-induced changes in refractive index in targeted subsurface sub-volumes of the annular zone via laser beam pulses focused onto the targeted subsurface sub-volumes, wherein the subsurface optical elements are configured to modify distribution of light to a peripheral retina of a user so as to inhibit progression of myopia, and wherein the subsurface optical elements are arranged in one or more subsurface layers of the annular zone.

2. The ophthalmic lens of claim 1 , wherein the subsurface optical elements are configured to reduce asymmetry of a radial versus azimuthal contrast in the peripheral retina of the user.

3. The ophthalmic lens of claim 1 , wherein the subsurface optical elements are configured to reduce hyperopia in the peripheral retina of the user.

4. The ophthalmic lens of claim 1 , wherein the subsurface optical elements are configured to increase depth of focus in the peripheral retina of the user.

5. The ophthalmic lens of claim 1 , wherein the subsurface optical elements are configured to decrease depth of focus in the peripheral retina of the user.

6. The ophthalmic lens of claim 1 , wherein the subsurface optical elements are configured to accomplish two or more of:

reduce asymmetry of a radial versus azimuthal contrast in the peripheral retina of the user;

reduce hyperopia in the peripheral retina of the user; and

increase depth of focus in the peripheral retina of the user.

7. The ophthalmic lens of claim 1 , wherein the subsurface optical elements are configured to accomplish two or more of:

reduce asymmetry of a radial versus azimuthal contrast in the peripheral retina of the user;

reduce hyperopia in the peripheral retina of the user; and

decrease depth of focus in the peripheral retina of the user.

8. The ophthalmic lens of claim 1 , wherein the subsurface optical elements are configured to accomplish two or more of:

increase asymmetry of a radial versus azimuthal contrast in the peripheral retina of the user;

reduce hyperopia in the peripheral retina of the user; and

increase depth of focus in the peripheral retina of the user.

9. The ophthalmic lens of claim 1 , wherein the subsurface optical elements are configured to accomplish two or more of:

increase asymmetry of a radial versus azimuthal contrast in the peripheral retina of the user;

reduce hyperopia in the peripheral retina of the user; and

decrease depth of focus in the peripheral retina of the user.

10. The ophthalmic lens of claim 1 , wherein the annular zone comprises two or more annular portions, and wherein the subsurface optical elements in each of the two or more annular portions are configured to accomplish one or both of:

reduce asymmetry of a radial versus azimuthal contrast in the peripheral retina of the user; and/or

reduce hyperopia in the peripheral retina of the user.

11. The ophthalmic lens of claim 10 , wherein the subsurface optical elements in each of the two or more annular portions are configured to increase depth of focus in the peripheral retina of the user.

12. The ophthalmic lens of claim 10 , wherein the subsurface optical elements in each of the two or more annular portions are configured to decrease depth of focus in the peripheral retina of the user.

13. The ophthalmic lens of claim 1 , configured as a contact lens.

14. The ophthalmic lens of claim 1 , configured as a spectacle lens.

15. The ophthalmic lens of claim 1 , configured as a cornea.

16. The ophthalmic lens of claim 1 , configured as a native lens of an eye.

17. The ophthalmic lens of claim 1 , configured as an intraocular lens.

18. The ophthalmic lens of claim 1 , wherein at least one of the one or more subsurface layers of the subsurface optical elements has a phase-wrapped configuration.

19. The ophthalmic lens of claim 18 , wherein the phase-wrapped configuration has a fractional number phase-wrapped configuration.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 26, 2023
From: ZHELEZNYAK, LEONARD
To: CLERIO VISION, INC.
Reel/Frame 064062/0024 →
Continuity (3)
Continuation 16928505 · Jul 14, 2020
Provisional Application 62876126 · Jul 19, 2019
Related Publication 20230280600A1 · Sep 7, 2023
References Cited (125)
US 5849006A · Frey et al. · 1998 [cited by applicant]
US 6261220B1 · Frey et al. · 2001 [cited by applicant]
US 6271914B1 · Frey et al. · 2001 [cited by applicant]
US 6720221B1 · Ahn et al. · 2004 [cited by applicant]
US 6830332B2 · Piers et al. · 2004 [cited by applicant]
US 7001374B2 · Peyman · 2006 [cited by examiner]
US 7677725B2 · Piers et al. · 2010 [cited by applicant]
US 7789910B2 · Knox et al. · 2010 [cited by applicant]
US 8337553B2 · Knox et al. · 2012 [cited by applicant]
US 8512320B1 · Knox et al. · 2013 [cited by applicant]
US 8617147B2 · Knox et al. · 2013 [cited by applicant]
US 8901190B2 · Smith et al. · 2014 [cited by applicant]
US 8932352B2 · Knox et al. · 2015 [cited by applicant]
US 9060847B2 · Smith et al. · 2015 [cited by applicant]
US 9144491B2 · Knox et al. · 2015 [cited by applicant]
US 9492323B2 · Knox et al. · 2016 [cited by applicant]
US 9545340B1 · Knox et al. · 2017 [cited by applicant]
US 9622912B2 · Knox et al. · 2017 [cited by applicant]
US 9939558B2 · Knox et al. · 2018 [cited by applicant]
US 10226381B2 · Knox et al. · 2019 [cited by applicant]
US 10932901B2 · Zheleznyak et al. · 2021 [cited by applicant]
US 20050187622A1 · Sandstedt et al. · 2005 [cited by applicant]
US 20080001320A1 · Knox et al. · 2008 [cited by applicant]
US 20110037944A1 · Varnas · 2011 [cited by applicant]
US 20120081661A1 · Yamakaji · 2012 [cited by applicant]
US 20120150166A1 · Neev · 2012 [cited by examiner]
US 20120310223A1 · Knox et al. · 2012 [cited by applicant]
US 20130010255A1 · Holden et al. · 2013 [cited by applicant]
US 20130178934A1 · Knox et al. · 2013 [cited by applicant]
US 20130226162A1 · Knox et al. · 2013 [cited by applicant]
US 20130278888A1 · Bakaraju et al. · 2013 [cited by applicant]
US 20140104563A1 · Bakaraju · 2014 [cited by examiner]
US 20140268029A1 · Pugh et al. · 2014 [cited by applicant]
US 20150277145A1 · Bakaraju et al. · 2015 [cited by applicant]
US 20150277150A1 · Granger et al. · 2015 [cited by applicant]
US 20160144580A1 · Knox et al. · 2016 [cited by applicant]
US 20170035613A1 · Knox et al. · 2017 [cited by applicant]
US 20170119581A1 · Gray et al. · 2017 [cited by applicant]
US 20170146820A1 · Brennan et al. · 2017 [cited by applicant]
US 20170176772A1 · Bakaraju et al. · 2017 [cited by applicant]
US 20170181846A1 · Knox et al. · 2017 [cited by applicant]
US 20180021172A1 · Zheleznyak et al. · 2018 [cited by applicant]
US 20180132996A1 · Tiwari et al. · 2018 [cited by applicant]
US 20180173009A1 · Knox et al. · 2018 [cited by applicant]
US 20180206979A1 · Knox et al. · 2018 [cited by applicant]
US 20180231696A1 · Knox et al. · 2018 [cited by applicant]
US 20180243082A1 · Zheleznyak · 2018 [cited by examiner]
US 20180373060A1 · Knox et al. · 2018 [cited by applicant]
US 20190046357A1 · Knox et al. · 2019 [cited by applicant]
US 20190072786A1 · Krause et al. · 2019 [cited by applicant]
US 20190343683A1 · Zheleznyak et al. · 2019 [cited by applicant]
US 20200054485A1 · Knox · 2020 [cited by applicant]
US 20210018762A1 · Zheleznyak · 2021 [cited by applicant]
US 20210356767A1 · Kubota et al. · 2021 [cited by applicant]
CN 107861262A · 2018 [cited by applicant]
FR 2989179A3 · 2013 [cited by applicant]
WO 2008002796A2 · 2008 [cited by applicant]
WO 2009143054A2 · 2009 [cited by applicant]
WO 2012166696A1 · 2012 [cited by applicant]
WO 2015006274A1 · 2015 [cited by applicant]
WO WO2016070243A1 · 2016 [cited by examiner]
WO 2016196200A1 · 2016 [cited by applicant]
WO 2017106321A1 · 2017 [cited by applicant]
WO 2018152595A1 · 2018 [cited by applicant]
WO 2018182946A1 · 2018 [cited by applicant]
WO 2019010345A1 · 2019 [cited by applicant]
WO 2019147952A1 · 2019 [cited by applicant]
WO 2020102514A1 · 2020 [cited by applicant]
WO 2021108585A1 · 2021 [cited by applicant]
Aguila-Carrasco et al., “Aberrations and Accommodation”, Clinical and Experimental Optometry, vol. 103, Jul. 8, 2019, pp. 95-103. [cited by applicant]
Atchison et al., “Chromatic Dispersions of the Ocular Media of Human Eyes”, Journal of the Optical Society of America A, vol. 22, No. 1, Jan. 2005, pp. 29-37. [cited by applicant]
Banks et al., “ChromaBlur: Rendering Natural Chromatic Aberration Drives Accommodation Effectively”, Journal of Vision, vol. 18, No. 10, Abstract only, Sep. 2018, 2 pp. [cited by applicant]
Banks et al., “Peripheral Spatial Vision: Limits Imposed by Optics, Photoreceptors, and Receptor Pooling”, Journal of the Optical Society of America, vol. 8, No. 11, Nov. 1991, pp. 1775-1787. [cited by applicant]
Bao et al., “One-year myopia control efficacy of spectacle lenses with aspherical lenslets”, Br J Ophthalmol, 106, 2022, pp. 1171-1176. [cited by applicant]
Benedi-Garcia et al., “Vision is Protected Against Blue Defocus”, Scientific Reports, vol. 11, Jan. 11, 2021, pp. 1-9. [cited by applicant]
Bloomfield , “Orientation-Sensitive Amacrine and Ganglion Cells in the Rabbit Retina”, Journal of Neurophysiology, vol. 71, No. 5, May 1994, pp. 1672-1691. [cited by applicant]
Bloomfield , “Two Types of Orientation-Sensitive Responses of Amacrine Cells in the Mammalian Retina”, Nature, vol. 350, Mar. 28, 1991, pp. 347-350. [cited by applicant]
Chen et al., “Accommodation with Higher-order Monochromatic Aberrations Corrected with Adaptive Optics”, Journal of the Optical Society of America A, vol. 23, No. 1, Jan. 2006, pp. 1-8. [cited by applicant]
Cholewiak et al., “ChromaBlur: Rendering Chromatic Eye Aberration Improves Accommodation and Realism”, ACM Transactions on Graphics, vol. 36, No. 6, Nov. 2017, pp. 1-12. [cited by applicant]
Cholewiak et al., “ChromaBlur: Rendering Chromatic Eye Aberration Improves Accommodation and Realism in HMDs”, ACM Transactions on Graphics, vol. 36, No. 6, Article 210, Nov. 2017, pp. 210:1 thru 210:12. [cited by applicant]
Cholewiak et al., “Creating Correct Blur and Its Effect on Accommodation”, Journal of Vision, vol. 18, No. 9, Sep. 4, 2018, pp. 1-29. [cited by applicant]
Fernandez et al., “Adaptation to the Eye's Chromatic Aberration Measured with an Adaptive Optics Visual Simulator”, Optics Express, vol. 28, No. 25, Nov. 30, 2020, pp. 37450-37458. [cited by applicant]
Flitcroft et al., “IMI—Defining and Classifying Myopia: A Proposed Set of Standards for Clinical and Epidemiologic Studies”, Investigative Ophthalmology & Visual Science, vol. 60, No. 3, Feb. 2019, pp. M20-M30. [cited by applicant]
Gantes-Nunez et al., “Optical characterisation of two novel myopia control spectacle lenses”, Ophthalmic Physiol Opt., 43, 2023, pp. 388-401. [cited by applicant]
Gawne et al., “An Opponent Dual-detector Spectral Drive Model of Emmetropization”, Vision Research, vol. 173, Aug. 2020, pp. 7-20. [cited by applicant]
Gawne et al., “Chromatically Simulated Myopic Blur Counteracts a Myopiagenic Environment”, Experimental Eye Research, vol. 222, Sep. 2022, pp. 1-6. [cited by applicant]
Gawne et al., “How Chromatic Cues can Guide Human Eye Growth to Achieve Good Focus”, Journal of Vision, vol. 21, No. 5, May 13, 2021, pp. 1-11. [cited by applicant]
Gifford et al., “IMI—Clinical Management Guidelines Report”, IOVS, Special Issue, vol. 60, No. 3, pp. M184-M203. [cited by applicant]
Graef et al., “Control of Accommodation by Longitudinal Chromatic Aberration and Blue Cones”, Journal of Vision, vol. 12, Jan. 18, 2012, pp. 1-12. [cited by applicant]
Hiraoka et al., “Relationships Between Higher-order Wavefront Aberrations and Natural Progression of Myopia in Schoolchildren”, Scientific Reports, vol. 7, Article No. 7876, Aug. 11, 2017, 9 Pages. [cited by applicant]
Huang et al., “Efficacy Comparison of 16 Interventions for Myopia Control in Children”, America Academy of Ophthalmology, vol. 123, No. 4, Apr. 2016, pp. 697-708. [cited by applicant]
Jaskulski et al., “The Effect of Longitudinal Chromatic Aberration on the Lag of Accommodation and Depth of Field”, Ophthalmic & Physiological Optics, vol. 36, No. 6, Nov. 2016, pp. 657-663. [cited by applicant]
Jiang et al., “Measuring and Compensating for Ocular Longitudinal Chromatic Aberration”, Optica, vol. 6, No. 8, Aug. 2019, pp. 981-990. [cited by applicant]
Lam et al., “Defocus Incorporated Multiple Segments (DIMS) spectacle lenses slow myopia progression: a 2-year randomised clinical trial”, Br J Ophthalmol, 104, 2020, pp. 363-368. [cited by applicant]
Leung et al., “Meridional Anisotropy of Foveal and Peripheral Resolution Acuity in Adults with Emmetropia, Myopia, and Astigmatism”, Investigative Ophthalmology & Visual Science, vol. 62, No. 10, Aug. 2021, pp. 1-6. [cited by applicant]
Levick et al., “Analysis of Orientation Bias in Cat Retina”, The Journal of Physiology, vol. 329, Aug. 1982, pp. 243-261. [cited by applicant]
Li et al., “Studies Using Concentric Ring Bifocal and Peripheral Add Multifocal Contact Lenses to Slow Myopia Progression in School-Aged Children: A Meta-Analysis”, Ophthalmic & Physiological Optics, vol. 37, No. 1, Jan… [cited by applicant]
Lopez-Gil et al., “New Intraocular Lens for Achromatizing the Human Eye”, Journal of Cataract and Refractive Surgery, vol. 33, No. 7, Aug. 2007, pp. 1296-1302. [cited by applicant]
Marcos et al., “A New Approach to the Study of Ocular Chromatic Aberrations”, Vision Research, vol. 39, No. 26, Dec. 1999, pp. 4309-4323. [cited by applicant]
Martinez et al., “Chromatic Aberration Control with Liquid Crystal Spatial Phase Modulators”, Optics Express, vol. 25, No. 9, May 1, 2017, pp. 9793-9801. [cited by applicant]
Mclellan et al., “Imperfect Optics May be the Eye's Defence Against Chromatic Blur”, Nature, vol. 417, May 9, 2002, pp. 174-176. [cited by applicant]
Moreno et al., “Modulation Light Efficiency of Diffractive Lenses Displayed in a Restricted Phase-Mostly Modulation Display”, Applied Optics, vol. 43, No. 34, Dec. 1, 2004, pp. 6278-6284. [cited by applicant]
Passaglia et al., “Orientation Sensitivity of Ganglion Cells in Primate Retina”, Vision Research, vol. 42, Mar. 2002, pp. 683-694. [cited by applicant]
Powell , “Lenses for Correcting Chromatic Aberration of the Eye”, Applied Optics, vol. 20, No. 24, Dec. 15, 1981, pp. 4152-4155. [cited by applicant]
Resnikoff et al., “Myopia—A 21st Century Public Health Issue”, Investigative Ophthalmology & Visual Science, vol. 60, No. 3, Feb. 2019, pp. Mi-Mii. [cited by applicant]
Rohrer et al., “Longitudinal Chromatic Aberration and Emmetropization: Results from the Chicken Eye”, Journal of Physiology, vol. 449, Apr. 1992, pp. 363-376. [cited by applicant]
Romashchenko et al., “Peripheral refraction and higher order aberrations”, Clinical and Experimental Optometry 103.1, Jan. 2020, pp. 86-94. [cited by applicant]
Rucker et al., “Chick Eyes Compensate for Chromatic Simulations of Hyperopic and Myopic Defocus: Evidence that the Eye Uses Longitudinal Chromatic Aberration to Guide Eye-growth”, Vision Research, vol. 49, No. 14, Jul. … [cited by applicant]
Rucker et al., “Signals for Defocus Arise from Longitudinal Chromatic Aberration in Chick”, Experimental Eye Research, vol. 198, Sep. 2020, 10 pages. [cited by applicant]
Rucker , “The Role of Luminance and Chromatic Cues in Emmetropisation”, Ophthalmic & Physiological Optics, vol. 33, No. 3, May 2013, pp. 196-214. [cited by applicant]
Savage et al., “First Demonstration of Ocular Refractive Change Using Blue-IRIS in Live Cats”, Investigative Ophthalmology & Visual Science, vol. 55, No. 7, Jul. 1, 2014, pp. 4603-4612. [cited by applicant]
Schall et al., “Retinal Ganglion Cell Dendritic Fields in Old-World Monkeys are Oriented Radially”, Brain Research, vol. 368, Mar. 1986, pp. 18-23. [cited by applicant]
Seidemann et al., “Effects of Longitudinal Chromatic Aberration on Accommodation and Emmetropization”, Vision Research, vol. 42, No. 21, Sep. 2002, pp. 2409-2417. [cited by applicant]
Si et al., “Orthokeratology for Myopia Control: A Meta-Analysis”, Optometry and Vision Science, vol. 92, No. 3, Mar. 2015, pp. 252-257. [cited by applicant]
Smith et al., “Peripheral Vision Can Influence Eye Growth and Refractive Development in Infant Monkeys”, Investigative Ophthalmology & Visual Science, vol. 46, No. 11, Nov. 2005, 16 Pages. [cited by applicant]
Suchkov et al., “Impact of Longitudinal Chromatic Aberration on Through-focus Visual Acuity”, Optics Express, vol. 27, No. 24, Nov. 25, 2019, pp. 35935-35947. [cited by applicant]
Swiatczak et al., “Myopia: Why the Retina Stops Inhibiting Eye Growth”, Scientific Reports, vol. 12, Dec. 15, 2022, pp. 1-9. [cited by applicant]
Tedja et al., “IMI—Myopia Genetics Report”, Investigative Ophthalmology & Visual Science, vol. 60, No. 3, Feb. 2019, pp. M89-M105. [cited by applicant]
Troilo et al., “IMI—Report on Experimental Models of Emmetropization And Myopia”, Investigative Ophthalmology & Visual Science, vol. 60, No. 3, Feb. 2019, pp. M31-M88. [cited by applicant]
Weeber et al., “Theoretical Performance of Intraocular Lenses Correcting Both Spherical and Chromatic Aberration”, Journal of Refractive Surgery, vol. 28, No. 1, Jan. 2012, pp. 48-52. [cited by applicant]
Wildsoet et al., “IMI—Interventions for Controlling Myopia Onset and Progression Report”, Investigative Ophthalmology & Visual Science, vol. 60, No. 3, Feb. 2019, pp. M106-M131. [cited by applicant]
Wolffsohn et al., “IMI—Clinical Myopia Control Trials and Instrumentation Report”, Investigative Ophthalmology & Visual Science, vol. 60, No. 3, Feb. 2019, pp. M132-M160. [cited by applicant]
Wolffsohn et al., “IMI—Myopia Control Reports Overview and Introduction”, Investigative Ophthalmology & Visual Science, vol. 60, No. 3, Feb. 2019, pp. M1-M19. [cited by applicant]
Xu et al., “Noninvasive Intratissue Refractive Index Shaping (IRIS) of the Cornea with Blue Femtosecond Laser Light”, Investigative Ophthalmology & Visual Science, vol. 52, No. 11, Oct. 17, 2011, pp. 8148-8155. [cited by applicant]
Zheleznyak et al., “Optical and Neural Anisotropy in Peripheral Vision”, Journal of Vision, vol. 16, No. 5, Mar. 2016, pp. 1-11. [cited by applicant]
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