IP Library › Granted Patent US 12,471,977
Granted Patent B2
US 12,471,977 · App. 18/196,778 · Granted Nov 18, 2025

Secure cryosurgical treatment system

Inventors: Corydon A. Hinton (Oakland, CA); Kyler Mikhail Connelly (Castro Valley, CA); Bijy Zachariah (Fremont, CA); Jesse Rosen (Albany, CA)
Assignee: Pacira CryoTech, Inc.
A61B18/02A61B2017/00199A61B2017/0023A61B2017/00482A61B2018/00041A61B2018/00714A61B2018/00744A61B2018/00791A61B2018/00922A61B2018/00988A61B2018/0262A61B2018/0268A61B2018/0293A61B34/25A61B2090/0803A61B2090/0814A61B90/90
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,471,977
App. No.
18/196,778
Granted
Nov 18, 2025
Kind
B2
Abstract

A method for cryogenically treating tissue. A connection is detected between a probe having a disposable secure processor (DSP) to a handpiece having a master control unit (MCU) and a handpiece secure processor (HSP), the probe having at least one cryogenic treatment applicator. The probe is fluidly coupled to a closed coolant supply system within the handpiece via the connection. An authentication process is initiated between the DSP and the HSP using the MCU. As a result of the authentication process, one of at least two predetermined results is determined, the at least two predetermined results being that the probe is authorized and non-authorized.

Claims (28)

1 . A system comprising:

a cryogenic handpiece operable by a microprocessor control unit; and

a probe removably coupled to the handpiece, configured to receive coolant from the handpiece, and having a disposable secure processor communicatively coupled to the microprocessor control unit;

wherein the disposable secure processor comprises operating instructions for execution by the microprocessor control unit to control coolant to the probe.

2 . The system of claim 1 , wherein the cryogenic handpiece is configured to provide coolant from a coolant supply system to the probe, wherein the coolant supply system comprises a cannister disposed within the cryogenic handpiece.

3 . The system of claim 2 , further comprising a supply valve disposed between the cannister and the probe to regulate the coolant to the probe.

4 . The system of claim 3 , wherein the microprocessor control unit is configured to actuate the supply valve, wherein the operating instructions comprise a protocol for timing opening and closing of the supply valve.

5 . The system of claim 3 , wherein the microprocessor control unit is configured to provide control signals to the supply valve to implement an authorized treatment algorithm.

6 . The system of claim 5 , wherein the authorized treatment algorithm includes control of time, temperature, cycling, pulsing, or ramp rates for cooling or thawing.

7 . The system of claim 3 , wherein the supply valve comprises an electrically actuated solenoid valve or a motor actuated valve.

8 . The system of claim 1 , wherein the microprocessor control unit is configured to control coolant to the probe by regulating a treatment time, coolant flow rate, temperature, or a rate of temperature change.

9 . The system of claim 1 , wherein the cryogenic handpiece further comprises a handpiece secure processor.

10 . The system of claim 9 , wherein the microprocessor control unit is configured to:

detect connection of the probe to the cryogenic handpiece;

initiate an authentication process between the disposable secure processor and the handpiece secure processor using the microprocessor control unit; and

as a result of the authentication process, determine one of at least two predetermined results, the at least two predetermined results comprising that the probe is authorized and non-authorized.

11 . The system of claim 1 , wherein the microprocessor control unit is configured to:

request the disposable secure processor to determine expiry; and

based on the reply to this request, determining one of: that the probe is expired and non-expired.

12 . The system of claim 11 , wherein, as a result that the probe is determined to be non-expired, the microprocessor control unit retrieves data containing procedural parameters for operating the probe from the disposable secure processor.

13 . The system of claim 12 , wherein the data includes cooling cycle time parameters.

14 . The system of claim 11 , wherein determining one of: that the probe is expired and non-expired comprises sending a request to the disposable secure processor to check the allowed remaining uses of the probe.

15 . The system of claim 14 , wherein after receiving the request, the disposable secure processor determines the remaining allowable uses of the probe and provides the microprocessor control unit with one of: an indication that the probe has no remaining uses available and an indication that the probe can be used.

16 . The system of claim 15 , wherein the disposable secure processor provides the microprocessor control unit with the indication that the probe can be used and updates a use counter of the probe.

17 . The system of claim 1 , wherein the probe further comprises a heater and the operating instructions include heater control parameters.

18 . The system of claim 1 , wherein the probe further comprises at least one cryogenic treatment applicator.

19 . The system of claim 18 , wherein the at least one cryogenic treatment applicator comprises a sharpened or blunted needle.

20 . The system of claim 1 , wherein the cryogenic handpiece further comprises a cryogenic cooling fluid supply, a supply valve, and an electrical power source disposed within the cryogenic handpiece.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 7, 2023
From: HINTON, CORYDON A.; CONNELLY, KYLER MIKHAIL; ZACHARIAH, BIJY; ROSEN, JESSE
To: MYOSCIENCE, INC.
Reel/Frame 063887/0453 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 7, 2023
From: MYOSCIENCE, INC.
To: PACIRA CRYOTECH, INC.
Reel/Frame 063909/0434 →
Continuity (5)
Continuation 17091366 · Nov 6, 2020
Continuation 16168551 · Oct 23, 2018
Continuation 14534120 · Nov 5, 2014
Provisional Application 61900345 · Nov 5, 2013
Related Publication 20230277232A1 · Sep 7, 2023
References Cited (303)
US 2319542A · Hall · 1943 [cited by applicant]
US 2672032A · Towse · 1954 [cited by applicant]
US 3266492A · Steinberg · 1966 [cited by applicant]
US 3289424A · Shepherd · 1966 [cited by applicant]
US 3343544A · Dunn et al. · 1967 [cited by applicant]
US 3351063A · Malaker et al. · 1967 [cited by applicant]
US 3439680A · Thomas, Jr. · 1969 [cited by applicant]
US 3483869A · Hayhurst · 1969 [cited by applicant]
US 3507283A · Thomas, Jr. · 1970 [cited by applicant]
US 3532094A · Stahl · 1970 [cited by applicant]
US 3664344A · Bryne · 1972 [cited by applicant]
US 3702114A · Zacarian · 1972 [cited by applicant]
US 3795245A · Allen, Jr. et al. · 1974 [cited by applicant]
US 3814095A · Lubens · 1974 [cited by applicant]
US 3830239A · Stumpf et al. · 1974 [cited by applicant]
US 3886945A · Stumpf et al. · 1975 [cited by applicant]
US 3889681A · Waller et al. · 1975 [cited by applicant]
US 3951152A · Crandell et al. · 1976 [cited by applicant]
US 3993075A · Lisenbee et al. · 1976 [cited by applicant]
US 4140109A · Savic et al. · 1979 [cited by applicant]
US 4207897A · Lloyd et al. · 1980 [cited by applicant]
US 4236518A · Floyd · 1980 [cited by applicant]
US 4306568A · Torre · 1981 [cited by applicant]
US 4376376A · Gregory · 1983 [cited by applicant]
US 4404862A · Harris, Sr. · 1983 [cited by applicant]
US 4524771A · McGregor et al. · 1985 [cited by applicant]
US 4758217A · Gueret · 1988 [cited by applicant]
US 4802475A · Weshahy · 1989 [cited by applicant]
US 4946460A · Merry et al. · 1990 [cited by applicant]
US 5059197A · Urie et al. · 1991 [cited by applicant]
US 5200170A · McDow · 1993 [cited by applicant]
US 5294325A · Liu · 1994 [cited by applicant]
US 5334181A · Rubinsky et al. · 1994 [cited by applicant]
US 5520681A · Fuller et al. · 1996 [cited by applicant]
US 5571147A · Sluijter et al. · 1996 [cited by applicant]
US 5647868A · Chinn · 1997 [cited by applicant]
US 5747777A · Matsuoka · 1998 [cited by applicant]
US 5755753A · Knowlton · 1998 [cited by applicant]
US 5814040A · Nelson et al. · 1998 [cited by applicant]
US 5860970A · Goddard et al. · 1999 [cited by applicant]
US 5879378A · Usui · 1999 [cited by applicant]
US 5899897A · Rabin et al. · 1999 [cited by applicant]
US 5916212A · Baust et al. · 1999 [cited by applicant]
US 5976505A · Henderson · 1999 [cited by applicant]
US 6003539A · Yoshihara · 1999 [cited by applicant]
US 6032675A · Rubinsky · 2000 [cited by applicant]
US 6039730A · Rabin et al. · 2000 [cited by applicant]
US 6041787A · Rubinsky · 2000 [cited by applicant]
US 6139545A · Utley et al. · 2000 [cited by applicant]
US 6141985A · Cluzeau et al. · 2000 [cited by applicant]
US 6142991A · Schatzberger · 2000 [cited by applicant]
US 6182666B1 · Dobak, III · 2001 [cited by applicant]
US 6196839B1 · Ross · 2001 [cited by applicant]
US 6238386B1 · Muller et al. · 2001 [cited by applicant]
US 6277099B1 · Strowe et al. · 2001 [cited by applicant]
US 6277116B1 · Utely et al. · 2001 [cited by applicant]
US 6363730B1 · Thomas et al. · 2002 [cited by applicant]
US 6371943B1 · Racz et al. · 2002 [cited by applicant]
US 6432102B2 · Joye et al. · 2002 [cited by applicant]
US 6494844B1 · Van Bladel et al. · 2002 [cited by applicant]
US 6503246B1 · Har-Shai et al. · 2003 [cited by applicant]
US 6506796B1 · Fesus et al. · 2003 [cited by applicant]
US 6546935B2 · Hooven · 2003 [cited by applicant]
US 6551309B1 · LePivert · 2003 [cited by applicant]
US 6562030B1 · Abboud et al. · 2003 [cited by applicant]
US 6629951B2 · Laufer et al. · 2003 [cited by applicant]
US 6648880B2 · Chauvet et al. · 2003 [cited by applicant]
US 6669688B2 · Svaasand et al. · 2003 [cited by applicant]
US 6672095B1 · Luo · 2004 [cited by applicant]
US 6682501B1 · Nelson et al. · 2004 [cited by applicant]
US 6706037B2 · Zvuloni et al. · 2004 [cited by applicant]
US 6723092B2 · Brown et al. · 2004 [cited by applicant]
US 6749624B2 · Knowlton · 2004 [cited by applicant]
US 6761715B2 · Carroll · 2004 [cited by applicant]
US 6764493B1 · Weber et al. · 2004 [cited by applicant]
US 6786901B2 · Joye et al. · 2004 [cited by applicant]
US 6786902B1 · Rabin et al. · 2004 [cited by applicant]
US 6789545B2 · Littrup et al. · 2004 [cited by applicant]
US 6840935B2 · Lee · 2005 [cited by applicant]
US 6858025B2 · Maurice · 2005 [cited by applicant]
US 6902554B2 · Huttner · 2005 [cited by applicant]
US 6905492B2 · Zvuloni et al. · 2005 [cited by applicant]
US 6960208B2 · Bourne et al. · 2005 [cited by applicant]
US 7001400B1 · Modesitt et al. · 2006 [cited by applicant]
US 7081111B2 · Svaasand et al. · 2006 [cited by applicant]
US 7081112B2 · Joye et al. · 2006 [cited by applicant]
US 7083612B2 · Littrup et al. · 2006 [cited by applicant]
US 7195616B2 · Diller et al. · 2007 [cited by applicant]
US 7204833B1 · Osorio et al. · 2007 [cited by applicant]
US 7217939B2 · Johansson et al. · 2007 [cited by applicant]
US 7250046B1 · Fallat · 2007 [cited by applicant]
US 7311672B2 · Van Bladel et al. · 2007 [cited by applicant]
US 7367341B2 · Anderson et al. · 2008 [cited by applicant]
US 7402140B2 · Spero et al. · 2008 [cited by applicant]
US 7422586B2 · Morris et al. · 2008 [cited by applicant]
US 7578819B2 · Bleich et al. · 2009 [cited by applicant]
US 7641679B2 · Joye et al. · 2010 [cited by applicant]
US 7713266B2 · Elkins et al. · 2010 [cited by applicant]
US 7850683B2 · Elkins et al. · 2010 [cited by applicant]
US 7862558B2 · Elkins et al. · 2011 [cited by applicant]
US 7998137B2 · Elkins et al. · 2011 [cited by applicant]
US 8298216B2 · Burger et al. · 2012 [cited by applicant]
US 8409185B2 · Burger et al. · 2013 [cited by applicant]
US 8461108B2 · Hsu et al. · 2013 [cited by applicant]
US 8715275B2 · Burger et al. · 2014 [cited by applicant]
US 9039688B2 · Palmer, III et al. · 2015 [cited by applicant]
US 9066712B2 · Fourkas et al. · 2015 [cited by applicant]
US 9072498B2 · Elkins et al. · 2015 [cited by applicant]
US 9241753B2 · Fourkas et al. · 2016 [cited by applicant]
US 9254162B2 · Burger et al. · 2016 [cited by applicant]
US 9295512B2 · Allison et al. · 2016 [cited by applicant]
US 9314290B2 · Fourkas et al. · 2016 [cited by applicant]
US 9345526B2 · Elkins et al. · 2016 [cited by applicant]
US 9668800B2 · Karnik et al. · 2017 [cited by applicant]
US 10016229B2 · Carnell et al. · 2018 [cited by applicant]
US 10085881B2 · Karnik et al. · 2018 [cited by applicant]
US 10130409B2 · Hinton et al. · 2018 [cited by applicant]
US 10314739B2 · Allison et al. · 2019 [cited by applicant]
US 10596030B2 · Karnik et al. · 2020 [cited by applicant]
US 10864033B2 · Hinton et al. · 2020 [cited by applicant]
US 10888366B2 · Allison · 2021 [cited by applicant]
US 11690661B2 · Hinton et al. · 2023 [cited by applicant]
US 20020010460A1 · Joye et al. · 2002 [cited by applicant]
US 20020013602A1 · Huttner · 2002 [cited by applicant]
US 20020045434A1 · Masoian et al. · 2002 [cited by applicant]
US 20020049436A1 · Zvuloni et al. · 2002 [cited by applicant]
US 20020068929A1 · Zvuloni · 2002 [cited by applicant]
US 20020120260A1 · Morris et al. · 2002 [cited by applicant]
US 20020120261A1 · Morris et al. · 2002 [cited by applicant]
US 20020120263A1 · Brown et al. · 2002 [cited by applicant]
US 20020128638A1 · Chauvet et al. · 2002 [cited by applicant]
US 20020156469A1 · Yon et al. · 2002 [cited by applicant]
US 20020183731A1 · Holland et al. · 2002 [cited by applicant]
US 20020193778A1 · Alchas et al. · 2002 [cited by applicant]
US 20030036752A1 · Joye et al. · 2003 [cited by applicant]
US 20030109912A1 · Joye et al. · 2003 [cited by applicant]
US 20030130575A1 · Desai · 2003 [cited by applicant]
US 20030181896A1 · Zvuloni et al. · 2003 [cited by applicant]
US 20030195436A1 · Van Bladel et al. · 2003 [cited by applicant]
US 20030220635A1 · Knowlton et al. · 2003 [cited by applicant]
US 20030220674A1 · Anderson et al. · 2003 [cited by applicant]
US 20040024391A1 · Cytron et al. · 2004 [cited by applicant]
US 20040082943A1 · Littrup et al. · 2004 [cited by applicant]
US 20040092875A1 · Kochamba · 2004 [cited by applicant]
US 20040122482A1 · Tung et al. · 2004 [cited by applicant]
US 20040143252A1 · Hurst · 2004 [cited by applicant]
US 20040162551A1 · Brown et al. · 2004 [cited by applicant]
US 20040167505A1 · Joye et al. · 2004 [cited by applicant]
US 20040191229A1 · Link, Jr. et al. · 2004 [cited by applicant]
US 20040204705A1 · Lafontaine · 2004 [cited by applicant]
US 20040210212A1 · Maurice · 2004 [cited by applicant]
US 20040215178A1 · Maurice · 2004 [cited by applicant]
US 20040215294A1 · Littrup et al. · 2004 [cited by applicant]
US 20040215295A1 · Littrup et al. · 2004 [cited by applicant]
US 20040220497A1 · Findlay et al. · 2004 [cited by applicant]
US 20040220648A1 · Carroll · 2004 [cited by applicant]
US 20040225276A1 · Burgess · 2004 [cited by applicant]
US 20040243116A1 · Joye et al. · 2004 [cited by applicant]
US 20040267248A1 · Duong et al. · 2004 [cited by applicant]
US 20040267257A1 · Bourne et al. · 2004 [cited by applicant]
US 20050004563A1 · Racz et al. · 2005 [cited by applicant]
US 20050177147A1 · Vancelette et al. · 2005 [cited by applicant]
US 20050177148A1 · van der Walt et al. · 2005 [cited by applicant]
US 20050182394A1 · Spero et al. · 2005 [cited by applicant]
US 20050203505A1 · Megerman et al. · 2005 [cited by applicant]
US 20050203593A1 · Shanks et al. · 2005 [cited by applicant]
US 20050209565A1 · Yuzhakov et al. · 2005 [cited by applicant]
US 20050209587A1 · Joye et al. · 2005 [cited by applicant]
US 20050224086A1 · Nahon · 2005 [cited by applicant]
US 20050228288A1 · Hurst · 2005 [cited by applicant]
US 20050251103A1 · Steffen et al. · 2005 [cited by applicant]
US 20050261753A1 · Littrup et al. · 2005 [cited by applicant]
US 20050276759A1 · Roser et al. · 2005 [cited by applicant]
US 20050281530A1 · Rizoiu et al. · 2005 [cited by applicant]
US 20050283148A1 · Janssen et al. · 2005 [cited by applicant]
US 20060009712A1 · Van Bladel et al. · 2006 [cited by applicant]
US 20060015092A1 · Joye et al. · 2006 [cited by applicant]
US 20060069385A1 · Lafontaine et al. · 2006 [cited by applicant]
US 20060079914A1 · Modesitt et al. · 2006 [cited by applicant]
US 20060084962A1 · Joye et al. · 2006 [cited by applicant]
US 20060089688A1 · Panescu · 2006 [cited by applicant]
US 20060111732A1 · Gibbens et al. · 2006 [cited by applicant]
US 20060129142A1 · Reynolds · 2006 [cited by applicant]
US 20060142785A1 · Modesitt et al. · 2006 [cited by applicant]
US 20060173469A1 · Klein et al. · 2006 [cited by applicant]
US 20060189968A1 · Howlett et al. · 2006 [cited by applicant]
US 20060190035A1 · Hushka et al. · 2006 [cited by applicant]
US 20060200117A1 · Hermans · 2006 [cited by applicant]
US 20060212028A1 · Joye et al. · 2006 [cited by applicant]
US 20060212048A1 · Crainich · 2006 [cited by applicant]
US 20060223052A1 · MacDonald et al. · 2006 [cited by applicant]
US 20060224149A1 · Hillely · 2006 [cited by applicant]
US 20060258951A1 · Bleich et al. · 2006 [cited by applicant]
US 20070060921A1 · Janssen et al. · 2007 [cited by applicant]
US 20070088217A1 · Babaev · 2007 [cited by applicant]
US 20070129714A1 · Elkins et al. · 2007 [cited by applicant]
US 20070156125A1 · DeLonzor · 2007 [cited by applicant]
US 20070161975A1 · Goulko · 2007 [cited by applicant]
US 20070167943A1 · Janssen et al. · 2007 [cited by applicant]
US 20070167959A1 · Modesitt et al. · 2007 [cited by applicant]
US 20070179509A1 · Nagata et al. · 2007 [cited by applicant]
US 20070198071A1 · Ting et al. · 2007 [cited by applicant]
US 20070255362A1 · Levinson et al. · 2007 [cited by applicant]
US 20070270925A1 · Levinson · 2007 [cited by applicant]
US 20080051775A1 · Evans · 2008 [cited by applicant]
US 20080051776A1 · Bliweis et al. · 2008 [cited by applicant]
US 20080077201A1 · Levinson et al. · 2008 [cited by applicant]
US 20080077202A1 · Levinson · 2008 [cited by applicant]
US 20080077211A1 · Levinson et al. · 2008 [cited by applicant]
US 20080154254A1 · Burger et al. · 2008 [cited by applicant]
US 20080183164A1 · Elkins et al. · 2008 [cited by applicant]
US 20080200910A1 · Burger et al. · 2008 [cited by applicant]
US 20080287839A1 · Rosen et al. · 2008 [cited by applicant]
US 20090018623A1 · Levinson et al. · 2009 [cited by applicant]
US 20090018624A1 · Levinson et al. · 2009 [cited by applicant]
US 20090018625A1 · Levinson et al. · 2009 [cited by applicant]
US 20090018626A1 · Levinson et al. · 2009 [cited by applicant]
US 20090018627A1 · Levinson et al. · 2009 [cited by applicant]
US 20090118722A1 · Ebbers et al. · 2009 [cited by applicant]
US 20090171203A1 · Avital et al. · 2009 [cited by applicant]
US 20090171334A1 · Elkins et al. · 2009 [cited by applicant]
US 20090248001A1 · Burger et al. · 2009 [cited by applicant]
US 20090264876A1 · Roy et al. · 2009 [cited by applicant]
US 20090299357A1 · Zhou · 2009 [cited by applicant]
US 20090306639A1 · Nevo et al. · 2009 [cited by applicant]
US 20100179527A1 · Watson · 2010 [cited by examiner]
US 20110144631A1 · Elkins et al. · 2011 [cited by applicant]
US 20120029495A1 · Wittenberger · 2012 [cited by applicant]
US 20120065629A1 · Elkins et al. · 2012 [cited by applicant]
US 20120089211A1 · Curtis et al. · 2012 [cited by applicant]
US 20120108953A1 · Markowitz et al. · 2012 [cited by applicant]
US 20120259322A1 · Fourkas et al. · 2012 [cited by applicant]
US 20120265187A1 · Palmer, III et al. · 2012 [cited by applicant]
US 20120265278A1 · Fourkas et al. · 2012 [cited by applicant]
US 20130184696A1 · Fourkas et al. · 2013 [cited by applicant]
US 20130190745A1 · Fourkas et al. · 2013 [cited by applicant]
US 20130324990A1 · Burger et al. · 2013 [cited by applicant]
US 20140249519A1 · Burger et al. · 2014 [cited by applicant]
US 20150126988A1 · Hinton et al. · 2015 [cited by applicant]
US 20180116705A1 · Lee et al. · 2018 [cited by applicant]
US 20190142494A1 · Cross et al. · 2019 [cited by applicant]
CA 2643474 · 2007 [cited by applicant]
EP 0043447 · 1982 [cited by applicant]
EP 0777123A2 · 1997 [cited by applicant]
EP 0955012A1 · 1999 [cited by applicant]
EP 1074273 · 2001 [cited by applicant]
EP 1377327 · 2004 [cited by applicant]
EP 1862125 · 2007 [cited by applicant]
EP 3065658 · 2016 [cited by applicant]
GB 1360353A · 1974 [cited by applicant]
GB 1402632 · 1975 [cited by applicant]
JP 60013111A · 1985 [cited by applicant]
JP 04357945A · 1992 [cited by applicant]
JP 0538347A · 1993 [cited by applicant]
JP 10014656A · 1998 [cited by applicant]
JP 2001178737A · 2001 [cited by applicant]
JP 2005080988A · 2005 [cited by applicant]
JP 2006130055A · 2006 [cited by applicant]
JP 2008515469A · 2008 [cited by applicant]
RU 2254060C2 · 2005 [cited by applicant]
WO 9749344A1 · 1997 [cited by applicant]
WO 0197702A1 · 2001 [cited by applicant]
WO 0202026A1 · 2002 [cited by applicant]
WO 02092153A2 · 2002 [cited by applicant]
WO 2004039440 · 2004 [cited by applicant]
WO 2004045434A2 · 2004 [cited by applicant]
WO 2004089460 · 2004 [cited by applicant]
WO 2005000106 · 2005 [cited by applicant]
WO 2005079321 · 2005 [cited by applicant]
WO 2005096979A1 · 2005 [cited by applicant]
WO 2006012128 · 2006 [cited by applicant]
WO 2006023348A1 · 2006 [cited by applicant]
WO 2006044727A2 · 2006 [cited by applicant]
WO 2006062788A2 · 2006 [cited by applicant]
WO 2006125835A1 · 2006 [cited by applicant]
WO 2006127467A2 · 2006 [cited by applicant]
WO 2007025106A2 · 2007 [cited by applicant]
WO 2007037326A1 · 2007 [cited by applicant]
WO 2007089603 · 2007 [cited by applicant]
WO 2007129121 · 2007 [cited by applicant]
WO 2007135629 · 2007 [cited by applicant]
WO 2008021920A2 · 2008 [cited by applicant]
WO 2009026471 · 2009 [cited by applicant]
WO 2010075438A1 · 2010 [cited by applicant]
WO 2015069792A1 · 2015 [cited by applicant]
“Cryopen Webpage”, available online at http://cryopen.com/ , 2006-2008 , 2 pages. [cited by applicant]
“Cryoprobe”, One Med Group, LLC, Available online at: http://www.onemedgroup.com/ , Feb. 4, 2008 , pp. 1-2. [cited by applicant]
“CryoProbe™”, Cryosurgical Concepts, Inc., Available online at: http://www.cryo-surgical.com , Feb. 8, 2008 , 2 pages. [cited by applicant]
“CyroPen, LLC Launches Revolutionary, State-of-the-Art Medical Device, the Dure of Cryosurgery in a Pend”, CryoPen, LLC [Press Release], Online Available At: http://cryopen.com/press.htm , Apr. 27, 2007 , 3 pages. [cited by applicant]
“Metrum Cryofiex, Cryoablation in Pain Management Brochure”, , 2012, 5 pages. [cited by applicant]
“Metrum Cryofiex, Cryosurgery Probes and Accessories Catalogue”, 2009 , 25 pages. [cited by applicant]
“New Technology Targets Motor Nerves”, Advanced Cosmetic Intervention, Inc., Available Online At: http://www.acisurgery.com , 2007 , 1 page. [cited by applicant]
“Symmetric-Key Algorithm”, Wikipedia, Available Online at, http://en.wikipedia.org/w/index.php?title=Symmetrickeyalgorith m&oldid=24675570 , Oct. 3, 2005 , 1 page. [cited by applicant]
U.S. Appl. No. 61/116,050 , “U.S. Provisional Application”, Cryosurgical Safety Valve Arrangement and Methods for Its Use in Cosmetic and Other Treatment , filed Nov. 19, 2008 , 35 pages. [cited by applicant]
U.S. Appl. No. 61/801,268 , “U.S. Provisional Application No. , Cryogenic Blunt Dissection Methods and Devices”, filed Mar. 15, 2013. [cited by applicant]
Dasiou-Plakida , “Fat Injections for Facial Rejuvenation: 17 Years Experience in 1720 Patients”, Journal of Cosmetic Dermatology, vol. 2, Issue 3-4 , Oct. 22, 2004 , pp. 119-125. [cited by applicant]
Foster , et al. , “Radiofrequency Ablation of Facial Nerve Branches Controlling Glabellar Frowning”, Dermatol Surg, vol. 35, Issue 12 , Dec. 2009 , pp. 1908-1917. [cited by applicant]
Har-Shai , et al. , “Effect of Skin Surface Temperature on Skin Pigmentation During Contact and Intralesional Cryosurgery of Hypertrophic Scars and Kleoids”, Journal of the European Academy of Dermatology and Venereolog… [cited by applicant]
Magalov , et al. , “Isothermal Volume Contours Generated in a Freezing Gel by Embedded Cryo-Needles with Applications to Cryo-Surgery”, Cryobiology, vol. 55, Issue 2 , Oct. 2007 , pp. 127-137. [cited by applicant]
Rewcastle , et al. , “A Model for the Time Dependent Three-Dimensional Thermal Distribution within Iceballs Surrounding Multiple Cryoprobes”, Medical Physics, vol. 28, Issue 6 , Jun. 2001 , pp. 1125-1137. [cited by applicant]
Rutkove , “Effects of Temperature on Neuromuscular Electrophysiology”, Muscles and Nerves, vol. 24, Issue 7 , Jul. 2001 , pp. 867-882. [cited by applicant]
Utley , et al. , “Radiofrequency Ablation of the Nerve to the Corrugator Muscle for Elimination of Glabellar Furrowing”, Archives of Facial Plastic Surgery, vol. 1, Issue 1 , Jan.-Mar. 1999 , pp. 46-48. [cited by applicant]
Yang , et al. , “Apoptosis Induced by Cryo-Injury in Human Colorectal Cancer Cells is Associated with Mitochondrial Dysfunction”, International Journal of Cancer, vol. 103, Issue 3 , Jan. 2003 , pp. 360-369. [cited by applicant]