Automated analysis of OCT retinal scans
The present invention is related to improved methods for analysis of images of the vitreous and/or retina and/or choroid obtained by optical coherence tomography and to methods for making diagnoses of retinal disease based on the reflectivity profiles of various vitreous and/or retinal and/or choroidal layers of the retina.
1. A workstation comprising:
a display device configured to display an OCT retinal image received from an SD-OCT device;
a user input device configured to enable a user to indicate a portion of an edge of at least one the retinal layer on the displayed OCT retinal image; and
a computer configured to:
receive the indicated portion of an edge of at least one retinal layer on the displayed OCT retinal image;
calculate a patient reflectivity profile for the indicated portion of an edge of at least one retinal layer on the displayed OCT retinal image and using the reflectivity profile to identify potential retinal locations of the designated retinal layer across the entire image;
transmit the patient reflectivity profile to a server remote from the user computer, wherein the remote server comprises a plurality of OCT datasets from normal and diseased retinas, wherein the remote server is configured to apply one or more machine learning algorithms to analyze the patient reflectivity profile in relation to the plurality of OCT datasets from normal and diseased retinas to generate one or more algorithms associated with the reflectivity profile for the designated retinal layer, wherein the algorithm identifies lesions in one or more retinal layers and the type and/or location of the lesion is used to diagnose a disease or the retina and/or designate a stage of severity of a disease of the retina; and
receive from the remote server an output selected from the group consisting of an image of the patient retina with computer-generated traces defining one or more layers in the image of the patient retina, association of a disease state with the reflectivity profiles associated with one or more retinal layers in the patient retina, an identification of lesions in one or more retinal layers, an image of one or more lesions in one or more retinal layers, an identification of disease of the retina associated with one or more lesions in one or more retinal layers, a designation of a stage of severity of a disease of the retina based on one or more identified lesions in one or more retinal layers, and combinations thereof.
2. The workstation of claim 1 , wherein the algorithm associates the reflectivity profile of the designated retinal layer with a disease state of the retina wherein the disease state is selected from the group consisting of Age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa, uveitis, central vein occlusion, and other retinal degenerations.
3. The workstation of claim 1 , wherein the work station is networked with an SD-OCT device.
4. The workstation of claim 3 , wherein the SD-OCT device is utilized to obtain an OCT dataset of the scan of the patient's retina.
5. The workstation of claim 1 , wherein the server remote from the work station is a cloud based server.