Treatment of acute medical conditions
Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.
1. A computer-implemented method for treating an acute medical condition involving stimulating neural activity of one or more nerves adjacent to a splenic arterial loop comprising:
controlling at least one electrode in signaling contact with the one or more nerves wherein at least one controller is electrically coupled to the at least one electrode, the at least one controller configured to control operation of the at least one electrode to apply an electrical signal to the one or more nerves, wherein the electrical signal has a waveform that comprises one or more pulse trains, and
applying a charge density per phase to the one or more nerves, wherein the charge density per phase applied to the one or more nerves by the electrical signal is ≥40 μC per cm 2 per phase and ≤1100 μC per cm 2 per phase, wherein the electrical signal produces an improvement in a physiological parameter indicative of treatment of the acute medical condition, wherein the improvement in the physiological parameter is any of the group consisting of: restoring a body temperature to between 36° C. and 38° C., restoring a heart rate to 60-100 bpm, restoring a systemic arterial pressure to between 90/60 mmHg and 150/90 mmHg, restoring a systemic venous pressure to 5 mmHg in a right atrium and 8 mmHg in a left atrium, restoring a pulmonary pressure to 15 mmHg, restoring a central venous pressure to in a range of 3 to 8 mmHg, restoring a breathing rate to 8-14 breaths per minute, an increase in oxygen saturation to ≥94%, an increase in an arterial partial pressure of oxygen to 12-15 kPa, restoring an arterial partial pressure of carbon dioxide to 4.4-6.1 kPa, a reduction of pain sensation, restoring urine output to ≥5 ml/kg/hr, a reduction in a level of lactate, a change in a level of blood glucose, a change in a level of base deficit in blood, a change in a level of arterial pH, lowering levels of pulmonary vascular resistance while increasing systemic vascular resistance and increasing pulmonary capillary wedge pressure, reducing levels of lipases, and reducing levels of amylases.
2. The method of claim 1 , wherein the acute medical condition is shock.
3. The method of claim 1 , wherein the acute medical condition is episodes of lupus.
4. The method of claim 1 , wherein the acute medical condition is hemorrhaging.
5. The method of claim 1 , wherein the acute medical condition is trauma.
6. The method of claim 1 , wherein the acute medical condition is allograph/graph rejection.
7. The method of claim 1 , wherein the acute medical condition is an effect of a bacterial endotoxin.
8. The method of claim 1 , further comprising the step of proving a neural interface, the neural interface comprising the at least one electrode.
9. The method of claim 8 , wherein the neural interface is configured to be placed around the splenic arterial loop.
10. The method of claim 8 , wherein the neural interface is configured to be placed on the splenic arterial loop.