IP Library Granted Patent US 12,372,156
Granted Patent B2
US 12,372,156 · App. 18/221,028 · Granted Jul 29, 2025

Encapsulated system for pressurized fluid processes

Inventors: Michael C. Gagne (Carson City, NV); Dean C. Richards (Simi Valley, CA); Steven V. Cates (Corona, CA)
Assignee: Repligen Corporation
F16K7/04F16K27/0236F16L57/00F16L57/02F16L2201/20
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Quick Facts
Patent No.
US 12,372,156
App. No.
18/221,028
Granted
Jul 29, 2025
Kind
B2
Abstract

Fluid management systems for handling pressurized fluid connect various subsystems or subunits without the need to use reinforced tubing. The system utilizes one or more segments of unreinforced conduit that are encapsulated at various points along a length of the segment with one or more rigid encapsulating members. The unreinforced conduit may be made a disposable element while the rigid encapsulating members may be re-used. In one aspect, the encapsulating member may include a two-part valve body that surrounds and encapsulates a portion of the unreinforced conduit. In another aspect, the encapsulating member may include a two-part jacket that surrounds and encapsulates a portion of the unreinforced conduit. The two-part valve bodies and two-part jackets may be joined at various points within the system as part of the overall flow system.

Claims (30)

1. A fluid management system, comprising:

a two-part jacket including a first half and a second half, the first half defining a semi-circular inner surface, the second half defining a semi-circular inner surface, the first half and the second half configured to mate with each other to define a passageway through the two-part jacket, the passageway arranged and configured to receive and encapsulate a conduit; and

a two-part pinch valve coupled with the two-part jacket, the two-part pinch valve including a first half and a second half configured to mate with each other to define a valve passageway therethrough, the valve passageway arranged and configured to receive and encapsulate a straight portion of the conduit therein, the two-part pinch valve including an actuator arranged and configured to contact the conduit to modulate flow within the conduit, the two-part pinch valve comprising a flange at one end thereof, the flange dimensioned to receive a flange disposed at one end of the conduit;

wherein the actuator is positioned at a fixed angle relative to the valve passageway such that an end portion of the actuator is engageable with the straight portion of the conduit at the fixed angle, and wherein the fixed angle is greater than zero degrees but less than ninety-degrees.

2. The fluid management system of claim 1 , wherein the first and second halves of the two-part jacket form a bend.

3. The fluid management system of claim 2 , wherein the bend is approximately ninety-degrees.

4. The fluid management system of claim 1 , wherein the first half and the second half of the two-part pinch valve are connected via a hinge.

5. The fluid management system of claim 4 , wherein the first half and the second half of the two-part pinch valve are secured to each other via a threaded latch and a knob.

6. The fluid management system of claim 1 , wherein the two-part pinch valve includes a manually operated bonnet arranged and configured to move the actuator.

7. The fluid management system of claim 6 , wherein the actuator contacts and pinches the conduit to adjust the flow therethrough.

8. The fluid management system of claim 1 , wherein the first half and the second half of the two-part jacket are connected via a hinge and the first half and the second half of the two-part jacket are secured to each other via a friction fit.

9. The fluid management system of claim 1 , wherein the two-part pinch valve is coupled to the two-part jacket via an interlocking structure.

10. The fluid management system of claim 9 , wherein the interlocking structure includes a recess formed in the two-part pinch valve arranged and configured to receive an end of the two-part jacket.

11. The fluid management system of claim 9 , wherein the interlocking structure includes a shouldered end formed on the two-part jacket and a recess formed in the two-part pinch valve arranged and configured to receive the shouldered end in a tight-fitting arrangement.

12. A fluid management system, comprising:

an unreinforced polymer conduit comprising a flange at one end thereof;

a two-part jacket including a first half and a second half, the first half defining a semi-circular inner surface, the second half defining a semi-circular inner surface, the first half and the second half configured to mate with each other to define a passageway through the two-part jacket, the passageway arranged and configured to receive the unreinforced polymer conduit; and

a two-part pinch valve coupled with the two-part jacket, the two-part pinch valve including a first half and a second half configured to mate with each other to define a valve passageway therethrough, the valve passageway arranged and configured to receive and encapsulate a straight portion of the unreinforced polymer conduit therein, the two-part pinch valve including an actuator to pinch the straight portion of the unreinforced polymer conduit to adjust the flow therethrough; the two-part pinch valve comprising a flange at one end thereof, the flange configured to receive the flange of the unreinforced polymer conduit therein;

wherein the actuator is positioned at a fixed angle relative to the valve passageway such that an end portion of the actuator is engageable with the straight portion of the conduit at the fixed angle, and wherein the fixed angle is greater than zero degrees but less than ninety-degrees.

13. The fluid management system of claim 12 , wherein the bend is approximately ninety-degrees.

14. The fluid management system of claim 12 , wherein the first half and the second half of the two-part pinch valve are connected via a hinge; and the first half and the second half of the two-part pinch valve are secured to each other via a threaded latch and a knob.

15. The fluid management system of claim 12 , wherein the two-part pinch valve includes a manually operated bonnet arranged and configured to move the actuator back and forth to modulate flow within the unreinforced polymer conduit.

16. The fluid management system of claim 12 , wherein the two-part pinch valve is coupled to the two-part jacket via an interlocking structure.

17. The fluid management system of claim 16 , wherein the interlocking structure includes a recess formed in the two-part pinch valve arranged and configured to receive an end of the two-part jacket.

18. The fluid management system of claim 16 , wherein the interlocking structure includes a shouldered end formed on the two-part jacket and a recess formed in the two-part pinch valve arranged and configured to receive the shouldered end in a tight-fitting arrangement.

19. A fluid management system, comprising:

an unreinforced polymer conduit comprising a flange at one end thereof;

a two-part jacket including a first half and a second half, the first half defining a semi-circular inner surface, the second half defining a semi-circular inner surface, the first half and the second half configured to mate with each other to define a passageway through the two-part jacket, the passageway arranged and configured to receive the unreinforced polymer conduit; and

a pinch valve coupled with the two-part jacket via an interlocking structure, the pinch valve including a valve passageway therethrough, the valve passageway arranged and configured to receive and encapsulate a straight portion of the unreinforced polymer conduit therein, the pinch valve including an actuator to pinch the straight portion of the unreinforced polymer conduit to adjust the flow therethrough; the pinch valve further comprising a flange at one end thereof, the flange configured to receive the flange of the unreinforced polymer conduit therein;

wherein the actuator is positioned at a fixed angle relative to the valve passageway such that an end portion of the actuator is engageable with the straight portion of the conduit at the fixed angle, and wherein the fixed angle is greater than zero degrees but less than ninety-degrees.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 19, 2024
From: ALPHINITY, LLC
To: REPLIGEN CORPORATION
Reel/Frame 068636/0413 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 12, 2024
From: ALPHINITY, LLC
To: REPLIGEN CORPORATION
Reel/Frame 067971/0520 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 12, 2024
From: GAGNE, MICHAEL C.; RICHARDS, DEAN C.; CATES, STEVEN V.
To: ALPHINITY, LLC
Reel/Frame 067971/0531 →
Continuity (5)
Continuation 17835166 · Jun 8, 2022
Continuation 16994436 · Aug 14, 2020
Continuation 15535601
Provisional Application 62094829 · Dec 19, 2014
Related Publication 20230358321A1 · Nov 9, 2023
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