TIE-LAYER COATING FOR CATHETER LINERS
The disclosure provides coated tubings, including a layer of PEBA (or other polymer) on an etched polymeric tubing. The layer of PEBA (or other polymer) can have a low thickness, e.g., less than 1 micron and can provide for efficient bonding to an overlying jacket layer. The disclosure further provides methods of making and using such coated tubings.
1 . A coated tubing, comprising an etched PTFE tubing with an inner surface and an outer surface, wherein the outer surface comprises a layer of PEBA thereon with an average thickness of less than 1 micron.
2 . The coated tubing of claim 1 , where the PEBA has a durometer of 25 to 72.
3 . The coated tubing of claim 1 , prepared using a PEBA-containing solution.
4 . The coated tubing of claim 3 , wherein the PEBA-containing solution comprises a solvent selected from methanol, ethanol, 2-methyl-2-propanol, 1-butanol, 2-butanol, and mixtures thereof.
5 . The coated tubing of claim 3 , where the PEBA-containing solution comprises 1-butanol.
6 . The coated tubing of claim 3 , wherein the PEBA is present in the PEBA-containing solution at a wt/vol ratio of less than 0.10 g/mL.
7 . The coated tubing of claim 3 , wherein the PEBA-containing solution is at a temperature of 20° C. to 100° C. at the time of coating.
8 . The coated tubing of claim 1 , wherein the average thickness of the layer of PEBA is below 0.9 μm.
9 . The coated tubing of claim 8 , where the average thickness of the layer of PEBA is below 0.8 μm.
10 . The coated tubing of claim 1 , further comprising a jacket layer comprising PEBA or a polyamide coated on the layer of PEBA.
11 . The coated tubing of claim 1 , wherein the layer of PEBA consists essentially of PEBA.
12 . The coated tubing of claim 1 , wherein the layer of PEBA comprises one or more additives.
13 . The coated tubing of claim 1 , wherein the layer of PEBA is substantially free of residual solvent.
14 . The coated tubing of claim 1 , wherein the coated tubing is a catheter liner.
15 . A catheter comprising the coated tubing of claim 14 .
16 . A coated tubing comprising a tubing comprising a fluoropolymer, with an inner surface and an outer surface, wherein the outer surface comprises a tie-layer thereon, wherein the tie-layer has an average thickness of less than 1 micron.
17 . A method of preparing a coated tubing with an inner surface and an outer surface, comprising:
providing an etched PTFE tubing with an inner surface and an outer surface;
dissolving PEBA in one or more solvents to provide a PEBA-containing solution; and
applying the PEBA-containing solution to the outer surface of the etched PTFE tubing to give a layer of PEBA thereon with an average thickness of less than 1 micron.
18 . The method of claim 17 , wherein the dissolving comprises heating and/or agitating the PEBA in one or more solvents.
19 . The method of claim 17 , wherein the PEBA-containing solution comprises a solvent selected from non-aromatic alcohols.
20 . The method of claim 19 , wherein the non-aromatic alcohol is selected from methanol, ethanol, 2-methyl-2-propanol, 1-butanol, 2-butanol, and mixtures thereof.