Curcumin compositions and methods of use as an NK3 antagonist
Disclosed herein are compositions for treating, ameliorating, preventing, or reducing the symptoms associated with menopause and/or hot flashes. The compositions disclosed herein comprise a curcumin composition, a green tea extract composition, and a phycocyanin composition that act as neurokinin 3 receptor antagonists. Also described herein are methods utilizing the aforementioned compositions.
1. A dietary supplement comprising an amount of a curcumin composition, an amount of a green tea extract composition, and an amount of a phycocyanin composition, wherein the amount of the curcumin composition, the amount of the green tea extract composition, and the amount of the phycocyanin composition comprise a synergistic ratio.
2. The dietary supplement of claim 1 , wherein the synergistic ratio is about 6:3:1, curcumin composition to green tea extract composition to phycocyanin composition, respectively.
3. The dietary supplement of claim 1 , wherein the synergistic ratio is about 4.5:4.5:1, curcumin composition to green tea extract composition to phycocyanin composition, respectively.
4. The dietary supplement of claim 1 , wherein the synergistic ratio is about 7.2:1.8:1, curcumin composition to green tea extract composition to phycocyanin composition, respectively.
5. The dietary supplement of claim 1 , wherein the amount of the curcumin composition is about 100 mg to about 750 mg.
6. The dietary supplement of claim 1 , wherein the amount of the green tea extract composition is about 100 mg to about 500 mg.
7. The dietary supplement of claim 1 , wherein the amount of the phycocyanin composition is about 100 mg.
8. The dietary supplement of claim 1 , wherein the curcumin composition comprises a compound selected from the group consisting of diferuloylmethane, demethoxycurcumin, bis-demethoxycurcumin, tetrahydrocurcumin, dihydrocurcumin, hexahydrocurcumin, octohydrocurcumin, and any combination thereof.
9. The dietary supplement of claim 1 , wherein the green tea extract comprises a compound selected from the group consisting of epigallocatechin gallate, epicatechin, epigallocatechin, and epicatechin gallate, and any combination thereof.
10. The dietary supplement of claim 1 , wherein the phycocyanin composition comprises one or more phycocyanin-related compounds.
11. The dietary supplement of claim 10 , wherein the one or more phycocyanin-related compounds comprises phycocyanin, extracts of phycocyanin, phycocyanin peptides, phycocyanin oligopeptides, or any combination thereof.
12. The dietary supplement of claim 1 further comprises one or more supplement ingredients.
13. The dietary supplement of claim 1 , wherein the dietary supplement is formulated for sustained release.
14. The dietary supplement of claim 1 , wherein the dietary supplement is administered to a subject for treating, ameliorating, or reducing symptoms associated with menopause in the subject.
15. The dietary supplement of claim 1 , wherein the dietary supplement is administered to a subject for treating, ameliorating, or reducing hot flashes, maintaining a healthy level of hot flashes in the subject, or both.
16. A pharmaceutical composition comprising an amount of a curcumin composition, an amount of a green tea extract composition, and an amount of a phycocyanin composition, wherein the amount of the curcumin composition, the amount of the green tea extract composition, and the amount of the phycocyanin composition comprise a synergistic ratio.
17. The pharmaceutical composition of claim 16 , wherein the synergistic ratio is about 6:3:1, curcumin composition to green tea extract composition to phycocyanin composition, respectively.
18. The pharmaceutical composition of claim 16 , wherein the synergistic ratio is about 4.5:4.5:1, curcumin composition to green tea extract composition to phycocyanin composition, respectively.
19. The pharmaceutical composition of claim 16 , wherein the synergistic ratio is about 7.2:1.8:1, curcumin composition to green tea extract composition to phycocyanin composition, respectively.
20. The pharmaceutical composition of claim 16 , wherein the amount of the curcumin composition is about 100 mg to about 750 mg.
21. The pharmaceutical composition of claim 16 , wherein the amount of the green tea extract composition is about 100 mg to about 500 mg.
22. The pharmaceutical composition of claim 16 , wherein the amount of the phycocyanin composition is about 100 mg.
23. The pharmaceutical composition of claim 16 , wherein the curcumin composition comprises a compound selected from the group consisting of diferuloylmethane, demethoxycurcumin, bis-demethoxycurcumin, tetrahydrocurcumin, dihydrocurcumin, hexahydrocurcumin, octohydrocurcumin, and any combination thereof.
24. The pharmaceutical composition of claim 16 , wherein the green tea extract comprises a compound selected from the group consisting of epigallocatechin gallate, epicatechin, epigallocatechin, and epicatechin gallate, and any combination thereof.
25. The pharmaceutical composition of claim 16 , wherein the phycocyanin composition comprises one or more phycocyanin-related compounds.
26. The pharmaceutical composition of claim 25 , wherein the one or more phycocyanin-related compounds comprises phycocyanin, extracts of phycocyanin, phycocyanin peptides, phycocyanin oligopeptides, or any combination thereof.
27. The pharmaceutical composition of claim 16 , wherein the composition is enteric coated.
28. The pharmaceutical composition of claim 16 , wherein the composition comprises a sustained-release matrix.
29. The pharmaceutical composition of claim 16 , wherein the composition is administered to a subject for treating, ameliorating, or reducing symptoms associated with menopause in the subject.
30. The pharmaceutical composition of claim 16 , wherein the composition is administered to a subject for treating, ameliorating, or reducing hot flashes, maintaining a healthy level of hot flashes in the subject, or both.