IMPROVED FOAMING BIOSURFACTANTS
The present invention provides modified sophorolipids comprising taurine for improved foaming performance. The present invention also provides compositions comprising the modified sophorolipids formulated for cosmetics and personal care products. Further provided are methods for improving skin conditions, enhancing and/or maintaining the oral health, and cleaning, enhancing and/or maintaining heathy hair of a subject.
1 . A compound having a structure selected from:
wherein R 1 and R 2 are each independently selected from hydrogen, alkyl, substituted alkyl, acyl, substituted acyl, alkenyl, and substituted alkenyl; R 3 is hydrogen or alkyl; R 4 is alkane, alkylene, substituted alkylene, alkenylene or substituted alkenylene; and R is hydrogen or a cation selected from Na + , K + , Li + , Cs + , Rb + , Ca 2+ , Mg 2+ and NH 4 + .
2 . The compound of claim 1 , wherein R 1 and R 2 are hydrogen; and R 3 is methyl.
3 . The compound of claim 1 , wherein R 4 is C5-C15 alkylene, or C5-C15 alkenylene.
4 . The compound of claim 1 , which has a structure of:
wherein R is hydrogen or a cation selected from Na + , K + , Li + , Cs + , Rb + , Ca 2+ , Mg 2+ and NH 4 + .
5 . The compound of claim 1 , which has a structure of:
wherein R is hydrogen or a cation selected from Na + , K + , Li + , Cs + , Rb + , Ca 2+ , Mg 2+ and NH 4 + .
6 . The compound of claim 1 , which has a structure of formula (III):
wherein R is hydrogen or a cation selected from Na + , K + , Li + , Cs + , Rb + , Ca 2+ , Mg 2+ and NH 4 + .
7 . The compound of claim 1 , which has a structure of:
wherein R is hydrogen or a cation selected from Na + , K + , Li + , Cs + , Rb + , Ca 2+ , Mg 2+ and NH 4 + .
8 . The compound of claim 1 , which has a structure of:
wherein R is hydrogen or a cation selected from Na + , K + , Li + , Cs + , Rb + , Ca 2+ , Mg 2+ and NH 4 + .
9 . A composition comprising the compound of claim 1 .
10 . The composition of claim 9 , further comprising a pharmaceutically or cosmetically acceptable carrier.
11 . The composition of claim 9 , further comprising one or more ingredients selected from viscosity modifiers, skin conditioners, anti-aging components, exfoliating agents, antioxidants, fragrances, and preservatives.
12 . The composition of claim 9 , wherein the composition is formulated as a suspension, emulsion, nano-emulsion, hydrogel, multiphase solution, liposomal dispersion, lotion, cream, gel, foam, ointment, paste, spray, conditioner, shampoo, cleanser, micellar water, tonic, toothpaste, mouthwash or makeup.
13 . A method for improving the foaming performance of a sophorolipid, the method comprising providing the sophorolipid, and functionalizing the sophorolipid by covalently linking to taurine through an amide bond or amine bond.
14 . The method of claim 13 , wherein the sophorolipid has a structure of formula (I):
wherein R 1 and R 2 are each independently selected from hydrogen, alkyl, substituted alkyl, acyl, substituted acyl, alkenyl, and substituted alkenyl; R 3 is hydrogen or alkyl; and R 4 is alkane, alkylene, substituted alkylene, alkenylene or substituted alkenylene.
15 . The method of claim 13 , wherein R 1 and R 2 are hydrogen; and R 3 is methyl.
16 . The method of claim 13 , wherein R 4 is C5-C15 alkane, C5-C15 alkylene, or C5-C15 alkenylene.
17 . A method for producing the composition of claim 9 , the method comprising providing a sophorolipid, functionalizing the sophorolipid by covalently linking to taurine through an amide bond or amine bond, and mixing the functionalized sophorolipid with a solvent.
18 . A method for improving a skin condition of a subject, wherein the method applying the composition of claim 9 to an area of the skin of the subject.
19 . A method for enhancing and/or maintaining the oral health of a subject, wherein the method comprises applying the composition of claim 9 to a surface of the subject's mouth, lips or oral cavity.
20 . A method for cleaning, enhancing and/or maintaining heathy hair of a subject, wherein the method comprises applying the composition of claim 9 to the hair of the subject.