COMBINATION VACCINE FOR PROTECTING SWINE AGAINST VARIOUS DISORDERS
The present invention pertains to a vaccine comprising in combination non-replicating immunogen of porcine circo virus type 2 (PCV2), non-replicating immunogen of Mycoplasma hyopneumoniae and conjugated deoxynivalenol (DON) for protecting swine against an infection with porcine circo virus type 2, an infection with Mycoplasma hyopneumoniae and DON induced mycotoxicosis.
1 . A vaccine comprising in combination a non-replicating immunogen of porcine circo virus type 2 (PCV2), a non-replicating immunogen of Mycoplasma hyopneumoniae and a conjugated deoxynivalenol (DON) for protecting swine against an infection with porcine circo virus type 2, an infection with Mycoplasma hyopneumoniae and DON induced mycotoxicosis.
2 . A vaccine according to claim 1 , characterised in that the non-replicating immunogen of PCV2 is an ORF2 protein of PCV2.
3 . A vaccine according to claim 1 , characterised in that the non-replicating immunogen of PCV2 is recombinantly expressed ORF2 protein of PCV2.
4 . A vaccine according to claim 1 , characterised in that the non-replicating immunogen of Mycoplasma hyopneumoniae is a Mycoplasma hyopneumoniae bacterin.
5 . A vaccine according to claim 1 , characterised in that the non-replicating immunogen of Mycoplasma hyopneumoniae comprises killed whole Mycoplasma hyopneumoniae.
6 . A vaccine according to claim 1 , characterised in that the conjugated DON is DON conjugated to a protein having a molecular mass above 10.000 Da.
7 . A vaccine according to claim 1 , characterised in that the conjugated DON is DON conjugated to keyhole limpet hemocyanin (KLH) or ovalbumin (OVA).
8 . A vaccine according to claim 1 , characterised in that the vaccine comprises a non-replicating immunogen of Lawsonia intracellularis.
9 . A vaccine according to claim 1 , characterised in that the vaccine comprises killed whole cells of Lawsonia intracellularis.
10 . A method of protecting a swine against an infection with porcine circo virus type 2, an infection with Mycoplasma hyopneumoniae and DON induced mycotoxicosis comprising administering to the swine a vaccine comprising a non-replicating immunogen of porcine circo virus type 2 (PCV2), a non-replicating immunogen of Mycoplasma hyopneumoniae and conjugated deoxynivalenol (DON).
11 . The method according to claim 10 , characterised in that the vaccine is systemically administered to the swine.
12 . The method according to claim 10 , characterised in that the vaccine is administered intramuscularly or intradermally to the swine.
13 . The method according to claim 10 , characterised in that the vaccine is administered to the swine at an age of 6 weeks or younger.
14 . The method according to claim 10 , characterised in that the vaccine is administered to the swine at an age of 4 weeks or younger, preferably at an age of 1-3 weeks.
15 . A kit-of-parts comprising in combination a first composition comprising in combination a non-replicating immunogen of porcine circo virus type 2 (PCV2), a non-replicating immunogen of Mycoplasma hyopneumoniae , and a second composition comprising a conjugated deoxynivalenol (DON).