METHOD OF TREATMENT OF PAIN THROUGH BUCCAL ADMINISTRATION OF FLUNIXIN
A buccal administration method of flunixin has been developed now to provide an easy to use and effective method of reducing pain in livestock animals (e.g. swine, cattle, sheep, goats, etc.).
1 . A method of treating pain in an animal comprising buccal administration to an animal in need thereof of a composition comprising flunixin or a salt thereof and a pharmaceutically acceptable carrier.
2 . The method of claim 1 , wherein the flunixin is flunixin meglumine.
3 . The method of claim 1 , wherein the pharmaceutically acceptable carrier comprises one or more penetration enhancers, an aprotic primary solvent or mixtures thereof.
4 . The method of claim 3 , wherein the penetration enhancers are menthol, propylene glycol dicaprylate/dicapratecaprate or mixtures thereof.
5 . The method of claim 3 , wherein the aprotic primary solvent is a pyrrolidone solvent.
6 . The method of claim 3 , wherein the aprotic primary solvent is 2-pyrollidone.
7 . The method of claim 1 , wherein the animal is a livestock animal.
8 . The method of claim 7 , wherein the livestock animal is a pig, a goat, a sheep or a bovid.
9 . The method of claim 8 , wherein the animal is a pig.
10 . The method of claim 1 , wherein the pain is a result of castration, tail docking or removal of needle teeth.
11 . The method of claim 1 , wherein the buccal administration is to the inside of the cheek of the animal.
12 . A method of treating pain comprising buccal administration to an animal in need thereof a composition comprising.
a) flunixin meglumine,
b) 2-pyrrolindone,
c) menthol,
d) propylene glycol dicaprylate/dicapratecaprate, and
e) glyceryl monocaprylate.
13 . The method of claim 12 , wherein the animal is a pig.