A METHOD OF TREATING FOOT ROT

1 . A method of treating or preventing foot rot disease in a bovid animal comprising administering to the bovid animal an injectable pharmaceutical composition comprising tildipirosin, a salt or solvate thereof and a pharmaceutically acceptable carrier.

2 . The method of claim 1 , wherein the pharmaceutically acceptable carrier comprises one or more excipients.

3 . The method of claim 1 , wherein the injectable pharmaceutical composition is a solution or a suspension.

4 . The method of claim 3 , wherein the injectable pharmaceutical composition is a solution.

5 . The method of claim 4 , wherein the excipients are one or more solvents.

6 . The method of claim 5 , wherein the solvents are propylene glycol, water or mixtures thereof.

7 . The method of claim 1 , wherein the tildipirosin is the form of the free base.

8 . The method of claim 7 , wherein the pharmaceutical composition further comprises an acid.

9 . The method of claim 8 , wherein the acid is citric acid.

10 . The method of claim 1 , wherein the dose of the tildipirosin is from about 1 mg/kg to about 10 mg/kg of body weight of the animal or from about 3 mg/kg to about 7 mg/kg or preferably about 4 mg/kg.

11 . The method of claim 4 , wherein the concentration of the tildipirosin is from about 10% w/v to about 25% w/v, from about 15% w/v to about 20% w/v, preferably 18% w/v.

12 . The method of claim 1 , wherein each mL of the composition comprises

a) 180 mg of tildipirosin as the free base;

b) 82.5 mg citric acid monohydrate;

c) 400 mg propylene glycol; and

d) water qs.

13 . The method of claim 3 , wherein the injectable pharmaceutical composition is a suspension.

14 . The method of claim 13 , comprising a salt or a solvate of tildipirosin.

15 . The method of claim 1 , wherein the injectable pharmaceutical composition is administered as a single injection.