CONJUGATED T-2 TOXIN TO PROTECT AGAINST MYCOTOXICOSIS
The present invention pertains to the use of conjugated T-2 toxin (T2) in a method to protect an animal against T2 induced mycotoxicosis, in particular to protect against a decrease in average daily weight gain, intestinal damage, skin damage and snout damage, thus one or more of these signs of mycotoxicosis induced by T2 as a result of the ingestion of T2.
1 . A method of protecting an animal against T-2 toxin (T2)-induced mycotoxicosis comprising administering to the animal a conjugated T2.
2 . The method according to claim 1 , wherein the method protects the animal against one or more of the clinical signs of the T2 induced mycotoxicosis, and wherein the clinical signs are chosen from the group consisting of decreased weight gain, intestinal damage, skin damage and snout damage.
3 . The method according to claim 1 , wherein the conjugated T2 is systemically administered to the animal.
4 . The method according to claim 3 , wherein the conjugated T2 is administered intramuscularly, orally and/or intradermally.
5 . The method according to claim 1 , wherein the conjugated T2 is administered to the animal at an age of 6 weeks or younger.
6 . The method according to claim 5 wherein the conjugated T2 is administered to the animal at an age of 4 weeks or younger.
7 . The method according to claim 6 , wherein the conjugated T2 is administered to the animal at an age of 1-3 weeks.
8 . The method according to claim 1 , wherein the conjugated T2 is administered to the animal at least twice.
9 . (canceled)
10 . (canceled)
11 . (canceled)
12 . (canceled)
13 . (canceled)
14 . The method according to claim 1 , characterised in that the animal is a swine or chicken.
15 . A vaccine comprising conjugated T2, an adjuvant and a pharmaceutically acceptable carrier.
16 . The vaccine of claim 15 , wherein the adjuvant is an emulsion of water and oil.
17 . The vaccine of claim 16 , wherein the adjuvant is a water-in-oil emulsion or an oil-in-water emulsion.
18 . The vaccine of claim 15 , wherein the conjugated T2 comprises T2 conjugated to a protein having a molecular mass above 10.000 Da.
19 . The vaccine of claim 15 , wherein the conjugated T2 comprises T2 conjugated to keyhole limpet hemocyanin (KLH) or ovalbumin (OVA).