MEDICAL ARTICLES WITH MICROSTRUCTURED SURFACE HAVING INCREASED MICROORGANISM REMOVAL WHEN CLEANED AND METHODS THEREOF
Structured surfaces are described. In one embodiment, the structured surface comprises a plurality of structures having a complement cumulative slope magnitude distribution (Fcc) such that at least 30, 40, 50, 60, 70, 80 or 90% of structures have a slope greater than 10 degrees; and less than 80% of the structures have a slope greater than 35 degrees. In other embodiments, the structures comprise peaks and valleys defined by a Cartesian coordinate system such that the peaks and valleys have a width and length in the x-y plane and a height in the z-direction and at least a portion of the peaks and/or valleys vary in height in the y direction and/or the x-direction by at least 10% of the average height. Articles and methods are also described.
1 . A medical article comprising:
a base member; and
a microstructured surface disposed on one or more surfaces of the base member,
the microstructured surface comprising an array of peak structures and adjacent valleys,
wherein the valleys have a maximum width ranging from 10 microns to 250 microns and the peak structures have a side wall angle of greater than 10 degrees;
wherein the medical article is a dental retainer, dental split, palatal expander, sleep apnea oral appliance or nociceptive trigeminal inhibition tension suppression system.
2 . The medical article of claim 1 , wherein adjacent peak structures are interconnected proximate the base member in at least one direction.
3 . The medical article of claim 1 , wherein the peak structures comprise two or more facets.
4 . The medical article of claim 3 , wherein the facets form a continuous or semi-continuous surface in the same direction.
5 . The medical article of claim 1 , wherein the microstructured surface comprises a linear array of prisms or an array of cube-corner elements.
6 . The medical article of claim 3 , wherein peak structures have an apex that is sharp, rounded, or truncated.
7 . The medical article of claim 1 wherein the peak structures have an apex angle ranging from 20 to 120 degrees.
8 . The medical article of claim 7 , wherein the peak structures and valleys are free of flat surface area.
9 . The medical article of claim 8 , wherein the peak structures and/or valleys are truncated such that the microstructured surface comprises less than 50, 40, 30, 20 or 10% of flat surface area.
10 . The medical article of claim 1 , wherein the base member and peak structures comprise the same or different materials.
11 . The medical article of claim 1 , wherein the base member and peak structures comprises an organic polymeric material.
12 . The medical article of claim 1 , wherein the microstructured surface and base member are transparent, light-transmissive, or opaque.
13 . The medical article of claim 1 , further comprising an adhesive or primer disposed between the base member and the microstructured surface.
14 . The medical article of claim 1 , wherein the microstructured surface is disposed on a first major external surface, a second major internal surface, or a combination thereof.
15 . The medical article of claim 1 , wherein the microstructured surface is provided on the base member by coating, injection molding, embossing, laser etching, extrusion, or casting and curing a polymerizable resin.
16 - 21 . (canceled)
23 . The medical article of claim 1 , wherein the microstructured surface provides a log 10 reduction of bacteria of at least 2, 3, 4, 5, or 6 after the cleaning.
24 . The medical article of claim 1 wherein the bacteria is a virus or Phi6 Bacteriophage.