TREATMENT OF SLEEP APNEA WITH CBD
Provided are methods of treating sleep disorders in patients by transdermally administering an effective amount of cannabidiol (CBD) to a subject in need thereof.
1 . A method of treating sleep disturbances in a human subject, the method comprising:
administering an effective amount of cannabidiol (CBD) to the human in need thereof to treat the sleep disturbances.
2 . The method of claim 1 , wherein the sleep disturbances are caused by episodes of sleep apnea.
3 . The method according to claim 1 or 2 , wherein the CBD is administered transdermally.
4 . The method according to any of the preceding claims , wherein the effective amount of CBD ranges from about 250 mg to about 1000 mg total daily.
5 . The method of any of the preceding claims , wherein the effective dose of CBD is in the range of 10-25 mg/kg per dose.
6 . The method according to any of the preceding claims , wherein the CBD is administered in a single daily dose.
7 . The method according to any of the preceding claims , wherein the CBD is administered in two daily doses.
8 . The method according to any of the preceding claims , wherein the treatment includes an improvement in sleep-related impairment.
9 . The method of claim 8 , wherein an improvement in sleep-related impairment includes improvements in sleep quality, sleep onset, total sleep, initiating and maintain sleep, sleep wake transition, or disorders of arousal and nightmares.
10 . The method according to any of the preceding claims , wherein the CBD is a pure CBD.
11 . The method according to any of the preceding claims , wherein the CBD is a synthetic CBD.
12 . The method according to any of claims 1-9 , wherein the CBD is botanically derived.
13 . The method according to any of the preceding claims , wherein the cannabidiol is (−)-cannabidiol.
14 . The method according to any of the preceding claims , wherein the CBD is formulated as a gel.
15 . The method of claim 14 , wherein the CBD is formulated as a permeation-enhanced gel.
16 . The method of any one of the preceding claims , wherein the subject suffers from obstructive sleep apnea.
17 . The method of claim 16 , wherein the obstructive sleep apnea is associated with obesity or an overweight condition of the subject.
18 . The method according to any of the preceding claims , wherein the subject is an adult.
19 . The method according to any of claims 1-17 , wherein the subject is between 3 and 18 years old.
20 . The method according to any of the preceding claims , wherein the subject has ASD.
21 . The method according to any of the preceding claims , wherein the subject has DEE-ASD.
22 . The method according to any of the preceding claims , wherein the subject has a BMI of greater than 25.
23 . The method according to any of the preceding claims , wherein, upon beginning administering the effective amount of CBD, circadian rhythm is maintained or improved.