Patent Application
Utility
PCT National Stage
App. No. 18/263,155
· Confirmation No. 3656
iRNA COMPOSITIONS AND METHODS FOR SILENCING AMYLOID PRECURSOR PROTEIN (APP)
Applicant:
Alnylam Pharmaceuticals, Inc.
Response to Non-Final Office Action Entered and Forwarded to Examiner
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| 2026-07-31 | A... |
Amendment/Request for Reconsideration-After Non-Final Rejection | — | View | |
| 2026-07-31 | A... |
Amendment/Request for Reconsideration-After Non-Final Rejection | 1 | View | |
| 2026-07-31 | SPEC |
Specification | 7 | View | |
| 2026-07-31 | CLM |
Claims | 9 | View | |
| 2026-07-31 | REM |
Applicant Arguments/Remarks Made in an Amendment | 8 | View | |
| 2026-07-31 | IDS |
Information Disclosure Statement (IDS) Form (SB08) | 5 | View | |
| 2026-07-31 | N417 |
Electronic Filing System Acknowledgment Receipt | 3 | View | |
| 2026-07-31 | N417.PYMT |
Electronic Fee Payment | 2 | View | |
| 2026-07-31 | WFEE |
Fee Worksheet (SB06) | 1 | View | |
| 2026-05-05 | CTNF |
Non-Final Rejection | 20 | View | |
| 2026-05-05 | 892 |
List of references cited by examiner | 1 | View | |
| 2026-05-05 | SRFW |
Search information including classification, databases and other search related notes | 2 | View | |
| 2026-05-05 | 1449 |
List of References cited by applicant and considered by examiner | 5 | View | |
| 2026-05-05 | BIB |
Bibliographic Data Sheet | 1 | View | |
| 2026-05-05 | SRNT |
Examiner's search strategy and results | 67 | View | |
| 2026-05-05 | SRNT |
Examiner's search strategy and results | 36 | View | |
| 2026-05-05 | 1449 |
List of References cited by applicant and considered by examiner | 4 | View | |
| 2026-05-05 | SRNT |
Examiner's search strategy and results | 1 | View | |
| 2026-05-05 | 1449 |
List of References cited by applicant and considered by examiner | 4 | View | |
| 2026-05-05 | SRNT |
Examiner's search strategy and results | 5 | View | |
| 2026-05-05 | SRNT |
Examiner's search strategy and results | 28 | View | |
| 2026-05-05 | 1449 |
List of References cited by applicant and considered by examiner | 27 | View | |
| 2026-05-05 | SRNT |
Examiner's search strategy and results | 1 | View | |
| 2026-05-05 | FOR |
Foreign Reference | 233 | View | |
| 2026-03-26 | ELC. |
Response to Election / Restriction Filed | — | View | |
| 2026-03-26 | ELC. |
Response to Election / Restriction Filed | 1 | View | |
| 2026-03-26 | CLM |
Claims | 9 | View | |
| 2026-03-26 | REM |
Applicant Arguments/Remarks Made in an Amendment | 3 | View | |
| 2026-03-26 | IDS |
Information Disclosure Statement (IDS) Form (SB08) | 5 | View | |
| 2026-03-26 | FOR |
Foreign Reference | 271 | View | |
| 2026-03-26 | REF.OTHER |
Other reference-Patent/Application/Search Documents | 17 | View | |
| 2026-03-26 | FOR |
Foreign Reference | 134 | View | |
| 2026-03-26 | FOR |
Foreign Reference | 320 | View | |
| 2026-03-26 | REF.OTHER |
Other reference-Patent/Application/Search Documents | 15 | View | |
| 2026-03-26 | N417 |
Electronic Filing System Acknowledgment Receipt | 3 | View | |
| 2026-03-26 | WFEE |
Fee Worksheet (SB06) | 1 | View | |
| 2026-02-03 | CTRS |
Requirement for Restriction/Election | 11 | View | |
| 2026-02-03 | 892 |
List of references cited by examiner | 1 | View | |
| 2024-04-11 | NTC.PUB |
Notice of Publication | 1 | View | |
| 2024-03-07 | N570 |
Communication - Re: Power of Attorney (PTOL-308) | 1 | View | |
| 2024-03-06 | M903 |
Notice of Designated Office (DO) / Elected Office (EO) Acceptance Mailed | 2 | View | |
| 2024-03-06 | APP.FILE.REC |
Filing Receipt | 4 | View | |
| 2024-03-06 | WCLM |
Claims Worksheet (PTO-2022) | 1 | View | |
| 2024-03-06 | WFEE |
Fee Worksheet (SB06) | 1 | View | |
| 2024-02-09 | N417 |
Electronic Filing System Acknowledgment Receipt | 12 | View | |
| 2024-02-09 | PEFR |
Applicant Response to Pre-Exam Formalities Notice | — | View | |
| 2024-02-09 | FOR |
Foreign Reference | 44 | View | |
| 2024-02-09 | FOR |
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| 2024-02-09 | FOR |
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| 2024-02-09 | FOR |
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| 2024-02-09 | FOR |
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| 2024-02-09 | FOR |
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| 2024-02-09 | FOR |
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| 2024-02-09 | FOR |
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| 2024-02-09 | FOR |
Foreign Reference | 406 | View | |
| 2024-02-09 | FOR |
Foreign Reference | 174 | View | |
| 2024-02-09 | N417 |
Electronic Filing System Acknowledgment Receipt | 13 | View | |
| 2024-02-09 | PEFR |
Applicant Response to Pre-Exam Formalities Notice | 1 | View | |
| 2024-02-09 | CLM |
Claims | 10 | View | |
| 2024-02-09 | REM |
Applicant Arguments/Remarks Made in an Amendment | 2 | View | |
| 2024-02-09 | FOR |
Foreign Reference | 132 | View | |
| 2024-02-09 | FOR |
Foreign Reference | 58 | View | |
| 2024-02-09 | FOR |
Foreign Reference | 103 | View | |
| 2024-02-09 | TRAN.LET |
Transmittal Letter | 1 | View | |
| 2024-02-09 | FOR |
Foreign Reference | 98 | View | |
| 2024-02-09 | FOR |
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| 2024-02-09 | FOR |
Foreign Reference | 120 | View | |
| 2024-02-09 | FOR |
Foreign Reference | 33 | View | |
| 2024-02-09 | IDS |
Information Disclosure Statement (IDS) Form (SB08) | 27 | View | |
| 2024-02-09 | FOR |
Foreign Reference | 68 | View | |
| 2024-02-09 | FOR |
Foreign Reference | 77 | View | |
| 2024-02-09 | FOR |
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| 2024-02-09 | FOR |
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| 2024-02-09 | FOR |
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| 2024-02-09 | FOR |
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| 2024-02-09 | FOR |
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| 2024-02-09 | FOR |
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| 2024-02-09 | FOR |
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| 2024-02-09 | FOR |
Foreign Reference | 108 | View | |
| 2024-02-09 | FOR |
Foreign Reference | 190 | View | |
| 2023-12-20 | N417 |
Electronic Filing System Acknowledgment Receipt | 2 | View | |
| 2023-12-20 | PA.. |
Power of Attorney | 1 | View | |
| 2023-12-20 | R3.73 |
Assignee showing of ownership per 37 CFR 3.73 | 2 | View | |
| 2023-12-11 | APP.FILE.REC |
Filing Receipt | 4 | View | |
| 2023-12-11 | 371.FEE.M923 |
371 (National Stage) Supplemental Fees Missing - Form M923 | 2 | View | |
| 2023-12-11 | WCLM |
Claims Worksheet (PTO-2022) | 1 | View | |
| 2023-12-11 | WFEE |
Fee Worksheet (SB06) | 1 | View | |
| 2023-12-11 | WELCOME.LET |
Welcome Letter from USPTO Director and Deputy Director | 1 | View | |
| 2023-11-10 | N417 |
Electronic Filing System Acknowledgment Receipt | 2 | View | |
| 2023-11-10 | REF.OTHER |
Other reference-Patent/Application/Search Documents | 7 | View | |
| 2023-11-10 | IDS |
Information Disclosure Statement (IDS) Form (SB08) | 4 | View | |
| 2023-08-03 | CRFE |
Sequence Listing in Computer Readable Format, No errors found | — | View | |
| 2023-08-03 | CRFE |
Sequence Listing in Computer Readable Format, No errors found | 15 | View | |
| 2023-07-27 | A.PE |
Preliminary Amendment | — | View | |
| 2023-07-27 | ADS |
Application Data Sheet | 9 | View | |
| 2023-07-27 | IDS |
Information Disclosure Statement (IDS) Form (SB08) | 4 | View | |
| 2023-07-27 | OATH |
Oath or Declaration filed | 2 | View | |
| 2023-07-27 | FOR |
Foreign Reference | 171 | View | |
| 2023-07-27 | REF.OTHER |
Other reference-Patent/Application/Search Documents | 12 | View | |
| 2023-07-27 | N417 |
Electronic Filing System Acknowledgment Receipt | 4 | View | |
| 2023-07-27 | TRNA |
Transmittal of New Application | 4 | View | |
| 2023-07-27 | A.PE |
Preliminary Amendment | 1 | View | |
| 2023-07-27 | SPEC |
Specification | 1 | View | |
| 2023-07-27 | CLM |
Claims | 11 | View | |
| 2023-07-27 | REM |
Applicant Arguments/Remarks Made in an Amendment | 2 | View | |
| 2023-07-27 | N417.PYMT |
Electronic Fee Payment | 2 | View | |
| 2023-07-27 | 371P |
Documents submitted with 371 (National Stage) Applications | 1 | View | |
| 2023-07-27 | 371P |
Documents submitted with 371 (National Stage) Applications | 2 | View | |
| 2023-07-27 | FRPR |
Certified Copy of Foreign Priority Application | 216 | View | |
| 2023-07-27 | P.N.101.CONV |
PCT/RO/101 - Request form for new International Application - Conventional | 4 | View | |
| 2023-07-27 | FRPR |
Certified Copy of Foreign Priority Application | 207 | View | |
| 2023-07-27 | ABST |
Abstract | 2 | View | |
| 2023-07-27 | CLM |
Claims | 12 | View | |
| 2023-07-27 | DRW |
Drawings-only black and white line drawings | 2 | View | |
| 2023-07-27 | SPEC |
Specification | 189 | View | |
| 2023-07-27 | SEQ.TXT |
Sequence Listing (Text File) | 1 | View |
Inventors
Jeffrey Zuber
Cambridge, MA
Adam Castoreno
Cambridge, MA
Attorneys & Agents of Record
Classification
USPC
514/44A
C12N15/113
A61P25/28
A61K31/713
A61K48/0058
C12N2310/11
C12N2310/14
C12N2310/315
C12N2310/343
C12N2310/3515
C12N2320/11
C12Q1/6883
C12Q2600/136
C12Q2600/156
C12Q2600/178
C12N2310/322
C12N2310/3533
C12N2310/321
C12N2310/3521
Prosecution
- Examiner
- TATGE, LEXUS MARC
- Art Unit
- 1637
- Customer No.
- 168188
- Docket No.
- A108868 1760US.PCT 485.3
- Confirmation No.
- 3656
Publication
- Pub. No.
- US20240117349A1
- Pub. Date
- 2024-04-11
Parent
PCT
is a National Stage Entry of
→
PCT/US2022/014309
Filed 2022-01-28
· Response to Non-Final Office Action Entered and Forwarded to Examiner
Parent
Claims priority from a provisional application
→
App. 63/143,608
Filed 2021-01-29
· Provisional Application Expired
Parent
Claims priority from a provisional application
→
App. 63/173,997
Filed 2021-04-12
· Provisional Application Expired
SECURITY INTEREST
Recorded 2025-10-01
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded 2023-12-18
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Quick Facts
- App. No.
- 18/263,155
- Filed
- 2023-07-27
- Pub. No.
- US20240117349A1
- Examiner
- TATGE, LEXUS MARC
- Art Unit
- 1637
External Links