Systems and methods for long term transdermal administration

1. A transdermal patch, comprising:

(a) an outermost backing layer;

(b) an interfacing adhesive layer;

(c) a segmented intermediate layer comprised of:

(i) an occlusive backing layer;

(ii) an adhesive active agent layer comprising an active agent and sodium bicarbonate;

(iii) a microporous membrane; and

(iv) a contact adhesive layer;

wherein the segmented intermediate layer is comprised of a plurality of segments that are at least partially separated, and

(d) a removable release liner in contact with the contact adhesive layer.

2. The transdermal patch of claim 1 , wherein the outermost backing layer is comprised of an elastic polymer film, a polymer fabric, a multi-directional elastic woven fabric, a multi-directional elastic nonwoven fabric, a stretchable polymer film, a stretchable woven fabric, or a stretchable nonwoven fabric.

3. The transdermal patch of claim 1 , wherein the outermost backing layer is comprised of an elastic material.

4. The transdermal patch of claim 1 , wherein the outermost backing layer is comprised of one or more polymers selected from polyesters, polyethylenes, polypropylenes, polyvinylchloride, polyethylene vinyl acetate or copolymers thereof, and polyurethanes.

5. The transdermal patch of claim 1 , wherein the interfacing adhesive layer is comprised of one or more polymers selected from selected from acrylates, acrylate copolymers, polyisobutylene, silicone, polystyrene butyl rubber, polyethylene vinyl acetate and copolymers thereof, and plasticized polymers.

6. The transdermal patch of claim 1 , wherein the occlusive backing layer is a laminate comprising a polyester layer.

7. The transdermal patch of claim 1 , wherein the occlusive backing layer is comprised of a material fabricated from one or more polymers selected from polyesters, polyethylenes, polypropylenes, polystyrenes, polyvinylchloride, and a polyethylene terephthalate/ethylene vinyl acetate laminate.

8. The transdermal patch of claim 1 , wherein the microporous membrane is a polypropylene microporous membrane.

9. The transdermal patch of claim 1 , where each segment of the composite layer has a size of about 2-40 cm2.

10. The transdermal patch of claim 1 , wherein at least the outermost backing layer and the release liner are sized to extend about 0.5-1.0 cm beyond the perimeter of the composite layer.

11. The transdermal patch of claim 1 , wherein the release liner is comprised of a material selected from a silicone coated material, a fluorocarbon coated material, and a fluorosilicone coated material.

12. The transdermal patch of claim 1 , wherein at least the outermost backing layer and the interfacing adhesive layers are laminated.

13. The transdermal patch of claim 1 , wherein the occlusive backing layer and the adhesive active agent layer are laminated.

14. The transdermal patch of claim 1 , wherein the adhesive active agent layer, the contact adhesive layer, or both are comprised of an acrylic adhesive.

15. A method for transdermally administering an active agent, comprising:

(i) removing a release liner from the transdermal patch of claim 1 ; and

(ii) adhering the transdermal patch to the skin of a patient for a period up to about 10 days to deliver the active agent to said patient.

16. The transdermal patch of claim 1 , wherein the active agent is donepezil or a salt thereof.

17. The transdermal patch of claim 1 , wherein the active agent is donepezil hydrochloride.