Adhesive containing microparticles
Methods for forming and incorporating microparticles containing one or more active agents into adhesives are described. The methods involve spray drying a liquid of the one or more active agents and obtaining the active agent in a particulate form. The dry powder is then blended or otherwise incorporated with the adhesive of interest. Also described are various medical products utilizing the adhesive and one or more active agents in microparticle form, and related methods of use.
1. An adhesive composition comprising:
an adhesive;
microparticles dispersed in the adhesive, the microparticles including a matrix material and at least one active agent;
wherein at least one active agent is hydrophilic;
wherein the matrix material is at least one selected from the group consisting of fillers, preservatives, and sorbents; and
wherein the adhesive is selected from the group consisting of acrylic adhesives, rubber adhesives, silicone adhesives, polyurethane adhesives, and combinations thereof.
2. The adhesive of claim 1 wherein the adhesive is one of a solvent based adhesive and a hot melt adhesive.
3. The adhesive of claim 1 wherein the microparticles have an average span of from about 5 microns to about 50 microns.
4. The adhesive of claim 1 wherein the active agent is selected from the group consisting of pain reducing agents, analgesics and anti-inflammatory agents, corticosteriods, antibiotics, antimicrobial agents, antifungal agents, debriding agents, antihistamines, antiepileptics, coronary vasodilators, dermatologicals, ancillary drugs, and combinations thereof.
5. The adhesive of claim 4 wherein the active agent is a pain reducing agent selected from the group consisting of pain reducing agents such as benzocaine, procaine hydrochloride, tetracaine, tetracaine hydrochloride, dibucaine, lidocaine, lidocaine hydrochloride, bupivicaine, dyclonin, etidocaine, mepivicaine, butamen picrate, dimethisoquin hydrochloride, cyclomethylcaine sulfate, and combinations thereof.
6. The adhesive of claim 4 wherein the active agent is an analgesic and anti-inflammatory agent selected from the group consisting of buprenorphin, butophanol tartrate, acetaminophen, fentanyl, mefenamic acid, flutenamic acid, diclofenac, oxyphenbutazone, phenybutazone, ibuprofen, flurbiprofen, naproxen, menthol, methyl salicylate, phenol, salicylic acid, benzyl alcohol, camphor, camphorated metacresol, juniper tar, resorcinol, allyl isothiocyanate, capsaicin, and combinations thereof.
7. The adhesive of claim 4 wherein the active agent is a corticosteroid selected from the group consisting of alclometasone dipropionate, amcinocide, hydrocortisone, betamethasone dipropionate, betamethasone valerate, desoximetasone, clobetasol propionate, flurandrenolide, halcinonide, halobetasol, estradiol, testosterone, progesterone, fluticasone, clobetasol, dexamethasone, dexonide, fluocinolone acetonide, flucinonide, medroxyprogesterone, mometasone furoate, triamcinolone, and combination thereof.
8. The adhesive of claim 4 wherein the active agent is an antibiotic selected from the group consisting of bacitracin, bacitracin zinc, chlortetracycline hydrochloride, chlorhexadine gluconate, clindamycin, cliquinol, neomycin sulfate, polymyxin B sulfate, erythromycin, gentamicin, sulfathiazole, sulfacetamide, sulfabenzamide, oxytetracycline hydrochloride, tetracycline, and combinations thereof.
9. The adhesive of claim 4 wherein the active agent is an antimicrobial agent selected from the group consisting of benzalkonium chloride, chlorhexidine gluconate, hexachlorophene, mafenide acetate, nitrofurazone, nystatin, acetosulfamine, clortrimazole, povidone-iodine, and combinations thereof.
10. The adhesive of claim 4 wherein the active agent is an antifungal agent selected from the group consisting of amphotericin B, butoconazole, cetylpyridinium chloride, chlorxylenol, cyclopirox olamine, clioquinol, clotrimazole, sulconazole nitrate, nystatin, oxyconazole, econazole nitrate, ketoconazole, miconazole nitrate, naftifine hydrochloride, pentamycin, pyrrolinitrin, terbinafine, triacetin, and combinations thereof.
11. The adhesive of claim 4 wherein the active agent is a debriding agent selected from the group consisting of deoxyribonuclease, collagenolytic, debridement, fibrinolytic or proteolytic enzymes, papain, papain-urea, and combinations thereof.
12. The adhesive of claim 4 wherein the active agent is an antihistamine selected from the group consisting of chlorcyclizine hydrochloride, diphenylhydramine hydrochloride, tripelennamine hydrochloride, and combinations thereof.
13. The adhesive of claim 4 wherein the active agent is an antiepileptic selected from the group consisting of nitrazepam, meprobamate, clonazepam, and combinations thereof.
14. The adhesive of claim 4 wherein the active agent is a coronary vasodilator selected from the group consisting of nitroglycerine, dipyridamole, erythritol, tetranitrate, pentaerythritol tetranitrate, propatyinitrate, and combinations thereof.
15. The adhesive of claim 4 wherein the active agent is a dermatological agent selected from the group consisting of dermatologicals such as retinal, retinol, retinoic acid and their derivatives, hydroxyacids, alphaketoacids, and combinations thereof.
16. The adhesive of claim 4 wherein the active agent is an ancillary drug selected from the group consisting of benzoyl peroxide, podofilox, masoprocol, nicotine, scopolamine, nitroglycerine, fluorouracil, hydrocolloids, hydroquinone, monobenzone, tretinoin and acyclovir, Vitamin C, Vitamin E, and combinations thereof.
17. The adhesive of claim 1 wherein the filler is selected from the group consisting of plant cellulose, dibasic calcium phosphate, vegetable fats and oils, sugar fillers, calcium carbonate, magnesium stearate, and combinations thereof.
18. The adhesive of claim 1 wherein the preservative is selected from the group consisting of antioxidants, amino acid preservatives, citric acid, sodium citrate, synthetic preservatives, and combinations thereof.
19. The adhesive composition of claim 1 further comprising a binder.