Cardiac pulsed field ablation
A method for ablating tissue by applying at least one pulse train of pulsed-field energy. The method includes delivering a pulse train of energy having a predetermined frequency to cardiac tissue, the pulse train including at least 60 pulses, an inter-phase delay between Oμs and 5 μs, an inter-pulse delay of at least 5 μs, and a pulse width of 5 μs.
1. A medical device comprising:
a generator in electrical communication with a plurality of electrodes, wherein:
the generator is configured to deliver a pulse train of energy having a predetermined frequency and including a plurality of pulses, each pulse having a pulse width of between 1 μs and 5 μs;
the plurality of pulses includes a sequence of alternating positive pulses and negative pulses with an inter-phase delay after each positive pulse and before a subsequent negative pulse and with an inter-pulse delay after each negative pulse and before a subsequent positive pulse; and
the inter-phase delay is less than the inter-pulse delay.
2. The medical device of claim 1 , wherein the pulse width of each positive pulse is symmetrical to the pulse width of each negative pulse.
3. The medical device of claim 1 , wherein the generator includes an electrical current generator and is configured to control a voltage of the plurality of pulses.
4. The medical device of claim 3 , wherein the voltage of the plurality of pulses is between 300 V and 4,000 V.
5. The medical device of claim 1 , wherein the inter-pulse delay is at least 5 μs.
6. The medical device of claim 1 , wherein the inter-phase delay is between 0 μs and 4 μs.
7. The medical device of claim 1 , wherein the pulse train of energy include biphasic pulses.
8. The medical device of claim 1 , wherein the inter-phase delay, the inter-pulse delay, and the pulse width are constant over the duration of the pulse train of energy.
9. The medical device of claim 1 , wherein the pulse train of energy includes at least 20 pulses.
10. The medical device of claim 1 , wherein the generator is configured to deliver a plurality of pulse trains of energy at a treatment site.
11. The medical device of claim 1 , wherein the pulse train of energy is configured to produce efficacious lesions in cardiac tissue.
12. A method of ablating tissue comprising:
delivering a pulse train of energy having a predetermined frequency to tissue, the pulse train including a plurality of pulses, each pulse having a pulse width of between 1 μs and 5 μs,
the plurality of pulses including a sequence of alternating positive pulses and negative pulses with an inter-phase delay after each positive pulse and before a subsequent negative pulse and with an inter-pulse delay after each negative pulse and before a subsequent positive pulse,
the inter-phase delay being less than the inter-pulse delay.
13. The method of claim 12 , wherein the pulse width of each positive pulse is symmetrical to the pulse width of each negative pulse.
14. The method of claim 12 , wherein the plurality of pulse have a plurality of voltage amplitudes.
15. The method of claim 12 , wherein the voltage of the plurality of pulses is between 300 V and 4,000 V.
16. The method of claim 12 , wherein the inter-pulse delay is at least 5 μs.
17. The method of claim 12 , wherein the inter-phase delay is between 0 μs and 4 μs.
18. The method of claim 12 , wherein the pulse train of energy include biphasic pulses.
19. The method of claim 12 , wherein the inter-phase delay, the inter-pulse delay, and the pulse width are constant over the duration of the pulse train of energy.
20. The method of claim 12 , wherein the pulse train of energy includes at least 60 pulses.