TRANSDERMAL ADHESIVE COMPOSITION COMPRISING A POORLY SOLUBLE THERAPEUTIC AGENT
Methods, compositions, and devices for transdermally administering an active agent such as donepezil are provided.
1 . A composition for preparing a patch for transdermal delivery of donepezil, comprising:
an adhesive matrix comprising
(a) about 5-50 wt % donepezil free base;
(b) about 5-50 wt % of at least one adhesive polymer that is a mixture of polyisobutylene and polybutene polymers;
(c) about 5-40 wt % of at least one solubility enhancer selected from dimethyl succinate and diethyl succinate; and
(d) about 1-20 wt % of at least one lipophilic permeation enhancer selected from a fatty acid, and α-hydroxy acid, a β-hydroxy acid, and a keto carboxylic acid.
2 .- 5 . (canceled)
6 . The composition of claim 1 , wherein the at least one solubility enhancer is present in an amount of about 10-40 wt %.
7 . (canceled)
8 . The composition of claim 1 , further comprising at least a second permeation enhancer.
9 . The composition of claim 8 , wherein the second permeation enhancer is selected from methyl laurate, propylene glycol monolaurate, glycerol monolaurate, glycerol monooleate, lauryl lactate, laurydone, and myristyl lactate.
10 .- 19 . (canceled)
20 . A composition for preparing a patch for transdermal delivery of donepezil, comprising:
an adhesive matrix comprising:
(a) about 5-20 wt % donepezil in free base form;
(b) about 2-6 wt % lauryl lactate or lauryl pyrrolidone carboxylate;
(c) about 5-20 wt % dimethyl succinate;
(d) about 0-15% dimethyl sulfoxide;
(e) about 1-10 wt % levulinic acid or lactic acid;
(f) about 3-20 wt % fumed silica and/or cross-linked polyvinyl pyrrolidone;
(g) about 35 to 80 wt % of an adhesive consisting of a mixture of polyisobutylene and polybutene or a hydrogenated polybutene, wherein said mixture of polyisobutylene and polybutene is the sole adhesive agent present in the adhesive matrix, and wherein said mixture consists of between 25-45 wt % polybutene and between 55-75 wt % polyisobutylene.
21 . A composition for preparing a patch for transdermal delivery of donepezil, comprising:
an adhesive matrix comprising:
(a) about 5-20 wt % donepezil in free base form;
(b) about 2-6 wt % lauryl lactate;
(c) about 5-15 wt % of a vinyl acetate and N-vinyl pyrrolidone co-polymer;
(d) about 40-60 wt % of an acrylic adhesive; and
(e) about 5-20 wt % of an adhesive comprising polyisobutylene and polybutene.
22 . A transdermal delivery patch comprising: a composition according to claim 21 .
23 .- 51 . (canceled)
52 . A method for treating Alzheimer's disease, comprising: providing a transdermal patch comprising a composition according to claim 1 .