Granted Patent
B1
US 12,508,256 · App. 18/344,081 · Granted Dec 30, 2025
Pharmaceutical compositions and methods of using the same
Assignee:
NODEN PHARMA DESIGNATED ACTIVITY COMPANY
A61K31/46A61B1/233A61B1/267A61K9/0014A61K9/0019A61K9/0043A61K9/08A61K9/7007A61K31/573A61K45/06A61K47/12
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Abstract
Novel pharmaceutical compositions including cocaine hydrochloride and methods of treating patients using those pharmaceutical compositions are described.
Claims (25)
1 . A pharmaceutical composition for reducing sensation in a body region of a patient and comprising:
about 3.6 to about 4.4 weight percent cocaine hydrochloride;
greater than 0 to less than 5 weight percent sodium citrate; and
greater than 0 to less than 5 weight percent benzoic acid;
wherein a pH of the pharmaceutical composition is in a range of 2.0 to 4.0.
2 . The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition comprises about 4 weight percent cocaine hydrochloride.
3 . The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition comprises greater than 0 to less than 3 weight percent sodium citrate.
4 . The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition comprises greater than 0 to about 2 weight percent benzoic acid.
5 . The pharmaceutical composition of claim 1 , wherein the pH of the pharmaceutical composition is in a range of 2.5 to 4.0.
6 . The pharmaceutical composition of claim 1 , wherein the pH of the pharmaceutical composition is in a range of greater than 2.5 to 4.0.
7 . The pharmaceutical composition of claim 1 , wherein the pH of the pharmaceutical composition is in a range of 3.0 to 4.0.
8 . A pharmaceutical composition for reducing sensation in a body region of a patient and comprising:
about 4 weight percent cocaine hydrochloride;
greater than 0 to less than 5 weight percent sodium citrate; and
greater than 0 to less than 5 weight percent benzoic acid;
wherein a pH of the pharmaceutical composition is in a range of 2.5 to 4.0.
9 . The pharmaceutical composition of claim 8 , wherein the pharmaceutical composition comprises greater than 0 to less than 3 weight percent sodium citrate.
10 . The pharmaceutical composition of claim 8 , wherein the pharmaceutical composition comprises greater than 0 to about 2 weight percent benzoic acid.
11 . The pharmaceutical composition of claim 8 , wherein the pH of the pharmaceutical composition is in a range of 3.0 to 4.0.
12 . A pharmaceutical composition for reducing sensation in a body region of a patient and comprising:
about 3.6 to about 4.4 weight percent cocaine hydrochloride;
greater than 0 to 3 weight percent sodium citrate; and
greater than 0 to 2 weight percent benzoic acid;
wherein a pH of the pharmaceutical composition is in a range of 2.5 to 4.0.
13 . The pharmaceutical composition of claim 12 , wherein the pH of the pharmaceutical composition is in a range of 3.0 to 4.0.
Assignments (4)
SECURITY INTEREST
Recorded Apr 27, 2026
From: LXO IRELAND DESIGNATED ACTIVITY COMPANY
To: KROLL TRUSTEE SERVICES LIMITED, AS SECURITY AGENT
Reel/Frame 074483/0163 →
CHANGE OF NAME
Recorded Dec 10, 2025
From: NODEN PHARMA DESIGNATED ACTIVITY COMPANY
To: LXO IRELAND DESIGNATED ACTIVITY COMPANY
Reel/Frame 073940/0952 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 18, 2023
From: MOSHAL, JEFFREY M.; LIBMAN, MICHAEL
To: GENUS LIFESCIENCES INC.
Reel/Frame 064632/0120 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 18, 2023
From: GENUS LIFESCIENCES INC.
To: NODEN PHARMA DESIGNATED ACTIVITY COMPANY
Reel/Frame 064632/0171 →
Continuity (6)
Continuation
17323361
· May 18, 2021
Continuation
15935776
· Mar 26, 2018
Continuation
15849575
· Dec 20, 2017
Continuation
15470133
· Mar 27, 2017
Continuation
15427011
· Feb 7, 2017
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